関: homochlorcyclizine hydrochloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/08 15:51:02」(JST)

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Homochlorcyclizine (INN) is an antihistamine which has been marketed in Japan since 1965.^[1] It is used in the treatment of allergies and other conditions. It also has some anticholinergic, antidopaminergic, and antiserotonergic properties.^[2]^[3]

References

^ "Homoclomin Tablets 10 mg" (PDF). Eisai Co. December 2007. Retrieved 2008-07-29. ^{[dead link]}
^ Haraguchi K, Ito K, Kotaki H, Sawada Y, Iga T (June 1997). "Prediction of drug-induced catalepsy based on dopamine D1, D2, and muscarinic acetylcholine receptor occupancies". Drug Metabolism and Disposition: the Biological Fate of Chemicals 25 (6): 675–84. PMID 9193868.
^ KIMURA ET, YOUNG PR, RICHARDS RK (1960). "Pharmacologic properties of N-p-chloro-benzhydryl-N'-methyl homopiperazine dihydrochloride (homochlorcyclizine; SA-97), a serotonin antagonist". The Journal of Allergy 31: 237–47. PMID 14409112.

English Journal

Inhibitory effect of homochlorcyclizine on melanogenesis in α-melanocyte stimulating hormone-stimulated mouse B16 melanoma cells.

Chang TS1, Chen CT.
Archives of pharmacal research.Arch Pharm Res.2012 Jan;35(1):119-27. doi: 10.1007/s12272-012-0113-z. Epub 2012 Feb 2.
The histamine receptor H1 antagonist homochlorcyclizine (HC) has been widely used as an antihistamine agent for the treatment of allergies. However, the effect of HC on skin pigmentation is not known. In the present study, we investigated the inhibitory effect of HC on melanogenesis in mouse B16 mel
PMID 22297750

Acute eosinophilic pneumonia caused by calcium stearate, an additive agent for an oral antihistaminic medication.

Kurai J1, Chikumi H, Kodani M, Sako T, Watanabe M, Miyata M, Makino H, Touge H, Hitsuda Y, Shimizu E.
Internal medicine (Tokyo, Japan).Intern Med.2006;45(17):1011-6. Epub 2006 Oct 2.
A 70-year-old man was admitted to our hospital because of dyspnea after taking an antihistaminic agent (homochlorcyclizine hydrochloride) for itching. Chest roentgenogram showed infiltration in the left lung field, and laboratory data revealed eosinophilia. Examination of the bronchoalveolar lavage
PMID 17016002

Simultaneous determination of ten antihistamine drugs in human plasma using pipette tip solid-phase extraction and gas chromatography/mass spectrometry.

Hasegawa C1, Kumazawa T, Lee XP, Fujishiro M, Kuriki A, Marumo A, Seno H, Sato K.
Rapid communications in mass spectrometry : RCM.Rapid Commun Mass Spectrom.2006;20(4):537-43.
Ten antihistamine drugs, diphenhydramine, orphenadrine, chlorpheniramine, diphenylpyraline, triprolidine, promethazine, homochlorcyclizine, cyproheptadine, cloperastine and clemastine, have been found to be extractable from human plasma samples using MonoTip C18 tips, inside which C18- bonded monoli
PMID 16419026

Japanese Journal

Acute Eosinophilic Pneumonia Caused by CalciumStearate, an Additive Agent for an Oral Antihistaminic Medication

Kurai Jun,Chikumi Hiroki,Kodani Masahiro,Sako Takanori,Watanabe Masanari,Miyata Masanori,Makino Haruhiko,Touge Hirokazu,Hitsuda Yutaka,Shimizu Eiji
Internal Medicine 45(17), 1011-1016, 2006
… A 70-year-old man was admitted to our hospital because of dyspnea after taking an antihistaminic agent (homochlorcyclizine hydrochloride) for itching. … A drug lymphocyte stimulation test was positive only for calcium stearate, an additive contained in the homochlorcyclizine hydrochloride tablet. …
NAID 130000076452

Histamine H_1受容体遮断薬PromethazineおよびHomochlorcyclizineがHaloperidolおよびReduced Haloperidolの定常状態血漿濃度に与える影響について

鈴木昭仁,近藤毅,安井規雄,三原一雄,大谷浩一,古郡華子,長島宇大,兼子直,井上義政
臨床薬理 30(1), 95-96, 1999-01-31
NAID 10011538044

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★リンクテーブル★

リンク元	「ホモクロルシクリジン」
拡張検索	「homochlorcyclizine hydrochloride」

「ホモクロルシクリジン」

Homochlorcyclizine
Systematic (IUPAC) name
	1-[(4-chlorophenyl)-phenylmethyl]-4-methyl-1,4-diazepane
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	℞ (Prescription only);
Routes of; administration	Oral
Identifiers
CAS Number	848-53-3
ATC code	None
PubChem	CID: 3627
ChemSpider	3501
UNII	N5MVC31W2N
KEGG	D08041
ChEMBL	CHEMBL151447
Chemical data
Formula	C19H23ClN2
Molecular mass	314.85 g/mol
	SMILES CN1CCCN(CC1)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl ;