p-selectin glycoprotein ligand-1

同

PSGL-1

同

PSGL-1

WordNet

1. send a message from one computer to another to check whether it is reachable and active; "ping your machine in the office"
2. a sharp high-pitched resonant sound (as of a sonar echo or a bullet striking metal)
3. contact, usually in order to remind of something; "Ill ping my accountant--April 15 is nearing"
4. hit with a pinging noise; "The bugs pinged the lamp shade"
5. make a short high-pitched sound; "the bullet pinged when they struck the car"
6. the 16th letter of the Roman alphabet (同)p
7. a substance (an atom or molecule or radical or ion) that forms a complex around a central atom
8. a conjugated protein having a carbohydrate component

PrepTutorEJDIC

1. (小銃弾などの)ピュー(ブーン)という音 / ピュー(ブーン)と音がする
2. (最高・最適のものとして)…‘を'『選ぶ』,選抜する,選出する / (人が)『えり抜きの』,精選された / 《名詞の前にのみ用いて》(製品・産物などが)『品質の良い』,粒よりの,高級(上もの)の / (クラブなどが)人選のやかましい,閉鎖的な
3. parking
4. phosphorusの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/10/26 21:36:47」(JST)

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Selectin P ligand
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1G1S
Identifiers
Symbols	SELPLG; CD162; CLA; PSGL-1; PSGL1
External IDs	OMIM: 600738 MGI: 106689 HomoloGene: 2261 ChEMBL: 4183 GeneCards: SELPLG Gene
Gene Ontology Molecular function • receptor binding • protein binding • bacterial cell surface binding Cellular component • plasma membrane • integral to plasma membrane • membrane • integral to membrane Biological process • cell adhesion • blood coagulation • leukocyte migration • leukocyte tethering or rolling • leukocyte adhesive activation • cellular response to interleukin-6 Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6404	20345
Ensembl	ENSG00000110876	ENSMUSG00000048163
UniProt	Q14242	Q3TA56
RefSeq (mRNA)	NM_001206609	NM_009151
RefSeq (protein)	NP_001193538	NP_033177
Location (UCSC)	Chr 12: 109.02 – 109.03 Mb	Chr 5: 113.82 – 113.83 Mb
PubMed search	[1]	[2]

Selectin P ligand, also known as SELPLG or CD162 (cluster of differentiation 162), is a human gene.

SELPLG is the high affinity counter-receptor for P-selectin on myeloid cells and stimulated T lymphocytes. As such, it plays a critical role in the tethering of these cells to activated platelets or endothelia expressing P-selectin. The organization of the SELPG gene closely resembles that of CD43 and the human platelet glycoprotein GpIb-alpha both of which have an intron in the 5-prime-noncoding region, a long second exon containing the complete coding region, and TATA-less promoters.

P-selectin glycoprotein ligand-1 is a glycoprotein found on white blood cells and endothelial cells that binds to P-selectin (P stands for platelet), which is one of a family of selectins that includes E-selectin (endothelial) and L-selectin (leukocyte). Selectins are part of the broader family of cell adhesion molecules. PSGL-1 can bind to all three members of the family but binds best (with the highest affinity) to P-selectin.

Posttranslational modification

PSGL-1 protein requires two distinct posttranslational modifications to gain its selectin binding activity:

• sulfation of tyrosines
• the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans

Function

PSGL-1 is expressed on all white blood cells and plays an important role in the recruitment of white blood cells into inflamed tissue.

White blood cells normally do not interact with the endothelium of blood vessels. However, inflammation causes the expression of cell adhesion molecules (CAM) such as P-selectin on the surface of the blood vessel wall. White blood cells present in flowing blood can interact with CAM. The first step in this interaction process is carried out by PSGL-1 interacting with P-selectin and/or E-selectin on endothelial cells and adherent platelets. This interaction results in "rolling" of the white blood cell on the endothelial cell surface followed by stable adhesion and transmigration of the white blood cell into the inflamed tissue.

References

Further reading

• Furie B, Furie BC (2004). "Role of platelet P-selectin and microparticle PSGL-1 in thrombus formation.". Trends in molecular medicine 10 (4): 171–8. doi:10.1016/j.molmed.2004.02.008. PMID 15059608. 
• Sako D, Chang XJ, Barone KM, et al. (1993). "Expression cloning of a functional glycoprotein ligand for P-selectin.". Cell 75 (6): 1179–86. doi:10.1016/0092-8674(93)90327-M. PMID 7505206. 
• Moore KL, Eaton SF, Lyons DE, et al. (1994). "The P-selectin glycoprotein ligand from human neutrophils displays sialylated, fucosylated, O-linked poly-N-acetyllactosamine.". J. Biol. Chem. 269 (37): 23318–27. PMID 7521878. 
• Veldman GM, Bean KM, Cumming DA, et al. (1995). "Genomic organization and chromosomal localization of the gene encoding human P-selectin glycoprotein ligand.". J. Biol. Chem. 270 (27): 16470–5. doi:10.1074/jbc.270.27.16470. PMID 7541799. 
• Wilkins PP, Moore KL, McEver RP, Cummings RD (1995). "Tyrosine sulfation of P-selectin glycoprotein ligand-1 is required for high affinity binding to P-selectin.". J. Biol. Chem. 270 (39): 22677–80. doi:10.1074/jbc.270.39.22677. PMID 7559387. 
• Sako D, Comess KM, Barone KM, et al. (1995). "A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding.". Cell 83 (2): 323–31. doi:10.1016/0092-8674(95)90173-6. PMID 7585949. 
• Pouyani T, Seed B (1995). "PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus.". Cell 83 (2): 333–43. doi:10.1016/0092-8674(95)90174-4. PMID 7585950. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Li F, Wilkins PP, Crawley S, et al. (1996). "Post-translational modifications of recombinant P-selectin glycoprotein ligand-1 required for binding to P- and E-selectin.". J. Biol. Chem. 271 (6): 3255–64. doi:10.1074/jbc.271.6.3255. PMID 8621728. 
• Guyer DA, Moore KL, Lynam EB, et al. (1996). "P-selectin glycoprotein ligand-1 (PSGL-1) is a ligand for L-selectin in neutrophil aggregation.". Blood 88 (7): 2415–21. PMID 8839831. 
• Goetz DJ, Greif DM, Ding H, et al. (1997). "Isolated P-selectin glycoprotein ligand-1 dynamic adhesion to P- and E-selectin.". J. Cell Biol. 137 (2): 509–19. doi:10.1083/jcb.137.2.509. PMC 2139768. PMID 9128259. 
• Fuhlbrigge RC, Kieffer JD, Armerding D, Kupper TS (1997). "Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells.". Nature 389 (6654): 978–81. doi:10.1038/40166. PMID 9353122. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Snapp KR, Ding H, Atkins K, et al. (1998). "A novel P-selectin glycoprotein ligand-1 monoclonal antibody recognizes an epitope within the tyrosine sulfate motif of human PSGL-1 and blocks recognition of both P- and L-selectin.". Blood 91 (1): 154–64. PMID 9414280. 
• Bennett EP, Hassan H, Mandel U, et al. (1998). "Cloning of a human UDP-N-acetyl-alpha-D-Galactosamine:polypeptide N-acetylgalactosaminyltransferase that complements other GalNAc-transferases in complete O-glycosylation of the MUC1 tandem repeat.". J. Biol. Chem. 273 (46): 30472–81. doi:10.1074/jbc.273.46.30472. PMID 9804815. 
• Wimazal F, Ghannadan M, Müller MR, et al. (2000). "Expression of homing receptors and related molecules on human mast cells and basophils: a comparative analysis using multi-color flow cytometry and toluidine blue/immunofluorescence staining techniques.". Tissue Antigens 54 (5): 499–507. doi:10.1034/j.1399-0039.1999.540507.x. PMID 10599889. 
• Epperson TK, Patel KD, McEver RP, Cummings RD (2000). "Noncovalent association of P-selectin glycoprotein ligand-1 and minimal determinants for binding to P-selectin.". J. Biol. Chem. 275 (11): 7839–53. doi:10.1074/jbc.275.11.7839. PMID 10713099. 
• André P, Spertini O, Guia S, et al. (2000). "Modification of P-selectin glycoprotein ligand-1 with a natural killer cell-restricted sulfated lactosamine creates an alternate ligand for L-selectin.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3400–5. doi:10.1073/pnas.040569797. PMC 16251. PMID 10725346. 
• Frenette PS, Denis CV, Weiss L, et al. (2000). "P-Selectin glycoprotein ligand 1 (PSGL-1) is expressed on platelets and can mediate platelet-endothelial interactions in vivo.". J. Exp. Med. 191 (8): 1413–22. doi:10.1084/jem.191.8.1413. PMC 2193129. PMID 10770806. 
• Woltmann G, McNulty CA, Dewson G, et al. (2000). "Interleukin-13 induces PSGL-1/P-selectin-dependent adhesion of eosinophils, but not neutrophils, to human umbilical vein endothelial cells under flow.". Blood 95 (10): 3146–52. PMID 10807781. 
• Tsuchihashi S, Fondevila C, Shaw GD, et al. (2006). "Molecular characterization of rat leukocyte P-selectin glycoprotein ligand-1 and effect of its blockade: protection from ischemia-reperfusion injury in liver transplantation.". J Immunol 176 (1): 616–24. PMID 16365457. 

External links

• P-selectin glycoprotein ligand-1 at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

UpToDate Contents

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• 2. 冠動脈疾患における血小板の役割 the role of platelets in coronary heart disease
• 3. 炎症の病因における白血球内皮細胞接着 leukocyte endothelial adhesion in the pathogenesis of inflammation
• 4. 冠動脈疾患における血小板糖蛋白（GP）IIb/IIIa受容体拮抗薬に関する
  初期臨床試験 early trials of platelet glycoprotein iib iiia receptor inhibitors in coronary heart disease
• 5. 先天性および後天性血小板機能障害 congenital and acquired disorders of platelet function

English Journal

• 2-Arachidonoylglycerol modulates human endothelial cell/leukocyte interactions by controlling selectin expression through CB1 and CB2 receptors.

• Gasperi V1, Evangelista D1, Chiurchiù V2, Florenzano F3, Savini I1, Oddi S2, Avigliano L1, Catani MV4, Maccarrone M5.
• The international journal of biochemistry & cell biology.Int J Biochem Cell Biol.2014 Jun;51:79-88. doi: 10.1016/j.biocel.2014.03.028. Epub 2014 Apr 8.
• Accumulated evidence points to a key role for endocannabinoids in cell migration, and here we sought to characterize the role of these substances in early events that modulate communication between endothelial cells and leukocytes. We found that 2-arachidonoylglycerol (2-AG) was able to initiate and
• PMID 24721209

• Histopathology and biomarkers in prediction of renal function in children after kidney transplantation.

• Miettinen J1, Helin H2, Pakarinen M3, Jalanko H4, Lauronen J5.
• Transplant immunology.Transpl Immunol.2014 May 5. pii: S0966-3274(14)00029-X. doi: 10.1016/j.trim.2014.04.006. [Epub ahead of print]
• BACKGROUND: Early detection of chronic allograft injury is a major challenge after kidney transplantation (RTx) in adults and children. We correlated the expression of four immunohistochemical biomarkers, P-selectin glycoprotein ligand-1 (PSGL-1), vimentin, α-smooth muscle actin (α-SMA) and collag
• PMID 24801206

• Ischemic Memory Imaging in Nonhuman Primates with Echocardiographic Molecular Imaging of Selectin Expression.

• Davidson BP1, Chadderdon SM2, Belcik JT2, Gupta S2, Lindner JR2.
• Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.J Am Soc Echocardiogr.2014 Apr 25. pii: S0894-7317(14)00220-X. doi: 10.1016/j.echo.2014.03.013. [Epub ahead of print]
• BACKGROUND: Selectins are adhesion molecules that are expressed by the vascular endothelium upon activation and may be an imaging target for detecting myocardial ischemia long after resolution. The aim of this study was to test the hypothesis that molecular imaging of selectins with myocardial contr
• PMID 24774222

Japanese Journal

• エンテロウイルス71受容体としての P-selectin glycoprotein ligand-1 の同定

• 西村 順裕,清水 博之
• ウイルス 59(2), 195-204, 2009-12-01
• NAID 10026383617

• P-selectin glycoprotein ligand-1 contributes to wound healing predominantly as a p-selectin ligand and partly as an e-selectin ligand.

• Tomita Hajime,Iwata Yohei,Ogawa Fumihide,Komura Kazuhiro,Shimizu Kazuhiro,Yoshizaki Ayumi,Hara Toshihide,Muroi Eiji,Yanaba Koichi,Bae Sangjae,Takenaka Motoi,Hasegawa Minoru,Fujimoto Manabu,Sato Shinichi
• The Journal of investigative dermatology 129(8), 2059-2067, 2009-08
• … Although P-selectin glycoprotein ligand-1 (PSGL-1) regulates leukocyte rolling by binding P-selectin, but also binding E- and L-selectins with lower affinity, little is known about a role of PSGL-1 in wound healing. …
• NAID 120001945553

Related Pictures

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★リンクテーブル★

関連記事	「select」「P」「ps」「p」

「select」

　　[★]

• v.

• 選択する、選定する、選抜する、選ぶ

関

choice、choose、elect、elective、opt、option、optional、prefer、selection、selective、single

　

「P」

　　[★]

• プロリン proline
• P波 P wave
• リン phosphorus

　 　 　

「ps」

　　[★]

• ピコ秒

時間単位

関

picosecond、psec

「p」

　　[★]

• ピコ

10の-12乗

関

pico