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1. 過敏性腸症候群に対するアロセトロン塩酸塩（Lotronex） alosetron hydrochloride lotronex for irritable bowel syndrome
2. メキシレチンの主な副作用 major side effects of mexiletine
3. 早産児における非経口栄養 parenteral nutrition in premature infants
4. 慢性腎疾患における高リン血症の治療 treatment of hyperphosphatemia in chronic kidney disease
5. 変形性関節症の薬物療法に対する実験的アプローチ investigational approaches to the pharmacologic therapy of osteoarthritis

Acute eosinophilic pneumonia caused by calcium stearate, an additive agent for an oral antihistaminic medication.

Kurai J1, Chikumi H, Kodani M, Sako T, Watanabe M, Miyata M, Makino H, Touge H, Hitsuda Y, Shimizu E.
Internal medicine (Tokyo, Japan).Intern Med.2006;45(17):1011-6. Epub 2006 Oct 2.
A 70-year-old man was admitted to our hospital because of dyspnea after taking an antihistaminic agent (homochlorcyclizine hydrochloride) for itching. Chest roentgenogram showed infiltration in the left lung field, and laboratory data revealed eosinophilia. Examination of the bronchoalveolar lavage
PMID 17016002

Potentiation of L-dopa-induced behavioral excitement by histamine H1-receptor antagonists in mice.

Sato T1, Suemaru K, Matsunaga K, Hamaoka S, Gomita Y, Oishi R.
Japanese journal of pharmacology.Jpn J Pharmacol.1996 May;71(1):81-4.
Effects of histamine H1-receptor antagonists on L-dopa-induced behavioral excitement were examined in mice to confirm behaviorally the inhibition of dopamine uptake by these compounds. L-Dopa (100-300 mg/kg, s.c.) combined with pargyline hydrochloride (80 mg/kg, i.p.) caused a dose-dependent behavio
PMID 8791174

Effect of first-pass metabolism on enantioselective pharmacokinetics after oral administration of (+)-, (-)- and racemic homochlorcyclizine to rats.

Nishikata M1, Nakai A, Fushida H, Miyake K, Arita T, Iseki K, Miyazaki K.
Biological & pharmaceutical bulletin.Biol Pharm Bull.1994 Sep;17(9):1267-71.
The enantioselective relationship between the pharmacokinetics and hepatic metabolism of homochlorcyclizine hydrochloride (HCZ) was investigated using rats. There were no significant differences in blood concentrations between the three forms after intravenous administration (5 mg/kg) of (+)-, (-)-
PMID 7841951

Acute Eosinophilic Pneumonia Caused by CalciumStearate, an Additive Agent for an Oral Antihistaminic Medication

, , , , , , , , ,
Internal Medicine 45(17), 1011-1016, 2006
… A 70-year-old man was admitted to our hospital because of dyspnea after taking an antihistaminic agent (homochlorcyclizine hydrochloride) for itching. … A drug lymphocyte stimulation test was positive only for calcium stearate, an additive contained in the homochlorcyclizine hydrochloride tablet. …
NAID 130000076452

清水千博,花川博義,大槻典男
西日本皮膚科 60(4), 494-497, 1998
64歳の男性に生じた扁平苔癬型薬疹の1例を報告した。躯幹·四肢に生じた痒疹に対し, 塩酸ホモクロルシクリジン(ホモクロミン®), 塩酸エピナスチン(アレジオン®)を内服し, その約1ヵ月後から扁平隆起性紅斑が躯幹·四肢に多発した。その後も内服を続け, 内服2ヵ月後に舞鶴共済病院皮膚科を受診した。主に躯幹·四 …
NAID 130004474443

Potentiation of _L-Dopa-Induced Behavioral Excitement by Histamine H_1-Receptor Antagonists in Mice

, , , , ,
The Japanese journal of pharmacology 71(1), 81-84, 1996-05
… L-Dopa (100-300 mg/kg, s.c.) combined with pargyline hydrochloride (80 mg/kg, i.p.) caused a dose-dependent behavioral excitement. … Tripelennamine (10 mg/kg, s.c.), d-chlorpheniramine (1 and 2 mg/kg, s.c.), homochlorcyclizine (2 and 5 mg/kg, s.c.), diphenhydramine (2 and 5 mg/kg, s.c.) and mepyramine (2 and 5 mg/kg, s.c.) each markedly enhanced the moderate behavioral excitement induced by L-dopa (150 mg/kg) plus pargyline. …
NAID 10008188398