単クローン性免疫グロブリン血症
WordNet
- a disturbance in the synthesis of immunoglobulins; proteins having antibody activity increase greatly in the blood
- forming or derived from a single clone
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/05/02 17:34:58」(JST)
[Wiki en表示]
Monoclonal gammopathy |
Classification and external resources |
Specialty |
oncology |
ICD-10 |
D47.2 |
ICD-O |
M9765/1 |
[edit on Wikidata]
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Monoclonal gammopathy is a synonym for paraproteinemia. These are usually found in association with hematologic neoplasms, especially multiple myeloma. They also occur in other benign and malignant conditions.
External links
- Educational Resource for Monoclonal Gammopathies
- Monoclonal gammopathy of undetermined significance (MGUS) - Mayo clinic
Immunoproliferative immunoglobulin disorders (D89, 273)
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PCDs/PP |
- Plasmacytoma
- Multiple myeloma (Plasma cell leukemia)
- MGUS
- IgM (Macroglobulinemia/Waldenström's macroglobulinemia)
- heavy chain (Heavy chain disease)
- light chain (Primary amyloidosis)
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Other hypergammaglobulinemia |
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Hematological malignancy/leukemia histology (ICD-O 9590–9989, C81–C96, 200–208)
Lymphoid/Lymphoproliferative, Lymphomas/Lymphoid leukemias (9590–9739, 9800–9839)
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B cell
(lymphoma,
leukemia)
(most CD19
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By
development/
marker |
TdT+ |
- ALL (Precursor B acute lymphoblastic leukemia/lymphoma)
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CD5+ |
- naive B cell (CLL/SLL)
- mantle zone (Mantle cell)
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CD22+ |
- Prolymphocytic
- CD11c+ (Hairy cell leukemia)
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CD79a+ |
- germinal center/follicular B cell (Follicular
- Burkitt's
- GCB DLBCL
- Primary cutaneous follicle center lymphoma)
- marginal zone/marginal zone B-cell (Splenic marginal zone
- MALT
- Nodal marginal zone
- Primary cutaneous marginal zone lymphoma)
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RS (CD15+, CD30+) |
- Classic Hodgkin's lymphoma (Nodular sclerosis)
- CD20+ (Nodular lymphocyte predominant Hodgkin's lymphoma)
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PCDs/PP
(CD38+/CD138+) |
- see immunoproliferative immunoglobulin disorders
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By infection |
- KSHV (Primary effusion)
- EBV (Lymphomatoid granulomatosis
- Post-transplant lymphoproliferative disorder)
- HIV (AIDS-related lymphoma)
- Helicobacter pylori (MALT lymphoma)
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Cutaneous |
- Diffuse large B-cell lymphoma
- Intravascular large B-cell lymphoma
- Primary cutaneous marginal zone lymphoma
- Primary cutaneous immunocytoma
- Plasmacytoma
- Plasmacytosis
- Primary cutaneous follicle center lymphoma
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T/NK |
T cell
(lymphoma,
leukemia)
(most CD3
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By
development/
marker |
- TdT+: ALL (Precursor T acute lymphoblastic leukemia/lymphoma)
- prolymphocyte (Prolymphocytic)
- CD30+ (Anaplastic large-cell lymphoma
- Lymphomatoid papulosis type A)
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Cutaneous |
MF+variants |
- indolent: Mycosis fungoides
- Pagetoid reticulosis
- Granulomatous slack skin
aggressive: Sézary disease
- Adult T-cell leukemia/lymphoma
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Non-MF |
- CD30-: Non-mycosis fungoides CD30− cutaneous large T-cell lymphoma
- Pleomorphic T-cell lymphoma
- Lymphomatoid papulosis type B
- CD30+: CD30+ cutaneous T-cell lymphoma
- Secondary cutaneous CD30+ large-cell lymphoma
- Lymphomatoid papulosis type A
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Other
peripheral |
- Hepatosplenic
- Angioimmunoblastic
- Enteropathy-associated T-cell lymphoma
- Peripheral T-cell lymphoma not otherwise specified (Lennert lymphoma)
- Subcutaneous T-cell lymphoma
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By infection |
- HTLV-1 (Adult T-cell leukemia/lymphoma)
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NK cell/
(most CD56) |
- Aggressive NK-cell leukemia
- Blastic NK cell lymphoma
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T or NK |
- EBV (Extranodal NK-T-cell lymphoma/Angiocentric lymphoma)
- Large granular lymphocytic leukemia
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Lymphoid+
myeloid |
- Acute biphenotypic leukaemia
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Lymphocytosis |
- Lymphoproliferative disorders (X-linked lymphoproliferative disease
- Autoimmune lymphoproliferative syndrome)
- Leukemoid reaction
- Diffuse infiltrative lymphocytosis syndrome
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Cutaneous lymphoid hyperplasia |
- Cutaneous lymphoid hyperplasia
- with bandlike and perivascular patterns
- with nodular pattern
- Jessner lymphocytic infiltrate of the skin
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UpToDate Contents
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English Journal
- Quantitative analysis of CKS1B mRNA expression and copy number gain in patients with plasma cell disorders.
- Stella F1, Pedrazzini E2, Baialardo E3, Fantl DB4, Schutz N4, Slavutsky I5.
- Blood cells, molecules & diseases.Blood Cells Mol Dis.2014 Sep;53(3):110-7. doi: 10.1016/j.bcmd.2014.05.006. Epub 2014 Jun 25.
- In this study, we have examined CKS1B gene expression and copy number in a total of 114- patients at diagnosis: 83 with multiple myeloma (MM) and 31 with monoclonal gammopathy of undetermined significance (MGUS). Results were correlated with cytogenetics, FISH and clinical characteristic. Significan
- PMID 24973170
- IgG kappa monoclonal gammopathy of undetermined significance presenting as acquired type III Von Willebrand syndrome.
- Howard CR1, Lin TL, Cunningham MT, Lipe BC.
- Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.Blood Coagul Fibrinolysis.2014 Sep;25(6):631-3. doi: 10.1097/MBC.0000000000000112.
- Acquired von Willebrand syndrome (AVWS) is a rare bleeding disorder associated with hematoproliferative disorders, autoimmune conditions, neoplasia and cardiovascular disorders that often present a diagnostic challenge. Monoclonal gammopathy of undetermined significance (MGUS) is one of the most com
- PMID 24686099
- Physiopathology of necrobiotic xanthogranuloma with monoclonal gammopathy.
- Szalat R1, Pirault J, Fermand JP, Carrié A, Saint-Charles F, Olivier M, Robillard P, Frisdal E, Villard EF, Cathébras P, Bruckert E, Chapman MJ, Giral P, Guerin M, Lesnik P, Goff WL.
- Journal of internal medicine.J Intern Med.2014 Sep;276(3):269-284. doi: 10.1111/joim.12195. Epub 2014 Feb 10.
- RATIONALE: Xanthomatosis associated with monoclonal gammopathy includes hyperlipidaemic xanthoma (HX), normolipidaemic xanthoma (NX) and necrobiotic xanthogranuloma (NXG). All three pathologies are characterized by skin or visceral lesions related to cholesterol accumulation, monoclonal immunoglobul
- PMID 24428816
Japanese Journal
- 多発性骨髄腫と腎障害 (特集 多発性骨髄腫の病態と最新治療 : 基礎と臨床の最新情報) -- (病態)
- Monoclonal gammopathy of renal significance(腎障害を伴うM蛋白血症)の診断
- Bridoux Frank,Leung Nelson,Hutchison Colin A. [他]
- Kidney international selections : official journal of the International Society of Nephrology 13(3), 89-103, 2015
- NAID 40020550162
- Thrombosis in Lymphoma Patients and in Myeloma Patients
- Yokoyama Kenji
- The Keio Journal of Medicine advpub(0), 2015
- … The incidence of arterial thrombosis is also increased in patients with myeloma and monoclonal gammopathy of undetermined significance. …
- NAID 130005088825
Related Links
- Monoclonal gammopathy. 18 likes · 0 talking about this. Monoclonal gammopathy is a synonym for paraproteinemia. These are usually found in association with haemic neoplasms, especially multiple myeloma. They also occur in ...
- Monoclonal gammopathy of undetermined significance (MGUS , unknown or uncertain may be substituted for undetermined), formerly benign monoclonal gammopathy, is a condition in which a paraprotein is found in the blood during ...
Related Pictures
★リンクテーブル★
[★]
- 英
- monoclonal gammopathy MG
- 同
- 単クローン性高免疫グロブリン血症 monoclonal hyperimmunoglobulinemia、単クローン性高ガンマグロブリン血症 単クローン性高γグロブリン血症 monoclonal hypergammaglobulinemia、M蛋白血症 M proteinemia
- 関
- 高γグロブリン血症
Clasification WCH.2566
- monoclonal gammopathy of undetermined significance
- benign(IgG, IgA, IgD, IgM, and, rarely, free light chains)
- associated with neoplasms of cell types not known to produce M-proteins
- biclonal gammopathy
- idiopathic Nence Jones proteinuria
- malignant monoclonal gammopathies
-
- overt multiple myeloma
- smoldering multiple myeloma
- plasma cell leukemia
- nonsecretory myeloma
- IgD myeloma
- POEMS: polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, skin changes (osteosclerotic myeloma)
- solitary plsmacytoma of bone
- extramedullary plamacytoma
- malignant lymphoproliferative disorders
- γ heary chain disease
- α heary chain disease
- μ heary chain disease
- primary amyloidosis
- with multiple myeloma (secondary, localized, and familial amyloidosis with no M-protein)
frequency WCH.2567
- monoclonal gammopathy of underteermined significance: 62%
- multiple myeloma: 16%
- amyloidosis: 8%
- lymphoproliferative: 3%
- smoldering multiple myeloma: 4%
- solitary or extramedullary: 1%
- Walderstrom maroglobulinemia: 3%
- other: 3%
[★]
[★]
- 同
- monoclonal immunoglobulin disorders, monoclonal gammopathy, monoclonal immunoglobulinopathy
[★]
良性M蛋白血症、良性単クローン性γグロブリン異常症
[★]
高ガンマグロブリン血症、免疫グロブリン血症、異常γグロブリン血症
- 関
- dysgammaglobulinemia、hypergammaglobulinemia
[★]
- 関
- monoclonality、monoclone