メタネフリン
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/06/24 00:37:06」(JST)
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This article is about Specific molecule "metanephrine". For Metanephrines group, see Metanephrines.
Metanephrine
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Names |
IUPAC name
4-(1-hydroxy-2-methylamino-ethyl)-2-methoxy-phenol
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Identifiers |
CAS Registry Number
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5001-33-2 Y |
ChEMBL |
ChEMBL775 Y |
ChemSpider |
19844 Y |
InChI
-
InChI=1S/C10H15NO3/c1-11-6-9(13)7-3-4-8(12)10(5-7)14-2/h3-5,9,11-13H,6H2,1-2H3 Y
Key: JWJCTZKFYGDABJ-UHFFFAOYSA-N Y
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InChI=1/C10H15NO3/c1-11-6-9(13)7-3-4-8(12)10(5-7)14-2/h3-5,9,11-13H,6H2,1-2H3
Key: JWJCTZKFYGDABJ-UHFFFAOYAB
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IUPHAR/BPS
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6644 |
Jmol-3D images |
Image |
MeSH |
Metanephrine |
PubChem |
21100 |
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Properties |
Chemical formula
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C10H15NO3 |
Molar mass |
197.231 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Y verify (what is: Y/N?) |
Infobox references |
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Metanephrine (metadrenaline) is a metabolite of epinephrine (adrenaline) created by action of catechol-O-methyl transferase on epinephrine. An article in the Journal of the American Medical Association, 2002, indicated that the measurement of plasma free levels of the metanephrines group of molecules (including metanephrine and normetanephrine) is the best tool in the diagnosis of pheochromocytoma, an adrenal medullary neoplasm.[1]
References
- ^ Lenders J, Pacak K, Walther M, Linehan W, Mannelli M, Friberg P, Keiser H, Goldstein D, Eisenhofer G (2002). "Biochemical diagnosis of pheochromocytoma: which test is best?". JAMA 287 (11): 1427–34. doi:10.1001/jama.287.11.1427. PMID 11903030. Free full text with registration
Neurotransmitter metabolic intermediates
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catecholamines |
Anabolism
(tyrosine→epinephrine) |
- Tyrosine → Levodopa → Dopamine → Norepinephrine → Epinephrine
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Catabolism/
metabolites |
dopamine: |
- DOPAL
- DOPAC
- MOPET
- Hydroxytyrosol
- 3-Methoxytyramine
- Homovanillic acid
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norepinephrine: |
- 3,4-Dihydroxymandelic acid
- Normetanephrine
- Vanillylmandelic acid
- 3-Methoxy-4-hydroxyphenylglycol
- Dihydroxyphenylethylene glycol
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epinephrine: |
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tryptophan→serotonin |
anabolism: |
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catabolism: |
- 5-Hydroxyindoleacetic acid
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serotonin→melatonin |
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Index of the central nervous system
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Description |
- Anatomy
- meninges
- cortex
- association fibers
- commissural fibers
- lateral ventricles
- basal ganglia
- diencephalon
- mesencephalon
- pons
- cerebellum
- medulla
- spinal cord
- Physiology
- Development
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Disease |
- Cerebral palsy
- Meningitis
- Demyelinating diseases
- Seizures and epilepsy
- Headache
- Stroke
- Sleep
- Congenital
- Injury
- Neoplasms and cancer
- Other
- Symptoms and signs
- head and neck
- eponymous
- lesions
- Tests
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Treatment |
- Procedures
- Drugs
- general anesthetics
- analgesics
- addiction
- epilepsy
- cholinergics
- migraine
- Parkinson's
- vertigo
- other
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UpToDate Contents
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English Journal
- A ten-year clinical update of a large ret p.gly533cys kindred with medullary thyroid carcinoma emphasizes the need for an individualized assessment of affected relatives.
- Signorini PS, França MI, Camacho CP, Lindsey SC, Valente FO, Kasamatsu TS, Machado AL, Salim CP, Delcelo R, Hoff AO, Cerutti JM, Dias da Silva MR, Maciel RM.SourceLaboratory of Molecular and Translational Endocrinology, Departments of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, 04039-032, Brazil.
- Clinical endocrinology.Clin Endocrinol (Oxf).2013 Jun 8. doi: 10.1111/cen.12264. [Epub ahead of print]
- OBJECTIVE: Reviewing the clinical outcomes of a large kindred with a RET p.Gly533Cys mutation, 10 years after the first description of this kindred, has provided an important set of clinical data for health care decision making.DESIGN AND PATIENTS: We identified 728 RET533 Brazilian relatives, sprea
- PMID 23745650
- An unusual presentation of MEN2A.
- Casey R, Bell M, Keane M, Smyth A.SourceDepartment of Medicine, University Hospital Galway, Galway, Ireland.
- BMJ case reports.BMJ Case Rep.2013 Jun 6;2013. pii: bcr2012007171. doi: 10.1136/bcr-2012-007171.
- A 35-year-old woman presented with non-specific symptoms of fatigue and weight loss. Radiological investigations diagnosed a metastatic process and large bilateral adrenal masses. Histology from a liver biopsy and skin biopsy confirmed a diagnosis of metastatic medullary thyroid cancer. Further bioc
- PMID 23749818
- Metastatic paraganglioma presenting as a primary shoulder mass.
- Rekhi B, Verma A, Gulia A, Kumar R, Dhanda S, Jambhekar NA.SourceDepartment of Pathology, Tata Memorial Hospital, Dr E.B. Road, Parel, Mumbai, India, 400012, rekhi.bharat@gmail.com.
- Skeletal radiology.Skeletal Radiol.2013 May 31. [Epub ahead of print]
- Paragangliomas uncommonly metastasize, including to the bones, wherein these tumors are designated as malignant paragangliomas. A 56-year-old man presented with pain and immobility in his right arm for 1 year. He had a history of controlled hypertension and diabetes mellitus for 2 years. He had al
- PMID 23722292
Japanese Journal
- Diagnostic accuracy of plasma free metanephrines in a seated position compared with 24-hour urinary metanephrines in the investigation of pheochromocytoma
- Kim Hye Jeong,Lee Ji In,Cho Yoon Young,Lee Soo Youn,Kim Jung Han,Jung Byong Chang,Kim Sun Wook,Chung Jae Hoon,Min Yong-Ki,Lee Myung-Shik,Lee Moon-Kyu,Kim Jae Hyeon
- Endocrine Journal 62(3), 243-250, 2015
- … Plasma-free metanephrines were measured by LC-MS/MS. The cut-off values with optimal sensitivity and specificity for plasma metanephrine and plasma normetanephrine were 0.33 nmol/L and 0.61 nmol/L, respectively. …
- NAID 130005060858
- Diagnostic accuracy of plasma free metanephrines in a seated position compared with 24-hour urinary metanephrines in the investigation of pheochromocytoma
- Kim Hye Jeong,Lee Ji In,Cho Yoon Young,Lee Soo Youn,Kim Jung Han,Jung Byong Chang,Kim Sun Wook,Chung Jae Hoon,Min Yong-Ki,Lee Myung-Shik,Lee Moon-Kyu,Kim Jae Hyeon
- Endocrine Journal, 2014
- … Plasma-free metanephrines were measured by LC-MS/MS. The cut-off values with optimal sensitivity and specificity for plasma metanephrine and plasma normetanephrine were 0.33 nmol/L and 0.61 nmol/L, respectively. …
- NAID 130004704368
- 術前後で持続血糖モニター(CGM)を比較しえたアドレナリン優位褐色細胞腫の1例
- 近藤 剛史,黒田 暁生,曽我部 公子,大黒 由加里,倉橋 清衛,田蒔 基行,木内 美瑞穂,吉田 守美子,安藝 菜奈子,遠藤 逸朗,粟飯原 賢一,藤中 雄一,松久 宗英,松本 俊夫
- 糖尿病 57(9), 729-735, 2014
- 症例は78歳女性.2012年1月,25 mm大の左副腎腫瘍,尿メタネフリン高値,MIBGシンチからアドレナリン優位型褐色細胞腫と診断され,5月当科を紹介された.罹病期間9年の糖尿病があり内服加療をうけるも2010年頃よりHbA1cは悪化し,初診時8.5 %で,褐色細胞腫の周術期管理および血糖管理目的で当科入院した.入院後速やかにインスリン導入を行い,目標血糖値に達した際の持続血糖モニター(以下CG …
- NAID 130004696304
Related Links
- Also known as: Metanephrine and Normetanephrine Formal name: Urine Metanephrines, Total and Fractionated Related tests: Catecholamines, Plasma Free Metanephrines, VMA All content on Lab Tests Online has been . At a ...
- Urine metanephrines testing is used to help detect or rule out the presence of a rare tumor called a pheochromocytoma or a paraganglioma that releases excess metanephrines. ... Normal urine levels of metanephrine ...
Related Pictures
★リンクテーブル★
[★]
- 英
- metanephrine, MN
- 関
- バニリルマンデル酸 VMA。ノルメタネフリン、カテコラミン
- カテコラミンの中間代謝産物の一つ。
- メタネフリンとノルメタネフリン
- LAB
- メタネフリン:40-200μg/日
- ノルメタネフリン:70-300μg/日
- 1mg/日以上で褐色細胞腫、交感神経芽腫、交感神経節細胞腫を疑う(検査の本)。
- 正常上限の3倍以上(JSH2014.123)