WordNet

push or move with the nose
a small distance; "my horse lost the race by a nose"
a front that resembles a human nose (especially the front of an aircraft); "the nose of the rocket heated up on reentry"
the front or forward projection of a tool or weapon; "he ducked under the nose of the gun"
the organ of smell and entrance to the respiratory tract; the prominent part of the face of man or other mammals; "he has a cold in the nose" (同)olfactory_organ
a natural skill; "he has a nose for good deals"
a symbol of inquisitiveness; "keep your nose out of it"
the sense of smell (especially in animals); "the hound has a good nose"
advance the forward part of with caution; "She nosed the car into the left lane"
defeat by a narrow margin
undergo a test; "She doesnt test well"
any standardized procedure for measuring sensitivity or memory or intelligence or aptitude or personality etc; "the test was standardized on a large sample of students" (同)mental test, mental testing, psychometric test
the act of undergoing testing; "he survived the great test of battle"; "candidates must compete in a trial of skill" (同)trial
the act of testing something; "in the experimental trials the amount of carbon was measured separately"; "he called each flip of the coin a new trial" (同)trial, run
a hard outer covering as of some amoebas and sea urchins
put to the test, as for its quality, or give experimental use to; "This approach has been tried with good results"; "Test this recipe" (同)prove, try, try out, examine, essay
achieve a certain score or rating on a test; "She tested high on the LSAT and was admitted to all the good law schools"
determine the presence or properties of (a substance)
show a certain characteristic when tested; "He tested positive for HIV"
used to express refusal or denial or disagreement etc or especially to emphasize a negative statement; "no, you are wrong"
a negative; "his no was loud and clear"
referring to the degree to which a certain quality is present; "he was no heavier than a child" (同)no more
not in any degree or manner; not at all; "he is no better today"
quantifier; used with either mass nouns or plural count nouns for indicating a complete or almost complete lack or zero quantity of; "we have no bananas"; "no eggs left and no money to buy any"; "have you no decency?"; "did it with no help"; "Ill get you there in no time"
an examination of the characteristics of something; "there are laboratories for commercial testing"; "it involved testing thousands of children for smallpox"
the act of subjecting to experimental test in order to determine how well something works; "they agreed to end the testing of atomic weapons"
of or secreting or covered with or resembling mucus; "mucous tissue"; "mucous glands of the intestine" (同)mucose

PrepTutorEJDIC

『鼻』 / 《単数形で》(…に対する)『嗅覚』(きゅうかく)《+『for』+『名』》 / (鼻のように)突起した部分;船首,機首 / 《単数形で》(…を)かぎつける力《+『for』+『名』》 / 《副詞[句]を伴って》…‘を'鼻で押す,鼻でさわる(こする) / …‘を'鼻でかぐ,‘を'においをかぐ;…‘を'においで知る / (…の)においをかぐ《+『at』+『名』》 / 《副詞[句]を伴って》(用心しながら)鼻先を向けて進む
(人の能力などの)『試験』,考査,テスト / (物事の)『試験』,検済,試錬,実験《+of+名》 / 化学分析;試薬 / =test match / …‘を'『試験する』,検査する / …‘を'化学分析する / (…の)試験を受ける,試験をする《+for+名》
《名詞の前に置いて》『一つも』(『一人も,少しも』)・・・『ない』 / 《補語につけて》『決して・・・でない』 / 《省略文で》・・・なし;・・・お断り / 《話》少ししか(あまり)・・・ない / (肯定の問いに対して)『いいえ』;(否定の問いに対して)はい,ええ / 《not, norの前に挿入して》『いや』,否 / 《形容詞の前に置その形容詞を否定して》…どころではない / 《比較級の前に置いて》ちっとも…でない,…と全く同じ / 《… or no の形で》…であってもなくても / 《驚き・困惑・不信などを表して》とんでもない / 《単数形で》『拒否』,「『いいえ』」という返事 / 《複数形で》反対[投]票
粘液の,粘液性の;粘液の分泌(ぶんぴつ)する

UpToDate Contents

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1. 水疱性類天疱瘡および粘膜類天疱瘡の臨床的特徴および診断 clinical features and diagnosis of bullous pemphigoid and mucous membrane pemphigoid
2. 鼻症状の原因：概要 etiologies of nasal symptoms an overview
3. 水疱性類天疱瘡および粘膜類天疱瘡の疫学および病因 epidemiology and pathogenesis of bullous pemphigoid and mucous membrane pemphigoid
4. 皮膚の水疱を有する患者に対するアプローチ approach to the patient with cutaneous blisters
5. 成人における全身性エリテマトーデスの臨床症状の概要 overview of the clinical manifestations of systemic lupus erythematosus in adults

English Journal

Reduced microtubule acetylation in cystic fibrosis epithelial cells.

Rymut SM, Harker A, Corey DA, Burgess JD, Sun H, Clancy JP, Kelley TJ.Author information Dept. of Pediatrics, Case Western Reserve Univ., 833 BRB, 10900 Euclid Ave., Cleveland, OH 44106-4948. Thomas.kelley@case.edu.AbstractDysfunctional cystic fibrosis transmembrane conductance regulator (CFTR) leads to many cellular consequences, including perinuclear accumulation of free cholesterol due to impaired endosomal transport. The hypothesis being tested is that CF-related perinuclear cholesterol accumulation due to disrupted endocytic trafficking occurs as a result of reduced microtubule (MT) acetylation. Here, it is identified that acetylated-α-tubulin (Ac-tub) content is reduced by ∼40% compared with respective wild-type controls in both cultured CF cell models (IB3) and primary Cftr-/- mouse nasal epithelial tissue. Histone deacetylase 6 (HDAC6) has been shown to regulate MT acetylation, which provides reasonable grounds to test its impact on reduced Ac-tub content on CF cellular phenotypes. Inhibition of HDAC6, either through tubastatin treatment or HDAC6 knockdown in CF cells, increases Ac-tub content and results in redistributed free cholesterol and reduced stimulation of NF-κB activity. Mechanistically, endoplasmic reticulum stress, which is widely reported in CF and leads to aggresome formation, is identified as a regulator of MT acetylation. F508del CFTR correction with C18 in primary airway epithelial cells restores MT acetylation and cholesterol transport. A significant role for phosphatidyl inositol-3 kinase p110α is also identified as a regulator of MT acetylation.
American journal of physiology. Lung cellular and molecular physiology.Am J Physiol Lung Cell Mol Physiol.2013 Sep 15;305(6):L419-31. doi: 10.1152/ajplung.00411.2012. Epub 2013 Jul 19.
Dysfunctional cystic fibrosis transmembrane conductance regulator (CFTR) leads to many cellular consequences, including perinuclear accumulation of free cholesterol due to impaired endosomal transport. The hypothesis being tested is that CF-related perinuclear cholesterol accumulation due to disrupt
PMID 23873844

A role for anti-BP180 autoantibodies in chronic rhinosinusitis.

Jeffe JS, Seshadri S, Hamill KJ, Huang JH, Carter R, Suh L, Hulse KE, Norton J, Conley DB, Chandra RK, Kern RC, Jones JC, Schleimer RP, Tan BK.AbstractOBJECTIVES/HYPOTHESIS: Chronic Rhinosinusitis (CRS) is accompanied by evidence of a vigorous adaptive immune response, and emerging studies demonstrate that some nasal polyps manifest a polyclonal autoantibody response. We previously found that antibodies against BP180, a component of the hemidesmosome complex and the dominant epitope in autoimmune bullous pemphigoid, were found at elevated levels in nasal polyp tissue. Given the critical role of hemidesmosomes in maintaining epithelial integrity, we sought to investigate the distribution of BP180 in nasal tissue and evaluate for evidence of systemic autoimmunity against this antigen in CRS.
The Laryngoscope.Laryngoscope.2013 Sep;123(9):2104-11.
OBJECTIVES/HYPOTHESIS: Chronic Rhinosinusitis (CRS) is accompanied by evidence of a vigorous adaptive immune response, and emerging studies demonstrate that some nasal polyps manifest a polyclonal autoantibody response. We previously found that antibodies against BP180, a component of the hemidesmos
PMID 24167818

Decreases in adrenomedullin expression and ciliary beat frequency in the nasal epithelium in tubal pregnancy.

O WS, Li HW, Liao SB, Cheung AN, Ng EH, Yeung WS, Ho JC, Tang F.Author information Department of Anatomy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China. owaisum@hku.hkAbstractOBJECTIVE: To study adrenomedullin (ADM) expression and its relation to ciliary beat frequency (CBF) in the nasal mucociliated epithelium in tubal ectopic pregnancy (tEP).
Fertility and sterility.Fertil Steril.2013 Aug;100(2):459-63.e1. doi: 10.1016/j.fertnstert.2013.04.007. Epub 2013 May 10.
OBJECTIVE: To study adrenomedullin (ADM) expression and its relation to ciliary beat frequency (CBF) in the nasal mucociliated epithelium in tubal ectopic pregnancy (tEP).DESIGN: Experimental study.SETTING: University teaching hospital.PATIENT(S): Women with tEP and normal intrauterine pregnancy mat
PMID 23663996

Japanese Journal

Seasonal Variation in Perceived Indoor Environment and Nonspecific Symptoms in a Temperate Climate

Mizoue Tetsuya,Andersson Kjell,Reijula Kari [他],FEDELI Cecilia
Journal of occupational health 46(4), 303-309, 2004-06
… Seasonal effects on the perceived indoor environment and SBS symptoms were investigated with a parametric test for repeated measurement of categorical data. … Symptoms in the mucous membrane (eyes, nose, and throat) and skin increased considerably in the winter and spring (p for season, <0.05), whereas general symptoms varied little, but such seasonality of symptoms was not modified by the building factor. …
NAID 110003722963

スギ花粉飛散数と症状との関係 : 臨床的観察並びに連続誘発による検討

吉田博一,清水宏明,深美悟
アレルギー 45(1), 49-61, 1996-01-30
花粉観測をもとに, 花粉飛散状況と症状の出現時期との関係, 症状経過との関係について詳細に検討した. 症状出現日と花粉数との関係を見ると, 累積発症率と累積花粉数の平方根との間には高い正の相関関係が認められた. また, 初観測日から飛散開始日までの期間が長いほど, 飛散開始日までの発症率が高いことがわかった. 症状経過と花粉数との関係では, 症状スコアと累積花粉数の平方根との間に正の相関関係が認め …
NAID 110002417727

鼻におけるIgEによる反応の生体防御作用

奥田稔,海野徳二
日本耳鼻咽喉科学会会報 79(6), 667-669, 1976
… Immunoglobulins of different classes are known to play a role in humoral defense mechanism, and Immunoglobulin E, without any actual evidence, is also expected to perform the same function.From the point of the defensive role, the present study was undertaken in nasal allergy by observing the way in which powdered carbon particles previously insufflated in the nasal cavity are rapidly removed in the nasal provocation test with causative allergen extract. …
NAID 130000809303