- 関
- monoclonality、monoclone
WordNet
- forming or derived from a single clone
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/01/09 08:34:18」(JST)
[Wiki en表示]
Monoclonal cells are defined as a group of cells produced from a single ancestral cell by repeated cellular replication. Thus they can be said to form a single "clone".[1] The term monoclonal comes from the Ancient Greek monos, meaning "alone" or "single", and klon, denoting "twig".[2]
The process of replication can occur in vivo, or may be stimulated in vitro for laboratory manipulations. The use of the term typically implies that there is some method to distinguish between the cells of the original population from which the single ancestral cell is derived, such as a random genetic alteration, which is inherited by the progeny.
The most common usages of this term are:
- Monoclonal antibodies: A single hybridoma cell, which by chance includes the appropriate V(D)J recombination to produce the desired antibody, is cloned to produce a large population of identical cells. In informal laboratory jargon the monoclonal antibodies isolated from cell culture supernatants of these hybridoma clones (hybridoma "lines") are simply called "monoclonals".
- Monoclonal neoplasms (tumors): A single aberrant cell which has undergone an oncogenic event reproduces itself into a large cancerous mass.
- Monoclonal Plasma Cells: Also called Plasma cell dyscrasia, which a single aberrant plasma cell which has undergone an event and reproduces itself, in some cases is cancerous.
References
- ^ "Medterms dictionary definition".
- ^ monoclonal. (n.d.) Mosby's Medical Dictionary, 8th edition. (2009). Retrieved August 23 2016 from http://medical-dictionary.thefreedictionary.com/monoclonal
UpToDate Contents
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English Journal
- Rapid and quantitative detection of 4(5)-methylimidazole in caramel colours: A novel fluorescent-based immunochromatographic assay.
- Wu X1, Huang M1, Yu S2, Kong F1.
- Food chemistry.Food Chem.2016 Jan 1;190:843-7. doi: 10.1016/j.foodchem.2015.06.037. Epub 2015 Jun 15.
- A novel fluorescence-based immunochromatographic assay (ICA) for rapid detecting 4(5)-methylimidazole (4-MI) is presented in this study. In our work, the conjugates of fluorescent microspheres (FMs) and 4-MI monoclonal antibody were used as probe for ICA. Under optimal conditions, a standard curve o
- PMID 26213047
- Affinity maturation of single-chain variable fragment specific for aflatoxin B1 using yeast surface display.
- Min WK1, Kim SG2, Seo JH3.
- Food chemistry.Food Chem.2015 Dec 1;188:604-11. doi: 10.1016/j.foodchem.2015.04.117. Epub 2015 May 8.
- As aflatoxin B1 is one of the most toxic mycotoxins, it is important to detect and to quantify aflatoxin B1 accurately by immunological methods. To enhance aflatoxin B1-binding affinity of the single-chain variable fragment, yeast surface display technique combined with fluorescence-activated cell s
- PMID 26041237
- Development of a novel biosensor based on F0F1-ATPase for the detection of 2-dodecylcyclobutanone in irradiated beef.
- Zhao Y1, Ha Y1, Yue J2, Wang F3.
- Food chemistry.Food Chem.2015 Dec 1;188:320-4. doi: 10.1016/j.foodchem.2015.04.142. Epub 2015 May 1.
- A novel biosensor regulated by the rotator of F0F1-ATPase was developed to analyze 2-dodecylcyclobutanone (2-DCB) to detect γ-ray irradiated beef rapidly. The biosensor was assembled by conjugating 2-DCB monoclonal antibodies with the "rotator" ε-subunit of F0F1-ATPase within chromatophores throug
- PMID 26041198
Japanese Journal
- Comparison of the localization of tetrodotoxin between wild pufferfish Takifugu rubripes juveniles and hatchery-reared juveniles with tetrodotoxin administration
- Okita Kogen,Takatani Tomohiro,Nakayasu Junichi,Yamazaki Hideki,Sakiyama Kazutaka,Ikeda Koichi,Arakawa Osamu,Sakakura Yoshitaka
- Toxicon 71, 128-133, 2013-09-01
- … To reveal the accumulation profile of tetrodotoxin (TTX) in pufferfish Takifugu rubripes juveniles, we compared the localization of TTX in various tissues among wild juveniles and hatchery-reared juveniles with or without TTX administration using immunohistochemical technique with anti-TTX monoclonal antibody. …
- NAID 120005311927
- Generation of functional antibodies for mammalian membrane protein crystallography.
- Hino Tomoya,Iwata So,Murata Takeshi
- Current opinion in structural biology 23(4), 563-568, 2013-08-00
- … however, it is widely known that the generation of mouse monoclonal antibodies that recognize the conformational epitopes of mammalian integral membrane proteins is typically difficult. …
- NAID 120005312201
- Development of a highly sensitive three-dimensional gel electrophoresis method for characterization of monoclonal protein heterogeneity
- Nakano Keiichi,Tamura Shogo,Otuka Kohei,Niizeki Noriyasu,Shigemura Masahiko,Shimizu Chikara,Matsuno Kazuhiko,Kobayashi Seiichi,Moriyama Takanori
- Analytical Biochemistry 438(2), 117-123, 2013-07-15
- … Three-dimensional gel electrophoresis (3-DE), which combines agarose gel electrophoresis and isoelectric focusing/SDS–PAGE, was developed to characterize monoclonal proteins (M-proteins). …
- NAID 120005311827
Related Links
- Monoclonal gammopathy of undetermined significance (MGUS) is a clinically asymptomatic premalignant clonal plasma cell or lymphoplasmacytic proliferative disorder. It is defined by the presence of a serum monoclonal protein (M ...
- Monoclonal antibodies are typically made by cell culture that involves fusing myeloma cells with the spleen cells from a mouse immunized with the desired antigen. Rabbit B-cells can be used to form a rabbit hybridoma. Polyethylene ...
★リンクテーブル★
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- 英
- monoclone、monoclonal
- 関
- 単クローン性、モノクローナル、モノクローン、モノクロナル
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- 英
- monoclonality、monoclonal
- 関
- 単クローン、モノクローナル、モノクロナル
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- 英
- monoclonal
- 関
- 単クローン、単クローン性、モノクローナル
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- 英
- monoclonal
- 関
- 単クローン、単クローン性、モノクロナル
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- 関
- monoclonal
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ヒト化モノクローン抗体、ヒト化単クローン抗体
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- 関
- monoclonal
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