WordNet

make or undergo a transition (from one state or system to another); "The airline transitioned to more fuel-efficient jets"; "The adagio transitioned into an allegro"
a musical passage moving from one key to another (同)modulation
a change from one place or state or subject or stage to another
a passage that connects a topic to one that follows
cause to convert or undergo a transition; "the company had to transition the old practices to modern technology"

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(…から…へ)移り変わること,変遷;(…から…への)過渡期《+from+名+to+名》

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/04/29 21:47:03」(JST)

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In developmental biology, midblastula or midblastula transition (MBT) is a stage during the blastula stage of embryonic development in which zygotic gene transcription is activated. There are three major characteristics of pre-MBT embryos. Firstly, all of the embryonic cells undergo cell division at the same time.^[1] Secondly, zygotic chromatin is condensed, hypo-acetylated and H3 methylated,^[2] indicating that most of the genes are in a repressed heterochromatic state. Finally, embryos are observed to translate only maternally inherited mRNA, i.e. that mRNA which is present in the oocyte when it is fertilised.^[3] The mRNA is localised in different parts of the oocyte, so that as the embryo divides it is segregated into different cells. This segregation is thought to underlie much of the differentiation of cells that occurs after MBT. Once MBT has taken place, the embryo begins to transcribe its own DNA, cells become motile and cell division becomes asynchronous. Since the cells are now transcribing their own DNA, this stage is where differential expression of paternal genes is first observed.

Timing

The timing of MBT varies between different organisms. Zebrafish MBT occurs at cycle 10,^[4] whilst it occurs at cycle 13 in both Xenopus and Drosophila. Cells are thought to time the MBT by measuring the nucleocytoplasmic ratio, which is effectively the ratio between the volume of cytosol and the amount of DNA. Evidence for this hypothesis comes from the observation that the timing of MBT can be sped up by adding extra DNA,^[5] or by halving the amount of cytoplasm.^[6] The exact method by which the cell achieves this control is unknown, but it is thought to involve a cytosolic protein. In Drosophila, the zinc-finger transcription factor Zelda is bound to regulatory regions of genes expressed by the zygote,^[7] and in zebrafish, the homeodomain protein Pou5f1 (an ortholog of mammalian Oct4) has an analogous role.^[8] Without the function of these proteins MBT gene expression synchrony is disrupted, but particular mechanisms of coordinating the timing of gene expression are under investigation.

References

^ Masui Y, Wang P (1998). "Cell cycle transition in early embryonic development of Xenopus laevis" (PDF). Biol. Cell 90 (8): 537–548. doi:10.1016/S0248-4900(99)80011-2. PMID 10068998.
^ Meehana R, Dunicana D, Ruzova A, Pennings S (2005). "Epigenetic silencing in embryogenesis". Exp. Cell Biol. 309 (2): 241–249. doi:10.1016/j.yexcr.2005.06.023. PMID 16112110.
^ Sibon O, Stevenson V, Theurkauf W (1997). "DNA-replication checkpoint control at the Drosophila midblastula transition". Nature 388 (6637): 93–97. doi:10.1038/40439. PMID 9214509.
^ Kane D, Kimmel C (1993). "The zebrafish midblastula transition". Development 119 (2): 447–456. PMID 8287796.
^ Mita I, Obata C (1984). "Timing of early morphogenetic events in tetraploid starfish embryos". J. Exp. Zool. 229 (2): 215–222. doi:10.1002/jez.1402290206.
^ Mita I (1983). "Studies on factors affecting the timing of early morphogenetic events during starfish embryogenesis". J. Exp. Zool. 225 (2): 293–9. doi:10.1002/jez.1402250212.
^ Harrison, MM; Li, XY; Kaplan, T; Botchan, MR; Eisen, MB (Oct 2011). "Zelda binding in the early Drosophila melanogaster embryo marks regions subsequently activated at the maternal-to-zygotic transition". PLoS Genet 7 (10): e1002266. doi:10.1371/journal.pgen.1002266.
^ Leichsenring, M; Maes, J; Mössner, R; Driever, W; Onichtchouk, D (2013). "Pou5f1 transcription factor controls zygotic gene activation in vertebrates". Science 341 (6149): 1005–9. doi:10.1126/science.1242527.

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English Journal

Cell cycle control in the early embryonic development of aquatic animal species.

Siefert JC1, Clowdus EA1, Sansam CL2.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.Comp Biochem Physiol C Toxicol Pharmacol.2015 Oct 17. pii: S1532-0456(15)00134-9. doi: 10.1016/j.cbpc.2015.10.003. [Epub ahead of print]
The cell cycle is integrated with many aspects of embryonic development. Not only is proper control over the pace of cell proliferation important, but also the timing of cell cycle progression is coordinated with transcription, cell migration, and cell differentiation. Due to the ease with which the
PMID 26475527

Comparative and phylogenetic perspectives of the cleavage process in tailed amphibians.

Desnitskiy AG1, Litvinchuk SN2.
Zygote (Cambridge, England).Zygote.2015 Oct;23(5):722-31. doi: 10.1017/S0967199414000379. Epub 2014 Sep 2.
The order Caudata includes about 660 species and displays a variety of important developmental traits such as cleavage pattern and egg size. However, the cleavage process of tailed amphibians has never been analyzed within a phylogenetic framework. We use published data on the embryos of 36 species
PMID 25180466

RAD18 Is a Maternal Limiting Factor Silencing the UV-Dependent DNA Damage Checkpoint in Xenopus Embryos.

Kermi C1, Prieto S1, van der Laan S1, Tsanov N1, Recolin B1, Uro-Coste E2, Delisle MB2, Maiorano D3.
Developmental cell.Dev Cell.2015 Aug 10;34(3):364-72. doi: 10.1016/j.devcel.2015.06.002. Epub 2015 Jul 23.
In early embryos, the DNA damage checkpoint is silent until the midblastula transition (MBT) because of maternal limiting factors of unknown identity. Here we identify the RAD18 ubiquitin ligase as one such factor in Xenopus. We show, in vitro and in vivo, that inactivation of RAD18 function lead
PMID 26212134