WordNet

utter (an exclamation, noise, etc.); "The students delivered a cry of joy"
carry out or perform; "deliver an attack", "deliver a blow"; "The boxer drove home a solid left" (同)drive_home
throw or hurl from the mound to the batter, as in baseball; "The pitcher delivered the ball" (同)pitch
deliver (a speech, oration, or idea); "The commencement speaker presented a forceful speech that impressed the students" (同)present
save from sins (同)redeem, save
bring to a destination, make a delivery; "our local super market delivers"
the act of delivering or distributing something (as goods or mail); "his reluctant delivery of bad news" (同)bringing
the voluntary transfer of something (title or possession) from one party to another (同)livery, legal transfer
the act of delivering a child (同)obstetrical delivery
the event of giving birth; "she had a difficult delivery"
an electrical phenomenon whereby an electromotive force (EMF) is generated in a closed circuit by a change in the flow of current (同)inductance
the act of bringing about something (especially at an early time); "the induction of an anesthetic state"

PrepTutorEJDIC

(人・場所に)〈手紙・荷物など〉'を'『配達する』,届ける;〈伝言など〉'を'伝える《+『名』+『to』+『名』》 / (…に)〈打撃・攻撃など〉'を'『加える』;〈球〉'を'投げる《+『名』+『to』+『名』》 / 〈意見など〉'を'『述べる』,〈判決など〉'を'申し渡す / (…から)〈人〉'を'『朽う』,解放する《+『名』+『from』+『名』》 / (…に)…'を'引き渡す《+『名』+『to』+『名』》 / 〈子〉'を'分娩(ぶんべん)させる;〈妊婦〉‘に'分娩させる
〈U〉〈C〉(…への)(手紙・荷物などの)『配達』,便;配達品《+『for』+『名』》 / 〈U〉《文》(…からの)釈放,解放《+『from』+『名』》 / 〈U〉〈C〉分娩(ぶんべん),出産 / 〈U〉〈C〉話しぶり,弁舌 / 〈U〉(野球の)投球[ぶり],(テニスなどの)打ち方
《所有・所属》…『の』,…のものである,…に属する・《材料・要素》…『でできた』,から成る・《部分》…『の』[『中の』] ・《数量・単位・種類を表す名詞に付いて》…の・《原因・動機》…『で』,のために(because of) ・《主格関係》…『の』,による,によって・《目的格関係》…『を』,の・《同格関係》…『という』・《関係・関連》…『についての』[『の』],の点で・《抽象名詞などと共に》…の[性質をもつ] ・《『It is』+『形』+『of』+『名』+『to』 doの形で,ofの後の名詞を意味上の主語として》・《分離》…『から』・《起原・出所》…『から』[『の』](out of) ・《『名』+『of』+『a』(『an』)+『名』の形で》…のような・《『名』+『of』+『mine』(『yours, his』など独立所有格)の形で》…の…・《時》(1)《副詞句を作って》…に《形容詞句を作って》…の・《時刻》《米》…前(to,《米》before)
〈C〉《米》募兵 / 〈C〉(聖職・公職などへの)就任,就任式 / 〈U〉〈C〉(…を)引き起こすこと《+『to』+『名』》 / 〈U〉(電気の)誘導 / 〈U〉〈C〉(論理学・数学で)帰納,帰納法
OLD French古[代]フランス語

UpToDate Contents

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1. 陣痛誘発 induction of labor
2. 帝王切開歴がある女性における頸管熟化および陣痛の誘発 cervical ripening and induction of labor in women with a prior cesarean delivery
3. 帝王切開出産後の分娩経路の選択 choosing the route of delivery after cesarean birth
4. 早期分娩および早期産の概要 overview of preterm labor and birth
5. 肩甲難産：リスクがある妊娠における危険因子および出産計画 shoulder dystocia risk factors and planning delivery of at risk pregnancies

English Journal

Iron oxide nanoparticle agglomeration influences dose rates and modulates oxidative stress-mediated dose-response profiles in vitro.

Sharma G, Kodali V, Gaffrey M, Wang W, Minard KR, Karin NJ, Teeguarden JG, Thrall BD.Author information Battelle Memorial Institute , Columbus, OH , USA.AbstractSpontaneous agglomeration of engineered nanoparticles (ENPs) is a common problem in cell culture media which can confound interpretation of in vitro nanotoxicity studies. The authors created stable agglomerates of iron oxide nanoparticles (IONPs) in conventional culture medium, which varied in hydrodynamic size (276 nm-1.5 μm) but were composed of identical primary particles with similar surface potentials and protein coatings. Studies using C10 lung epithelial cells show that the dose rate effects of agglomeration can be substantial, varying by over an order of magnitude difference in cellular dose in some cases. Quantification by magnetic particle detection showed that small agglomerates of carboxylated IONPs induced greater cytotoxicity and redox-regulated gene expression when compared with large agglomerates on an equivalent total cellular IONP mass dose basis, whereas agglomerates of amine-modified IONPs failed to induce cytotoxicity or redox-regulated gene expression despite delivery of similar cellular doses. Dosimetry modelling and experimental measurements reveal that on a delivered surface area basis, large and small agglomerates of carboxylated IONPs have similar inherent potency for the generation of ROS, induction of stress-related genes and eventual cytotoxicity. The results suggest that reactive moieties on the agglomerate surface are more efficient in catalysing cellular ROS production than molecules buried within the agglomerate core. Because of the dynamic, size and density-dependent nature of ENP delivery to cells in vitro, the biological consequences of agglomeration are not discernible from static measures of exposure concentration (μg/ml) alone, highlighting the central importance of integrated physical characterisation and quantitative dosimetry for in vitro studies. The combined experimental and computational approach provides a quantitative framework for evaluating relationships between the biocompatibility of nanoparticles and their physical and chemical characteristics.
Nanotoxicology.Nanotoxicology.2014 Sep;8(6):663-75. doi: 10.3109/17435390.2013.822115. Epub 2013 Jul 31.
Spontaneous agglomeration of engineered nanoparticles (ENPs) is a common problem in cell culture media which can confound interpretation of in vitro nanotoxicity studies. The authors created stable agglomerates of iron oxide nanoparticles (IONPs) in conventional culture medium, which varied in hydro
PMID 23837572

Lysine-based surfactants in nanovesicle formulations: the role of cationic charge position and hydrophobicity in in vitro cytotoxicity and intracellular delivery.

Nogueira DR, del Carmen Morán M, Mitjans M, Pérez L, Ramos D, de Lapuente J, Pilar Vinardell M.Author information Departament de Fisiologia, Facultat de Farmàcia, Universitat de Barcelona , Barcelona , Spain.AbstractUnderstanding nanomaterial interactions within cells is of increasing importance for assessing their toxicity and cellular transport. Here, the authors developed nanovesicles containing bioactive cationic lysine-based amphiphiles and assessed whether these cationic compounds increase the likelihood of intracellular delivery and modulate toxicity. Different cytotoxic responses were found among the formulations, depending on surfactant, cell line and endpoint assayed. The induction of mitochondrial dysfunction, oxidative stress and apoptosis were the general mechanisms underlying cytotoxicity. Fluorescence microscopy analysis demonstrated that nanovesicles were internalised by HeLa cells and evidenced that their ability to release endocytosed materials into cell cytoplasm depends on the structural parameters of amphiphiles. The cationic charge position and hydrophobicity of surfactants determine the nanovesicle interactions within the cell and, thus, the resulting toxicity and intracellular behaviour after cell uptake of the nanomaterial. The insights into some toxicity mechanisms of these new nanomaterials contribute in reducing the uncertainty surrounding their potential health hazards.
Nanotoxicology.Nanotoxicology.2014 Jun;8(4):404-21. doi: 10.3109/17435390.2013.793779. Epub 2013 Apr 26.
Understanding nanomaterial interactions within cells is of increasing importance for assessing their toxicity and cellular transport. Here, the authors developed nanovesicles containing bioactive cationic lysine-based amphiphiles and assessed whether these cationic compounds increase the likelihood
PMID 23560805

Improving protein delivery of fibroblast growth factor-2 from bacterial inclusion bodies used as cell culture substrates.

Seras-Franzoso J1, Peebo K2, García-Fruitós E3, Vázquez E3, Rinas U4, Villaverde A3.Author information 1Institut de Biotecnologia i de Biomedicina, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain; Department de Genètica i de Microbiologia, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Bellaterra, 08193 Barcelona, Spain. Electronic address: Joaquin.Seras@uab.cat.2Competence Centre of Food and Fermentation Technologies, Akadeemia tee 15a, 12618 Tallinn, Estonia.3Institut de Biotecnologia i de Biomedicina, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain; Department de Genètica i de Microbiologia, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Bellaterra, 08193 Barcelona, Spain.4Institute of Technical Chemistry-Life Science, Leibniz University of Hannover, D-30167 Hannover, Germany; Helmholtz Centre for Infection Research, Inhoffenstraße 7, D-38124 Braunschweig, Germany.AbstractBacterial inclusion bodies (IBs) have recently been used to generate biocompatible cell culture interfaces, with diverse effects on cultured cells such as cell adhesion enhancement, stimulation of cell growth or induction of mesenchymal stem cell differentiation. Additionally, novel applications of IBs as sustained protein delivery systems with potential applications in regenerative medicine have been successfully explored. In this scenario, with IBs gaining significance in the biomedical field, the fine tuning of this functional biomaterial is crucial. In this work, the effect of temperature on fibroblast growth factor-2 (FGF-2) IB production and performance has been evaluated. FGF-2 was overexpressed in Escherichia coli at 25 and 37°C, producing IBs with differences in size, particle structure and biological activity. Cell culture topographies made with FGF-2 IBs biofabricated at 25°C showed higher levels of biological activity as well as a looser supramolecular structure, enabling a higher protein release from the particles. In addition, the controlled use of FGF-2 protein particles enabled the generation of functional topographies with multiple biological activities being effective on diverse cell types.
Acta biomaterialia.Acta Biomater.2014 Mar;10(3):1354-9. doi: 10.1016/j.actbio.2013.12.021. Epub 2013 Dec 19.
Bacterial inclusion bodies (IBs) have recently been used to generate biocompatible cell culture interfaces, with diverse effects on cultured cells such as cell adhesion enhancement, stimulation of cell growth or induction of mesenchymal stem cell differentiation. Additionally, novel applications of
PMID 24361427

Japanese Journal

Preclinical Evaluation of MicroRNA-34b/c Delivery for Malignant Pleural Mesothelioma

Ueno Tsuyoshi,Toyooka Shinichi,Fukazawa Takuya,Kubo Takafumi,Soh Junichi,Asano Hiroaki,Muraoka Takayuki,Tanaka Norimitsu,Maki Yuho,Shien Kazuhiko,Furukawa Masashi,Sakaguchi Masakiyo,Yamamoto Hiromasa,Tsukuda Kazunori,Miyoshi Shinichiro
Acta Medica Okayama 68(1), 23-26, 2014-02
… In malignant pleural mesothelioma (MPM), we previously reported that expression of miR-34b and miR-34c (miR-34b/c) was frequently downregulated by methylation in MPM cell lines and primary tumors. … The forced overexpression of miR-34b/c showed significant antitumor effects with the induction of apoptosis in MPM cells. … In this study, we examined the in vivo antitumor effects of miR-34b/c using adenovirus vector on MPM. …
NAID 120005372648

P36 白血病細胞に対するメガヘルツ超音波の抗腫瘍効果(ポスターセッション)

藤里砂,平岡和佳子
ソノケミストリー討論会講演要旨集 (22), 93-94, 2013-10-25
… Recently, ultrasound has been a lot of attention in medical field. … Its widely usage in surgical treatment fields such as high intensity focused ultrasound (HIFU) and drug therapy fields such as drug delivery system (DDS) has become an important issue. … Relationship between cavitation-induced OH radical and cell killing after ultrasound irradiation was investigated in order to evaluate the proper therapeutic effect and the safety of MHz ultrasound. …
NAID 110009732808