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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/04/23 21:55:09」(JST)

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English Journal

  • The basal forebrain cholinergic system in aging and dementia. Rescuing cholinergic neurons from neurotoxic amyloid-β42 with memantine.
  • Nyakas C, Granic I, Halmy LG, Banerjee P, Luiten PG.SourceNeuropsychopharmacological Research Group of Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary; Department of Molecular Neurobiology, University of Groningen, Groningen, The Netherlands.
  • Behavioural brain research.Behav Brain Res.2011 Aug 10;221(2):594-603. Epub 2010 May 27.
  • The dysfunction and loss of basal forebrain cholinergic neurons and their cortical projections are among the earliest pathological events in the pathogenesis of Alzheimer's disease (AD). The evidence pointing to cholinergic impairments come from studies that report a decline in the activity of choli
  • PMID 20553766
  • Effects of long-term memantine on memory and neuropathology in Ts65Dn mice, a model for Down syndrome.
  • Lockrow J, Boger H, Bimonte-Nelson H, Granholm AC.SourceDepartment of Neuroscience, Center on Aging, Medical University of South Carolina, 173 Ashley Avenue, Ste 410D, Charleston, SC 29425, USA.
  • Behavioural brain research.Behav Brain Res.2011 Aug 10;221(2):610-22. Epub 2010 Apr 2.
  • Memantine is a partial NMDA receptor antagonist that has been shown to improve learning and memory in several animal models, and is approved for the treatment of Alzheimer's disease (AD). Chronic treatments using memantine in animal models of Alzheimer's disease show disease-modifying effects and su
  • PMID 20363261

Japanese Journal

  • 新規NMDA受容体拮抗剤であるメマンチン塩酸塩の中等度から高度アルツハイマー型認知症に対する第3相試験--有効性および安全性の検討
  • 中村 祐,本間 昭,北村 伸 [他]
  • 老年精神医学雑誌 22(4), 464-473, 2011-04
  • NAID 40018785832
  • 新規NMDA受容体拮抗剤であるメマンチン塩酸塩の中等度から高度アルツハイマー型認知症に対する後期第2相試験--有効性・安全性および推奨用量の検討
  • 北村 伸,本間 昭,中村 祐 [他]
  • 老年精神医学雑誌 22(4), 453-463, 2011-04
  • NAID 40018785831

Related Links

Before taking this medicine You should not use memantine if you are allergic to it. To make sure memantine is safe for you, tell your doctor if you have: epilepsy or other seizure disorder; liver disease; kidney disease; urination ...
Memantine is an oral N-methyl-D-aspartate glutamate receptor antagonist used in the therapy of Alzheimer disease and dementia. Memantine is associated with a minimal rate of serum enzyme elevations during therapy and has only ...
Easy-to-read patient leaflet for Memantine Tablets. Includes indications, proper use, special instructions, precautions, and possible side effects. ... provides accurate and independent information on more than ...

Related Pictures

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拡張検索memantine hydrochloride



メマンチン塩酸塩塩酸メマンチン memantine hydrochloride
  • NMDA受容体拮抗薬。
  • NMDA受容体は大脳皮質や海馬に高密度に存在し、記憶に関係する長期増強や発達か蘇生においてちゅうしんてきにな役割を担う。ADではシナプス間隙のグルタミン酸濃度が持続的に上昇し、シナプティックノイズが上昇し、記憶を形成する神経伝達シグナルが隠されるため、記憶・学習機能が障害される。まtあ、AβがNMDA受容体のグルタミン三人式部医に結合して細胞内にCa2+が過剰に流入して神経細胞が障害されるとも言われている。(週刊 医学会新聞 2011/5/23)

memantine hydrochloride」

  [★] 塩酸メマンチンメマンチン塩酸塩