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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/26 01:52:37」(JST)

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Niceritrol is a niacin derivative used as a hypolipidemic agent. It is an ester of pentaerythritol and nicotinic acid, has general properties similar to those of nicotinic acid (Nicotinamide), to which it is slowly hydrolysed. Niceritrol has been used as a lipid regulating drug in hyperlipidaemias and as a vasodilator in the treatment of peripheral vascular disease. ^[1]^[2]

References

^ Owada A., Suda S, Hata T. (2003). "Antiproteinuric effect of niceritrol, a nicotinic acid derivative, in chronic renal disease with hyperlipidemia: a randomized trial.". Am J Med 114 (5): 347–53. PMID 12714122.
^ Truven Health Analytics Inc. (May 8, 2008). "Niceritrol". Micromedexsolutions.com. Retrieved December 14, 2014.

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English Journal

A novel method aimed at counteracting the side effects caused by prostaglandin e2 deficiency during non-steroidal anti-inflammatory drug therapy.

Gargaun S, Gargaun L1.
Anti-inflammatory & anti-allergy agents in medicinal chemistry.Antiinflamm Antiallergy Agents Med Chem.2014;13(2):121-7.
BACKGROUND: Prostaglandin E2 (PGE2) plays key physiological roles within the body's organs and the systemic environment. Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the biosynthesis of PGE2, which can lead to global PGE2 deficiency, resulting in serious side effects in the gastrointestina
PMID 24383936

Successful treatment of lipoprotein glomerulopathy in a daughter and a mother using niceritrol.

Hamatani H1, Hiromura K, Kobatake K, Yoshida H, Kobayashi S, Yoneda N, Kayakabe K, Matsumoto T, Kuroiwa T, Ueki K, Nojima Y.
Clinical and experimental nephrology.Clin Exp Nephrol.2010 Dec;14(6):619-24. doi: 10.1007/s10157-010-0333-9. Epub 2010 Sep 15.
We report two patients, a daughter and a mother, with lipoprotein glomerulopathy (LPG) who were successfully treated with niceritrol. Both patients carried a mutation in the apolipoprotein E (apoE) gene known as ApoE Tokyo/Maebashi. The daughter was found to have proteinuria at the age of 4 years. F
PMID 20842518

Binder blinders-niacin of omission?

Bostom AG.
American journal of kidney diseases : the official journal of the National Kidney Foundation.Am J Kidney Dis.2010 Apr;55(4):628-30. doi: 10.1053/j.ajkd.2009.12.015. Epub 2010 Jan 15.
PMID 20079958

Japanese Journal

Successful treatment of lipoprotein glomerulopathy in a daughter and a mother using niceritrol

HAMATANI Hiroko,HIROMURA Keiju,KOBATAKE Keiko,YOSHIDA Hiroaki,KOBAYASHI Satsuki,YONEDA Naohiro,KAYAKABE Ken,MATSUMOTO Takayuki,KUROIWA Takashi,UEKI Kazue,NOJIMA Yoshihisa
Clinical and experimental nephrology 14(6), 619-624, 2010-12-01
NAID 10029321422

Antiproteinuric effect of niceritrol, a nicotinic acid derivative, in chronic renal disease with hyperlipidemia : a randomized trial

OWADA A
Am J Med 114, 347-353, 2003
NAID 30008545662

血液透析患者におけるニセリトロール服用時の血中ニコチン酸濃度

雑賀保至,児玉直也,木村圭吾,藤井良一,大谷晴久,宗正敏,味村啓司,前田孝夫,湯川進
The Japanese journal of nephrology = / 日本腎臓学会 [編集] 41(4), 430-435, 1999-06-25
NAID 10005248201

Related Pictures

★リンクテーブル★

リンク元	「ニコチン酸系薬」「ニセリトロール」

「ニコチン酸系薬」

Niceritrol
Systematic (IUPAC) name
	3-[(pyridin-3-yl)carbonyloxy]-2,2-bis({[(pyridin-3-yl)carbonyloxy]methyl})propyl pyridine-3-carboxylate
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
ATC code	C10AD01
PubChem	CID: 4476
ChemSpider	4321
UNII	F54EHJ34MV
KEGG	D01754
Chemical data
Formula	C29H24N4O8
Molecular mass	556.523 g/mol
	SMILES C1=CC(=CN=C1)C(=O)OCC(COC(=O)C2=CN=CC=C2)(COC(=O)C3=CN=CC=C3)COC(=O)C4=CN=CC=C4 ;
	InChI InChI=1S/C29H24N4O8/c34-25(21-5-1-9-30-13-21)38-17-29(18-39-26(35)22-6-2-10-31-14-22,19-40-27(36)23-7-3-11-32-15-23)20-41-28(37)24-8-4-12-33-16-24/h1-16H,17-20H2 ; Key:KUEUWHJGRZKESU-UHFFFAOYSA-N ;
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高脂血症治療薬

あまり使われないらしい