WordNet

any of various compounds composed of fatty acids and phosphoric acid and a nitrogenous base; an important constituent of membranes
an optically inactive alcohol that is a component of the vitamin B complex

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Metabolic maturation of the human brain from birth through adolescence: insights from in vivo magnetic resonance spectroscopy.

Blüml S, Wisnowski JL, Nelson MD Jr, Paquette L, Gilles FH, Kinney HC, Panigrahy A.SourceDepartment of Radiology.
Cerebral cortex (New York, N.Y. : 1991).Cereb Cortex.2013 Dec;23(12):2944-55. doi: 10.1093/cercor/bhs283. Epub 2012 Sep 5.
Between birth and late adolescence, the human brain undergoes exponential maturational changes. Using in vivo magnetic resonance spectroscopy, we determined the developmental profile for 6 metabolites in 5 distinct brain regions based on spectra from 309 children from 0 to 18 years of age. The conce
PMID 22952278

Einbond LS, Mighty J, Redenti S, Wu HA.SourceColumbia University College of Physicians and Surgeons, New York, NY 10032, USA; Lehman College, CUNY, Bronx, NY 10468, USA; The New York Botanical Garden, New York, NY 10458, USA. Electronic address: lseinbond@gmail.com.
Fitoterapia.Fitoterapia.2013 Dec;91:28-38. doi: 10.1016/j.fitote.2013.07.025. Epub 2013 Aug 9.
BACKGROUND: The triterpene glycoside actein from the herb black cohosh preferentially inhibits the growth of breast cancer cells and activates the ER stress response. The ER IP3 receptor and Na,K-ATPase form a signaling microdomain. Since actein is lipophilic, its action may be limited by bioavailab
PMID 23939423

PAH1-encoded Phosphatidate Phosphatase Plays a Role in the Growth Phase- and Inositol-mediated Regulation of Lipid Synthesis in Saccharomyces cerevisiae.

Pascual F, Soto-Cardalda A, Carman GM.SourceRutgers University, United States.
The Journal of biological chemistry.J Biol Chem.2013 Nov 6. [Epub ahead of print]
In the yeast Saccharomyces cerevisiae, the synthesis of phospholipids in the exponential phase of growth occurs at the expense of the storage lipid triacylglycerol. As exponential phase cells progress into the stationary phase, the synthesis of triacylglycerol occurs at the expense of phospholipids.
PMID 24196957

Inositol Depletion Restores Vesicle Transport in Yeast Phospholipid Flippase Mutants

Yamagami Kanako,Yamamoto Takaharu,Sakai Shota,Mioka Tetsuo,Sano Takamitsu,Igarashi Yasuyuki,Tanaka Kazuma
Plos one 10(3), e0120108, 2015-03-17
… In eukaryotic cells, type 4 P-type ATPases function as phospholipid flippases, which translocate phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of the lipid bilayer. … Consistent with a previous report that Art5p downregulates the inositol transporter Itr1p by endocytosis, we found that flippase mutations were also suppressed by the disruption of ITR1, as well as by depletion of inositol from the culture medium. …
NAID 120005606034

Studies of inositol 1-phosphate analogues as inhibitors of the phosphatidylinositol phosphate synthase in mycobacteria

SHIP1 DELETION ENHANCES ROS PRODUCTION AND DECREASES SURVIVAL OF THE S. AUREUS INFECTED MICE

Chida Shinsuke,Itoh Reietsu,Kofuji Satoshi [他],Eguchi Satoshi,Takasuga Shunsuke,Sasaki Junko,Sasaki Takehiko
秋田医学 39(3-4), 95-101, 2013-03
… In this study, we investigated a role for SH2 domain-containing inositol- 5-phosphatase 1 (SHIP1), a PtdIns(3,4,5)P3 phosphatase, in ROS production by neutrophils using ship1−/− mice. …
NAID 110009575396