inbred MRL lpr mice

近交系MRL-lprマウス、純系MRL-lprマウス

WordNet

1. produced by inbreeding
2. the syllable naming the third (mediant) note of any major scale in solmization
3. the 13th letter of the Roman alphabet (同)m

PrepTutorEJDIC

1. 生まれつきの(inborn) / 近親交配による
2. ミ(全音階の第3音)
3. Mach number / mark[s] / Monsieur
4. mouseの複数形

UpToDate Contents

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• 1. Tools for genetics and genomics: Specially bred and genetically engineered mice
• 2. 肥満の病因 pathogenesis of obesity
• 3. レプチンの生理学 physiology of leptin
• 4. 慢性骨髄性白血病の細胞生物学および分子生物学 cellular and molecular biology of chronic myeloid leukemia
• 5. 全身性エリテマトーデスの疫学および病因 epidemiology and pathogenesis of systemic lupus erythematosus

English Journal

• Cyclic GMP catabolism up-regulation in MRL/lpr lupus-prone mice is associated with organ remodeling.

• Yougbaré I1, Keravis T1, Abusnina A1, Decossas M2, Schall N2, Muller S2, Lugnier C3.
• Biochimica et biophysica acta.Biochim Biophys Acta.2014 Jul;1842(7):916-26. doi: 10.1016/j.bbadis.2014.03.001. Epub 2014 Mar 12.
• Production of high titer of antibodies against nuclear components is a hallmark of systemic lupus erythematosus, an autoimmune disease characterized by the progressive chronic inflammation of multiple joints and organs. Organ damage and dysfunction such as renal failure are typical clinical features
• PMID 24631654

• Endogenous Tim-1 promotes severe systemic autoimmunity and renal disease MRL-Fas(lpr) mice.

• Nozaki Y1, Kitching AR2, Akiba H3, Yagita H3, Kinoshita K4, Funauchi M4, Matsumura I4.
• American journal of physiology. Renal physiology.Am J Physiol Renal Physiol.2014 May 15;306(10):F1210-21. doi: 10.1152/ajprenal.00570.2013. Epub 2014 Mar 12.
• The T-cell immunoglobulin mucin 1, also known as kidney injury molecule-1, modulates CD4+ T-cell responses and is also expressed by damaged proximal tubules within the kidney. Both Th subset imbalance (Th1/Th2/Th17) and regulatory T-cell and B-cell alterations contribute to the pathogenesis of autoi
• PMID 24623145

• Siglec-G deficiency leads to more severe collagen-induced arthritis and earlier onset of lupus-like symptoms in MRL/lpr mice.

• Bökers S1, Urbat A, Daniel C, Amann K, Smith KG, Espéli M, Nitschke L.
• Journal of immunology (Baltimore, Md. : 1950).J Immunol.2014 Apr 1;192(7):2994-3002. doi: 10.4049/jimmunol.1303367. Epub 2014 Mar 5.
• Siglec-G is a member of the sialic acid-binding Ig-like lectin (Siglec) family expressed on all B cells. Siglec-G-deficient mice show a large expansion of the B1 cell compartment, demonstrating the crucial role of Siglec-G as an inhibitory receptor on this cellular subset. Although Siglec-G-deficien
• PMID 24600033

Japanese Journal

• ループスモデルマウスによる皮膚ループスの病態解明

• 古川 福実,吉益 隆,金澤 伸雄
• 日本臨床免疫学会会誌 = Japanese journal of clinical immunology 33(4), 169-173, 2010-08-31
• … の境界部に免疫グロブリンあるいは補体が沈着する（Lupus band test LBT陽性）．しかし，皮疹を自然発症するSLEモデルマウスは少ない．その中で，老齢MRL/nマウスの皮膚病変は，ヒトMCTD（混合性結合織病）の皮疹の所見に酷似し，MRL/lprマウスの皮膚病変はヒトLEに類似している．モデルマウスの研究から，各ストレインにはループス易発症性の遺伝学的背景がまず存在し，その上で …
• NAID 10027753579

Related Links

• What does mice, inbred mrl lpr mean? - Definitions.net

U.S. National Library of Medicine. Mice, Inbred MRL lpr. A mouse substrain that is genetically predisposed to the development of systemic lupus erythematosus-like syndrome, which has been found to be clinically similar to the human disease.

• MGI 5.12 - Inbred Strains: MRL - Mouse Genome Informatics - The ...

Origin: Murphy from crosses started in about 1960 involving a number of standard inbred strains. ... Behavioural differences between MRL and MRL-lpr mice can be detected before the onset of immunological symptoms in the latter congenic ...

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★リンクテーブル★

リンク元	「純系MRL-lprマウス」「近交系MRL-lprマウス」
関連記事	「MR」「inbred」「mi」「M」

「純系MRL-lprマウス」

　　[★]

英

inbred MRL lpr mice

関

近交系MRL-lprマウス

「近交系MRL-lprマウス」

　　[★]

英

inbred MRL lpr mice

関

純系MRL-lprマウス

「MR」

　　[★]

• 磁気共鳴 magnetic resonance
• 僧帽弁閉鎖不全症 mitral regurgitation
• 医薬情報担当者
• 精神遅滞 mental retardation
• 麻疹・風疹混合生ワクチン

「inbred」

　　[★]

• 近交系の、純系の、同系繁殖の、同系交配の

関

clone、inbred line、inbred strain、inbreed、inbreeding、pure line

　 　

「mi」

　　[★]

mi-, mio-

• conb form

• より小さい、より少ない。劣った

• ex.

• miosis 縮瞳

？

MI

　 　

「M」

　　[★] メチオニン methionine