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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/12/19 22:47:47」(JST)

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Loxoprofen (INN) is a non-steroidal anti-inflammatory drug in the propionic acid derivatives group, which also includes ibuprofen and naproxen among others. It is marketed in Brazil, Mexico and Japan by Sankyo as its sodium salt, loxoprofen sodium, under the trade name Loxonin, Argentina as Oxeno and in India as Loxomac. It is available in these countries for oral administration, and a transdermal preparation was approved for sale in Japan on January 2006.^[1]

Pharmacokinetics[edit]

Loxoprofen is a prodrug. It is quickly converted to its active trans-alcohol metabolite following oral administration, and reaches its peak plasma concentration within 30 to 50 minutes.

Mechanism of action[edit]

As most NSAIDs, loxoprofen is a non-selective cyclooxygenase inhibitor, and works by reducing the synthesis of prostaglandins from arachidonic acid.

Interactions[edit]

Loxoprofen should not be administered at the same time as second-generation quinolone antibiotics such as ciprofloxacin and norfloxacin, as it increases their inhibition of GABA and this may cause seizures.^[2] It may also increase the plasma concentration of warfarin, methotrexate, sulfonylurea derivatives and lithium salts, so care should be taken when loxoprofen is administered to patients taking any of these drugs.^[2]

References[edit]

^ Daiichi Sankyo Co. (January 24, 2006). "Percutaneous Absorption-Type Analgesic and Anti-inflammatory Drug Loxonin Poultice 100mg Receives Approval for Manufacture" (Press release). Doctor's Guide Global Edition. Retrieved 2007-04-19.
^ ^a ^b (Portuguese) "LOXONIN - Bula do Medicamento [Label Information]". Centralx. 2007. Retrieved 2007-04-19.

Wikimedia Commons has media related to Loxoprofen.

English Journal

Aggravation by paroxetine, a selective serotonin reuptake inhibitor, of antral lesions generated by nonsteroidal anti-inflammatory drugs in rats.

Takeuchi K, Tanaka A, Nukui K, Kojo A, Gyenge M, Amagase K.SourceDivision of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto 607-8414, Japan. takeuchi@mb.kyoto-phu.ac.jp.
The Journal of pharmacology and experimental therapeutics.J Pharmacol Exp Ther.2011 Sep;338(3):850-9. Epub 2011 Jun 24.
Recent clinical studies have suggested a risk of adverse gastric reactions from the concomitant use of selective serotonin (5-HT) reuptake inhibitors (SSRIs) with nonsteroidal anti-inflammatory drugs (NSAIDs). We examined the adverse effects of SSRIs on antral lesions produced by indomethacin in rat
PMID 21705613

Cyclooxygenase inhibitor improved an exudative lesion of choroidal neovascularization in age-related macular degeneration.

Suzuki M, Suzuki T, Nagano A, Hirasawa M, Sakuyama K, Mizuki N.SourceDepartment of Ophthalmology and Visual Sciences, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa - Japan.
European journal of ophthalmology.Eur J Ophthalmol.2011 Jul 25. pii: 222F7EA3-2753-4AE6-9729-75DD0B5AF381. doi: 10.5301/ejo.5000032. [Epub ahead of print]
Purpose. To report a case in which a nonselective cyclooxygenase (COX) inhibitor improved an exudative lesion in age-related macular degeneration. Methods/Results. A 64-year-old man had a complaint of metamorphopsia in the left eye. Visual acuity was 0.5 in the left eye. Fluorescein angiography and
PMID 21928264

Japanese Journal

腸閉塞で発症したNSAIDs潰瘍の1例

河島秀昭,樫山基矢,関川小百合,鹿野哲
日本大腸肛門病学会雑誌 64(4), 230-234, 2011-04-01
… 患者は38歳女性．主訴は腹痛，嘔吐．既往歴は20歳時に虫垂切除術，帝王切開術を2回受けている．36歳時から関節リウマチを発症しloxoprofenを2年間内服していた．腸閉塞の診断で当院入院となった．小腸造影で完全に閉塞しており腹腔鏡下手術を行った．手術所見は癒着はなく回盲部に一致して単発の輪状狭窄を認め回盲部切除を行った．切除標本では回盲弁上に輪状潰瘍と高度の瘢痕狭窄を認め，口側に浅い地図状の潰 …
NAID 10028113225

腹背部の痛みが肋間神経ブロックで軽減した黄色靱帯骨化症を合併していた1症例

境徹也,澄川耕二
日本ペインクリニック学会誌 advpub(0), 1105100029, 2011
腹背部の痛みを訴えていた黄色靱帯骨化症患者に対し肋間神経ブロックを行い，痛みが軽減した症例を報告する．症例は62歳の女性で，11カ月前，両側腹背部痛が出現した．1カ月前，整形外科で胸椎黄色靱帯骨化症を指摘されたが，脊髄症状はなく手術適応にならなかった．ロキソプロフェンの内服で痛みは軽減しなかったので，当科へ紹介受診となった．初診時の腹背部痛の部位は両側Th11から12領域であった．安静時に痛みはな …
NAID 130000659008

Related Pictures

★リンクテーブル★

リンク元	「ロキソプロフェン」
拡張検索	「loxoprofen sodium hydrate」「loxoprofen sodium」

「ロキソプロフェン」

Loxoprofen
Systematic (IUPAC) name
	(RS)-2-{4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	Red Stripe (Brazil)
Routes	Oral, transdermal
Pharmacokinetic data
Protein binding	97%
Metabolism	Hepatic glucuronidation
Half-life	75 minutes
Excretion	Renal
Identifiers
CAS number	68767-14-6
ATC code	M01AE
PubChem	CID 3965
ChemSpider	3828
UNII	3583H0GZAP
KEGG	D08149
ChEBI	CHEBI:76172
ChEMBL	CHEMBL19299
Chemical data
Formula	C15H18O3
Mol. mass	246.302 g/mol; 304.314 g/mol (sodium salt)
	SMILES O=C2C(Cc1ccc(cc1)C(C(=O)O)C)CCC2;
	InChI InChI=1S/C15H18O3/c1-10(15(17)18)12-7-5-11(6-8-12)9-13-3-2-4-14(13)16/h5-8,10,13H,2-4,9H2,1H3,(H,17,18) ; Key:YMBXTVYHTMGZDW-UHFFFAOYSA-N ;
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