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1. 原発性（本態性）高血圧における薬物療法の選択 choice of drug therapy in primary essential hypertension
2. 高齢者における高血圧、特に収縮期高血圧の治療 treatment of hypertension in the elderly patient particularly isolated systolic hypertension
3. 麻酔後回復室（PACU）における心血管の障害 cardiovascular problems in the post anesthesia care unit pacu
4. 高血圧：誰が治療が必要か？ hypertension who should be treated
5. 成人における高血圧の概要 overview of hypertension in adults

Interaction of PEGylated anti-hypertensive drugs, amlodipine, atenolol and lisinopril with lipid bilayer membrane: A molecular dynamics simulation study.

Yousefpour A1, Modarress H2, Goharpey F3, Amjad-Iranagh S4.
Biochimica et biophysica acta.Biochim Biophys Acta.2015 Aug;1850(8):1687-98. doi: 10.1016/j.bbamem.2015.04.016. Epub 2015 May 8.
The interaction of PEGylated anti-hypertensive drugs, amlodipine, atenolol and lisinopril with lipid bilayer membrane dimyristoylphosphatidylcholine (DMPC) has been studied in nine different simulation systems consisting of 128 lipid molecules and appropriate number of water molecules by molecular d
PMID 25960186

The anti-hypertensive drug reserpine induces neuronal cell death through inhibition of autophagic flux.

Lee KI1, Kim MJ2, Koh H2, Lee JI1, Namkoong S1, Oh WK3, Park J4.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2015 Jul 10;462(4):402-8. doi: 10.1016/j.bbrc.2015.04.145. Epub 2015 May 12.
Reserpine is a well-known medicine for the treatment of hypertension and schizophrenia, but its administration can induce Parkinson's disease (PD)-like symptoms in humans and animals. Reserpine inhibits the vesicular transporter of monoamines and depletes the brain of monoamines such as dopamine. Ho
PMID 25976674

Novel oral formulation approach for poorly water-soluble drug using lipocalin-type prostaglandin D synthase.

Mizoguchi M1, Nakatsuji M2, Inoue H2, Yamaguchi K2, Sakamoto A3, Wada K4, Inui T5.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.Eur J Pharm Sci.2015 Jul 10;74:77-85. doi: 10.1016/j.ejps.2015.04.012. Epub 2015 Apr 20.
Lipocalin-type prostaglandin D synthase (L-PGDS), a member of the lipocalin superfamily, possesses the function of forming complexes together with various small lipophilic molecules. In this study, we chose telmisartan as a model drug due to its pH dependent poor water solubility, and developed and
PMID 25906910

Effects of dietary fish oil on cytochrome P450 3A expression in the liver of SHR/NDmcr-cp (cp/cp) rats, an animal model for metabolic syndrome

Yamazaki Tohru,Ohki Takashi,Taguchi Hiroki,Yamamoto Asami,Okazaki Mari,Sakamoto Takeshi,Mitsumoto Atsushi,Kawashima Yoichi,Kudo Naomi
Fundamental Toxicological Sciences 2(3), 127-135, 2015
… Pathophysiological and nutritional conditions often affect the expression of drug-metabolizing enzymes. … Lower levels of CYP3A2 mRNA and CYP3A activity (testosterone 6β-hydroxylation) were distinctive features in SHR/NDcp compared with their controls (Wistar Kyoto rats (WKY), spontaneously hypertensive rats (SHR), stroke-prone SHR and lean littermates of SHR/NDcp). …
NAID 130005093708

天川和久,荒瀬康司,大本由樹 [他],辻裕之,有元佐多雄,小川恭子,加藤久人,神野豊久,有賀明子
人間ドック (Ningen Dock) 29(5), 702-707, 2015
目的：呼吸機能低下と心血管系疾患の関連は以前より報告があるが，原因の詳細は明らかではない．今回，人間ドック受診者の呼吸機能低下と高血圧の関連について経年的に検討した．方法：1997年に当センターで人間ドックを受診し，高血圧がなく1998年から2006年までに最低1回は人間ドックを再受診した男性2,643例を対象とし，2006年までに高血圧が生じたかどうかを目的変数，1997年の各因子を説明変数とし …
NAID 130005084145

道田誠,今井誠
有機合成化学協会誌 73(3), 266-275, 2015
… A process development research of renin inhibitor 1 for anti-hypertensive drug candidate is described. …
NAID 130005065813