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1. 薬物アレルギー患者へのアプローチ an approach to the patient with drug allergy
2. 抗マラリア剤：概要 antimalarial drugs an overview
3. 成人における薬物中毒への一般的アプローチ general approach to drug poisoning in adults
4. リウマチ性疾患における免疫抑制剤および疾患修飾剤の使用の概要 overview of the use of immunosuppressive and disease modifying drugs in the rheumatic diseases
5. 処方剤の誤用：疫学、予防、同定、およびマネージメント prescription drug misuse epidemiology prevention identification and management

New insights into orthostatic hypotension in multiple system atrophy: a European multicentre cohort study.

Pavy-Le Traon A1, Piedvache A2, Perez-Lloret S3, Calandra-Buonaura G4, Cochen-De Cock V5, Colosimo C6, Cortelli P4, Debs R7, Duerr S8, Fanciulli A8, Foubert-Samier A9, Gerdelat A7, Gurevich T10, Krismer F8, Poewe W11, Tison F9, Tranchant C12, Wenning G13, Rascol O14, Meissner WG9; European MSA Study Group.
Journal of neurology, neurosurgery, and psychiatry.J Neurol Neurosurg Psychiatry.2016 May;87(5):554-61. doi: 10.1136/jnnp-2014-309999. Epub 2015 May 14.
OBJECTIVES: Orthostatic hypotension (OH) is a key feature of multiple system atrophy (MSA), a fatal progressive neurodegenerative disorder associated with autonomic failure, parkinsonism and ataxia. This study aims (1) to determine the clinical spectrum of OH in a large European cohort of patients w
PMID 25977316

CYP267A1 and CYP267B1 from Sorangium cellulosum So ce56 are Highly Versatile Drug Metabolizers.

Kern F1, Khatri Y1, Litzenburger M1, Bernhardt R2.
Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2016 Apr;44(4):495-504. doi: 10.1124/dmd.115.068486. Epub 2016 Feb 3.
The guidelines of the Food and Drug Administration and International Conference on Harmonization have highlighted the importance of drug metabolites in clinical trials. As a result, an authentic source for their production is of great interest, both for their potential application as analytical stan
PMID 26842594

Effects of midodrine and L-NAME on systemic and cerebral hemodynamics during cognitive activation in spinal cord injury and intact controls.

Wecht JM1, Weir JP2, Radulovic M3, Bauman WA3.
Physiological reports.Physiol Rep.2016 Feb;4(3). pii: e12683. doi: 10.14814/phy2.12683.
We previously showed that increases in mean arterial pressure (MAP) following administration of midodrine hydrochloride (MH) and nitro-L-arginine methyl ester (L-NAME) resulted in increased mean cerebral blood flow velocity (MFV) during head-up tilt in hypotensive individuals with spinal cord injury
PMID 26869679