核細胞質比
WordNet
- give (hair) the appearance of being fuller by using a rat
- a pad (usually made of hair) worn as part of a womans coiffure
- any of various long-tailed rodents similar to but larger than a mouse
- catch rats, especially with dogs
- desert ones party or group of friends, for example, for ones personal advantage
- employ scabs or strike breakers in
- of or relating to or constituting the nucleus of an atom; "nuclear physics"; "nuclear fission"; "nuclear forces"
- (weapons) deriving destructive energy from the release of atomic energy; "nuclear war"; "nuclear weapons"; "atomic bombs" (同)atomic
- constituting or like a nucleus; "annexation of the suburban fringe by the nuclear metropolis"; "the nuclear core of the congregation"
- of or relating to or constituting the nucleus of a cell; "nuclear membrane"; "nuclear division"
- of or relating to cytoplasm (同)cytoplasmatic
- the relative magnitudes of two quantities (usually expressed as a quotient)
- the protoplasm of a cell excluding the nucleus; is full of proteins that control cell metabolism (同)cytol
PrepTutorEJDIC
- 『ネズミ』 / ひきょう者,裏切り者 / ネズミをつかまえる / 《話》(人を)裏切る,密告する《+『on』+『名』〈人〉》
- 『核の』,細胞核の / [『原子』]『核の』
- 細胞質の
- 『比』,比率,『割合』;『比例』
- 細胞質
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/07/13 00:11:14」(JST)
[Wiki en表示]
The correct title of this article is N:C ratio. The substitution or omission of the colon is because of technical restrictions.
The nuclear-cytoplasmic ratio (also variously known as the nucleus:cytoplasm ratio, nucleus-cytoplasm ratio, N:C ratio, or N/C) is a measurement used in cell biology. It is a ratio of the size (i.e., volume) of the nucleus of a cell to the size of the cytoplasm of that cell.[1]
The N:C ratio indicates the maturity of a cell, because as a cell matures the size of its nucleus generally decreases. So, for example, "blast" forms of erythrocytes, leukocytes, and megakaryocytes start with an N:C ratio of 4:1, which decreases as they mature to 2:1 or even 1:1 (with exceptions for mature thrombocytes and erythrocytes, which are anuclear cells, and mature lymphocytes, which only decrease to a 3:1 ratio and often retain the original 4:1 ratio).[1]
An increased N:C ratio is commonly associated with precancerous dysplasia as well as with malignant cells.
See also
- Cell growth#Yeast cell size regulation
- Cytopathology
- Nuclear atypia
- Nuclear pleomorphism
References
- ^ a b Turgeon, Mary Louise (2005). Clinical hematology: theory and procedures. Hagerstwon, MD: Lippincott Williams & Wilkins. p. 67. ISBN 0-7817-5007-5.
Further reading
- Herbert E. Nieburgs (1967). "Nuclear/Cytoplasmic Ratio (N/C) and Nuclear Chromatin". Diagnostic cell pathology in tissue and smears. New York & London: Grune & Stratton. pp. 15–16.
- Takahashi, Masayoshi (1981). Color atlas of cancer cytology (2nd ed.). New York: Igaku-Shoin. pp. 32–34, 50. ISBN 0-89640-050-6.
- John D. Bancroft; Alan Stevens (1982). Theory and practice of histological techniques (2nd ed.). Churchill Livingstone. pp. 438–439.
UpToDate Contents
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English Journal
- Nuclear morphology and c-Jun N-Terminal Kinase 1 expression differentiate serum starved oxidative stress signaling from hydrogen peroxide induced apoptosis in retinal neuronal cell line.
- Basu K, Mukhopadhya A, Ghosh I, Datta K.AbstractOxidative stress induced by serum starvation and hydrogen peroxide (H2O2) exposure, both triggers apoptosis in retinal neuronal cell line (RGC-5). In the present study we tried to examine whether in spite of excess generation of reactive oxygen species (ROS) and apoptosis induction there is any dissimilarity in nuclear morphology and apoptotic signaling pathway in RGC-5 under these two conditions. To address this objective, sub-confluent cells were treated either with H2O2 or maintained in serum free medium (SFM). ROS level was detected along with nuclear morphology and ultrastructural analysis. Generation of excess intracellular ROS, nuclear localization of Bax and Caspase 3 activation along with decrease of cellular viability, confirmed apoptosis induction in RGC-5 by 72 h serum starvation and 500 μM H2O2 exposure for 1 h. Nuclear swelling as supported by nuclear cytoplasmic ratio and conspicuous black spots with nuclear remodeling were observed only upon SFM but not with H2O2 treatment. Serum starvation could not alter JNK1 expression although nuclear translocation and higher level of pJNK was evident. Conversely, H2O2 exposure blocked the expression and activation of JNK1 to pJNK as negligible level of pJNK could be detected in cytoplasm. Despite similar ROS generation in both the conditions, difference in nuclear morphology and JNK1 expression leads to the hypothesis that RGC-5 cells may follow different signalling pathways when challenged with serum starvation and H2O2.
- Cell biology international.Cell Biol Int.2012 Jul 9. [Epub ahead of print]
- Oxidative stress induced by serum starvation and hydrogen peroxide (H2O2) exposure, both triggers apoptosis in retinal neuronal cell line (RGC-5). In the present study we tried to examine whether in spite of excess generation of reactive oxygen species (ROS) and apoptosis induction there is any diss
- PMID 22775755
- Histological correlates of optical coherence tomography in non-melanoma skin cancer.
- Coleman AJ, Richardson TJ, Orchard G, Uddin A, Choi MJ, Lacy KE.SourceMedical Physics Department, Guy's and St Thomas' NHS Foundation Trust, London.
- Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI).Skin Res Technol.2012 Jun 28. doi: 10.1111/j.1600-0846.2012.00626.x. [Epub ahead of print]
- BACKGROUND: Non-melanoma skin cancer (NMSC) is rarely fatal but is now the most common malignancy occurring in white populations, accounting for 70% of the cost of managing skin cancer. Optical coherence tomography (OCT) has the potential to improve diagnostic accuracy and help delineate pre-surgica
- PMID 22738357
Japanese Journal
- 機械学習を用いた肝生検病理画像からの脂肪滴抽出のための一手法(ポスター発表1,計算解剖モデルに基づく診断・治療支援,医用画像処理一般)
- 石川 雅浩,小林 直樹,駒形 英樹,山口 雅浩,阿部 時也,橋口 明典,坂元 亨宇
- 電子情報通信学会技術研究報告. MI, 医用画像 113(410), 103-108, 2014-01-19
- HE染色肝病理標本における肝細胞がんの診断では,細胞核や細胞配列など様々な形態学的特徴が用いられる.これら形態学的特徴を定量化する際に,脂肪滴が問題となる.脂肪滴の生じた領域は,白く抜けるためN/C比や構造情報などの算出が困難となる.そこで,本研究では脂肪滴の多い領域を自動的に検出し除外することを目的として,形状情報に加えて色情報や細胞核の配置等の特徴量を用いた脂肪滴抽出法を開発した.提案法を用い …
- NAID 110009821246
- 甲斐 敬太,花島 克幸,尾形 正也,永石 信二,木戸 伸一
- 日本臨床細胞学会雑誌 53(5), 406-407, 2014
- … Although the diagnosis of endometrial adenocarcinoma was initially considered based on the cytological findings, the low nuclear : cytoplasmic ratio and polarity of the tumor cells prevented a definitive cytological diagnosis. …
- NAID 130004706145
- 小林 裕幸,野嵜 英樹,清水 稔,榊原 巧,奥村 徳夫,岡田 学
- 日本臨床外科学会雑誌 75(1), 223-228, 2014
- 胆嚢原発の腺内分泌細胞癌は稀な疾患であり,予後不良とされている.われわれは,胆嚢癌の診断にて手術を施行し,術後の病理検査にて胆嚢腺内分泌細胞癌と診断された症例を経験したので報告する.症例は77歳の男性で超音波検査にて胆嚢に3×2.5cm大の腫瘍を認めた.腹部CT検査などにて胆嚢癌と診断し手術を施行した.胆嚢体部に腫瘍を認め,肝床1cmを切除する拡大胆嚢摘出術,D2リンパ節郭清を施行した.病理組織検 …
- NAID 130004679192
Related Links
- nuclear-cytoplasmic ratio A crude parameter used in cytology and surgical pathology, in which interphase (i.e., nondividing) nuclei are proportionately larger than the surrounding cytoplasm, a finding which is often increased in ...
- nuclear–cytoplasmic ratio A measure of the size of a cell nucleus in relation to the cytoplasm. The nuclear–cytoplasmic ratio is often used as an index in the comparison of cells from normal and abnormal tissues. For example ...
★リンクテーブル★
[★]
- 英
- nucleocytoplasmic ratio
- 同
- NC比、核/細胞質比、nuclear-cytoplasmic ratio、nucleus:cytoplasm ratio、N:C ratio、N/C、N:C、NC
- NC ratioが大きい → 核の占める割合が大きい、細胞質が萎縮している → 腫瘍細胞
- NC ratioが小さい → 核の占める割合が小さい → 表層の方の角化重層扁平上皮
[★]
- (げっ歯類)ラット、(マウスも含めての総称)ネズミ、ラットの
- 関
- laboratory rat、mouse、Norway rat、Rattus、Rattus norvegicus
[★]
- 関
- cytoplasm、cytoplasma、intracytoplasmic、protoplasm、protoplasmic
[★]
- 関
- cell nuclei、cell nucleus、nuclei、nucleo、nucleus
[★]
- 関
- fraction、percentage、proportion、rate、specific