hydroxymethylglutaryl-CoA synthase

ヒドロキシメチルグルタリルCoA合成酵素、ヒドロキシメチルグルタリルCoAシンターゼ

WordNet

1. the 3rd letter of the Roman alphabet (同)c
2. (music) the keynote of the scale of C major
3. a general-purpose programing language closely associated with the UNIX operating system

PrepTutorEJDIC

1. carbonの化学記号
2. cobaltの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/05/18 04:32:23」(JST)

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hydroxymethylglutaryl-CoA synthase
Identifiers
EC number	2.3.3.10
CAS number	9027-44-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a hydroxymethylglutaryl-CoA synthase (EC 2.3.3.10) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + H₂O + acetoacetyl-CoA (S)-3-hydroxy-3-methylglutaryl-CoA + CoA

The 3 substrates of this enzyme are acetyl-CoA, H₂O, and acetoacetyl-CoA, whereas its two products are (S)-3-hydroxy-3-methylglutaryl-CoA and CoA.

This enzyme belongs to the family of transferases, specifically those acyltransferases that convert acyl groups into alkyl groups on transfer. The systematic name of this enzyme class is acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming). Other names in common use include (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase, (CoA-acetylating), 3-hydroxy-3-methylglutaryl CoA synthetase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthetase, 3-hydroxy-3-methylglutaryl-CoA synthase, 3-hydroxy-3-methylglutaryl-coenzyme A synthase, beta-hydroxy-beta-methylglutaryl-CoA synthase, HMG-CoA synthase, acetoacetyl coenzyme A transacetase, hydroxymethylglutaryl coenzyme A synthase, and hydroxymethylglutaryl coenzyme A-condensing enzyme. This enzyme participates in 3 metabolic pathways: synthesis and degradation of ketone bodies, valine, leucine and isoleucine degradation, and butanoate metabolism.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1XPK, 1XPL, 1XPM, and 2P8U.

References

• RUDNEY H (1957). "The biosynthesis of beta-hydroxy-beta-methylglutaric acid". J. Biol. Chem. 227 (1): 363–77. PMID 13449080. 

UpToDate Contents

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• 4. 肝グリコーゲン合成酵素欠損症（糖原病0型） liver glycogen synthase deficiency glycogen storage disease 0
• 5. 先天性および後天性鉄芽球性貧血の原因 causes of congenital and acquired sideroblastic anemias

English Journal

• Diacylglycerol acyltransferase-1 inhibition enhances intestinal fatty acid oxidation and reduces energy intake in rats.

• Schober G, Arnold M, Birtles S, Buckett LK, Pacheco-López G, Turnbull AV, Langhans W, Mansouri A.SourcePhysiology and Behavior Laboratory, Institute of Food, Nutrition, and Health, Swiss Federal Institute of Technology, Zurich, Switzerland. gudrun-schober@ethz.ch
• Journal of lipid research.J Lipid Res.2013 May;54(5):1369-84. doi: 10.1194/jlr.M035154. Epub 2013 Feb 28.
• Acyl CoA:diacylglycerol acyltransferase-1 (DGAT-1) catalyzes the final step in triacylglycerol (TAG) synthesis and is highly expressed in the small intestine. Because DGAT-1 knockout mice are resistant to diet-induced obesity, we investigated the acute effects of intragastric (IG) infusion of a smal
• PMID 23449193

• Overexpression of hydroxymethylglutaryl CoA synthase 2 and 2,4-dienoyl-CoA reductase in rat pancreas following chronic alcohol consumption.

• Satoh M, Haruta-Satoh E, Yamada M, Kado S, Nomura F.SourceClinical Proteomics Research Center, Chiba University Hospital, Chiba University, Chiba, Japan.
• Pancreas.Pancreas.2013 Apr;42(3):475-82. doi: 10.1097/MPA.0b013e318264c8f5.
• OBJECTIVES: The mechanism of alcohol-induced pancreatic damage is unclear. The aim of this study was to clarify the effects of chronic alcohol intake on the pancreatic proteome.METHODS: Rats were fed an alcohol-containing Lieber-DeCarli liquid diet, and the pancreatic proteome was compared with that
• PMID 23486364

• Metabolic profiling of late-term turkey embryos by microarrays.

• de Oliveira JE, Druyan S, Uni Z, Ashwell CM, Ferket PR.SourcePrestage Department of Poultry Science, North Carolina State University, Raleigh, NC, USA.
• Poultry science.Poult Sci.2013 Apr;92(4):1011-28. doi: 10.3382/ps.2012-02354.
• The last stages of embryonic development are crucial for turkeys as their metabolism shifts to accommodate posthatch survival and growth. To better understand the metabolic change that occurs during the perinatal period, focused microarray methodology was used to identify changes in the expression o
• PMID 23472025

Japanese Journal

• Hawthorn Fruit Attenuates Atherosclerosis by Improving the Hypolipidemic and Antioxidant Activities in Apolipoprotein E-Deficient Mice

• Zhang Yuying,Zhang Liang,Geng Yue,Geng Yunhong
• Journal of Atherosclerosis and Thrombosis 21(2), 119-128, 2014
• … The hepatic fatty acid synthase(FAS) and sterol regulatory element binding protein-1c(SREBP-1c) mRNA levels were reduced by 42%(p＜0.05) and 23% p＜0.05) in the mice fed the hawthorn fruit diet compared with that observed in the mice fed a standard diet. … However, the hepatic hydroxymethylglutaryl CoA reductase(HMG-CoAR) mRNA levels showed no significant differences between the two groups. …
• NAID 130004444698

• Effect of Licorice Flavonoid Oil on Cholesterol Metabolism in High Fat Diet Rats

• HONDA Kazuhisa,SANEYASU Takaoki,HASEGAWA Shin [他],TOMINAGA Yuji,YOKOTA Shinichi,KAMISOYAMA Hiroshi
• Bioscience, Biotechnology, and Biochemistry 77(6), 1326-1328, 2013
• … It significantly suppressed hydroxymethylglutaryl-CoA synthase activity and increased cholesterol 7α-hydroxylase activity. …
• NAID 130003361110

• ヒメダカＤＮＡマイクロアレイによる17β-トレンボロンの総合的影響評価

• 村田 里美,門田 克行
• 日本毒性学会学術年会 39.1(0), P-131, 2012
• … 中でも"コレステロール合成"に関与する遺伝子が顕著に誘導され、hydroxymethylglutaryl-CoA synthaseなどを含む15遺伝子が検出された。 …
• NAID 130005008729

Related Links

• hydroxymethylglutaryl coa synthase

Publications, Research Grants, Scientific Experts, Species, Research Topics, Genomes and Genes about hydroxymethylglutaryl coa synthase ... Summary: An enzyme that catalyzes the synthesis of hydroxymethylglutaryl-CoA ...

• HMGCS2 - Hydroxymethylglutaryl-CoA synthase ...

This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. ... « Hide 10 20 30 40 50 MQRLLTPVKR ILQLTRAVQE TSLTPARLLP ...

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★リンクテーブル★

リンク元	「ヒドロキシメチルグルタリルCoA合成酵素」「ヒドロキシメチルグルタリルCoAシンターゼ」
関連記事	「C」「synthase」「CoA」「hydroxymethylglutaryl」「COA」

「ヒドロキシメチルグルタリルCoA合成酵素」

　　[★]

英

hydroxymethylglutaryl-CoA synthase

関

ヒドロキシメチルグルタリルCoAシンターゼ

「ヒドロキシメチルグルタリルCoAシンターゼ」

　　[★]

英

hydroxymethylglutaryl-CoA synthase

関

ヒドロキシメチルグルタリルCoA合成酵素

「C」

　　[★]

• 炭素 carbon
• シトシン cytosine
• システイン cysteine
• シチジン
• セルシウス度 摂氏 degrees Celsius degree C
• 産婦人科領域で「子宮外頚 子宮外頚部 exocervix」を表現するための略語

　 　 　 　

「synthase」

　　[★]

• n.

• (脱離酵素リアーゼの逆反応である合成方向の反応を指す) シンターゼ, 合成酵素, 付加酵素

関

lyase、synthetase、transferase

「CoA」

　　[★]

• 大動脈縮窄症 coactation of the aorta
• 補酵素A coenzyme A

「hydroxymethylglutaryl」

　　[★]

ヒドロキシメチルグルタリル

「COA」

　　[★] 補酵素A coenzyme A CoA