- 同
- NFAT
- 同
- NFAT
WordNet
- be a contributing factor; "make things factor into a companys profitability"
- any of the numbers (or symbols) that form a product when multiplied together
- an independent variable in statistics
- anything that contributes causally to a result; "a number of factors determined the outcome"
- consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
- resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
- small room in which a monk or nun lives (同)cubicle
- a device that delivers an electric current as the result of a chemical reaction (同)electric cell
- a room where a prisoner is kept (同)jail cell, prison cell
- (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
- any small compartment; "the cells of a honeycomb"
- a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
- an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
- a concept whose truth can be proved; "scientific hypotheses are not facts"
- a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
- a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
- of or relating to or constituting the nucleus of an atom; "nuclear physics"; "nuclear fission"; "nuclear forces"
- (weapons) deriving destructive energy from the release of atomic energy; "nuclear war"; "nuclear weapons"; "atomic bombs" (同)atomic
- constituting or like a nucleus; "annexation of the suburban fringe by the nuclear metropolis"; "the nuclear core of the congregation"
- of or relating to or constituting the nucleus of a cell; "nuclear membrane"; "nuclear division"
PrepTutorEJDIC
- (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
- (刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
- 《所有・所属》…『の』,…のものである,…に属する・《材料・要素》…『でできた』,から成る・《部分》…『の』[『中の』] ・《数量・単位・種類を表す名詞に付いて》…の・《原因・動機》…『で』,のために(because of) ・《主格関係》…『の』,による,によって・《目的格関係》…『を』,の・《同格関係》…『という』・《関係・関連》…『についての』[『の』],の点で・《抽象名詞などと共に》…の[性質をもつ] ・《『It is』+『形』+『of』+『名』+『to』 doの形で,ofの後の名詞を意味上の主語として》・《分離》…『から』・《起原・出所》…『から』[『の』](out of) ・《『名』+『of』+『a』(『an』)+『名』の形で》…のような・《『名』+『of』+『mine』(『yours, his』など独立所有格)の形で》…の…・《時》(1)《副詞句を作って》…に《形容詞句を作って》…の・《時刻》《米》…前(to,《米》before)
- 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
- 『核の』,細胞核の / [『原子』]『核の』
UpToDate Contents
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- 1. T細胞受容体シグナル伝達 t cell receptor signaling
- 2. シクロスポリンおよびタクロリムスの薬理作用および副作用 pharmacology and side effects of cyclosporine and tacrolimus
- 3. 肥満細胞：表面受容体とシグナル伝達 mast cells surface receptors and signal transduction
- 4. 移植免疫 transplantation immunobiology
- 5. 移植片対宿主病の予防および治療に使用される免疫抑制剤の概要 overview of immunosuppressive agents used for prevention and treatment of graft versus host disease
English Journal
- CTRP3 acts as a negative regulator of osteoclastogenesis through AMPK-c-Fos-NFATc1 signaling in vitro and RANKL-induced calvarial bone destruction in vivo.
- Kim JY1, Min JY2, Baek JM2, Ahn SJ2, Jun HY1, Yoon KH3, Choi MK4, Lee MS5, Oh J6.
- Bone.Bone.2015 Oct;79:242-51. doi: 10.1016/j.bone.2015.06.011. Epub 2015 Jun 21.
- Adipokines derived from adipocytes are important factors that act as circulating regulators of bone metabolism. C1q/tumor necrosis factor (TNF)-related Protein-3 (CTRP3) is a novel adipokine with multiple effects such as lowering glucose levels, inhibiting gluconeogenesis in the liver, and increasin
- PMID 26103094
- Expression, Fermentation and Purification of a predicted Intrinsically Disordered region of the transcription factor, NFAT5.
- DuMond JF1, He Y2, Burg MB3, Ferraris JD4.
- Protein expression and purification.Protein Expr Purif.2015 Aug 6. pii: S1046-5928(15)30023-1. doi: 10.1016/j.pep.2015.08.003. [Epub ahead of print]
- Hypertonicity stimulates Nuclear Factor of Activated T-cells 5 (NFAT5) nuclear localization and transactivating activity. Many transcription factors are known to contain intrinsically disordered regions (IDRs) which become more structured with local environmental changes such as osmolality, temperat
- PMID 26256058
- Cardiac Hypertrophy Is Inhibited by a Local Pool of cAMP Regulated by Phosphodiesterase 2.
- Zoccarato A1, Surdo NC2, Aronsen JM3, Fields LA4, Mancuso L5, Dodoni G5, Stangherlin A6, Livie C7, Jiang H8, Sin YY9, Gesellchen F4, Terrin A5, Baillie GS9, Nicklin SA9, Graham D9, Szabo-Fresnais N10, Krall J11, Vandeput F11, Movsesian M11, Furlan L5, Corsetti V5, Hamilton GM12, Lefkimmiatis K2, Sjaastad I3, Zaccolo M13.
- Circulation research.Circ Res.2015 Aug 4. pii: CIRCRESAHA.114.305892. [Epub ahead of print]
- RATIONALE: Chronic elevation of 3'-5'-cyclic adenosine monophosphate (cAMP) levels has been associated with cardiac remodelling and cardiac hypertrophy. However, enhancement of particular aspects of cAMP/protein kinase A (PKA) signalling appears to be beneficial for the failing heart. cAMP is a plei
- PMID 26243800
Japanese Journal
- Suppressive Effect of Tomentosin on the Production of Inflammatory Mediators in RAW264.7 Cells
- Park Hyo-Hyun,Kim Sun-Gun,Kim Mi Jin [他]
- Biological & pharmaceutical bulletin 37(7), 1177–1183, 2014-07
- NAID 40020103606
- Chondroitin-6-sulfate attenuates inflammatory responses in murine macrophages via suppression of NF-κB nuclear translocation.
- Tan Guak-Kim,Tabata Yasuhiko
- Acta biomaterialia 10(6), 2684-2692, 2014-06
- … Inflammation is a host protective response to noxious stimuli, and excessive production of pro-inflammatory mediators by macrophages (mφ) can lead to numerous pathological conditions. … In this study, immunomodulatory effects of immobilized and soluble glycosaminoglycans (GAGs) on mouse-bone-marrow-derived mφ were compared by measuring nitric oxide (NO). …
- NAID 120005439749
- Chemopreventive effect of green tea catechin on rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide
- Kono Takako,Matsushima Yuki,Morita Shosuke
- Journal of
- … Oral cancer treatment may have significant adverse effects on the patient's activities of daily living (ADL) and quality of life (QOL). … In recent years attention has been focused on the use of food for chemoprevention. … (-)-Epigallocatechin-3-gallate (EGCG), which accounts for about half of green tea catechins, is not only a strong antioxidant, but has also been reported to possess anti-tumor and carcinogenesis-inhibiting actions. …
- NAID 110009810297
Related Links
- 細胞内Ca2+濃度の上昇によりホスファターゼであるCN(calcineurin)が活性化され、 細胞質内にリン酸化状態で存在する転写因子NF-AT(nuclear factor of activated T cell )を脱リン酸化し核内へ移行させる。核内へ移行したNF-ATは先述したAP-1と会合しIL-2 ...
Related Pictures
★リンクテーブル★
| リンク元 | 「NFAT」 |
| 関連記事 | 「nuclear」「fact」「factor」「activated」「activate」 |
「NFAT」
- 英
- nuclear factor of activated T cells, NF-AT
- 関
- NFAT family、カルシニューリン、シクロスポリンA、FK506
- 普段は細胞質にあってセリン/スレオニンキナーゼにより核移行配列がリン酸化されており核移行が妨げられている。
- 細胞質の[Ca2+]↑によりカルモジュリンがCa2+を結合しコンフォメーションが変化する。
- Ca2+を結合したカルモジュリンは、セリン/スレオニンホスファターゼであるカルシニューリンに結合する。
- カルモジュリンとの結合によりカルシニューリンは活性化され、NFATを脱リン酸化する。
- 脱リン酸化されたNFATは核に移行し遺伝子発現を行う。
- T細胞ではIL-2の転写に関わっている
「nuclear」
- adj.
- 核の、(生物)細胞核の、(物理)原子核の
「fact」
- n.
「factor」
- n.
「activated」
- adj.
- 活性化の、活性化型の、賦活化の
「activate」
- v.
- 活性化する、賦活化する、賦活する