WordNet

be a contributing factor; "make things factor into a companys profitability"
any of the numbers (or symbols) that form a product when multiplied together
an independent variable in statistics
anything that contributes causally to a result; "a number of factors determined the outcome"
consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
a concept whose truth can be proved; "scientific hypotheses are not facts"
a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
of or relating to or constituting the nucleus of an atom; "nuclear physics"; "nuclear fission"; "nuclear forces"
(weapons) deriving destructive energy from the release of atomic energy; "nuclear war"; "nuclear weapons"; "atomic bombs" (同)atomic
constituting or like a nucleus; "annexation of the suburban fringe by the nuclear metropolis"; "the nuclear core of the congregation"
of or relating to or constituting the nucleus of a cell; "nuclear membrane"; "nuclear division"
first in order of importance; "the alpha male in the group of chimpanzees"; "the alpha star in a constellation is the brightest or main star"
the 1st letter of the Greek alphabet
the beginning of a series or sequence; "the Alpha and Omega, the first and the last, the beginning and the end"--Revelations
early testing stage of a software or hardware product; "alpha version"
any high mountain

PrepTutorEJDIC

(…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
『核の』,細胞核の / [『原子』]『核の』
アルファ(ギリシア語アルファベットの第1字A,α;英語のA,aに相当) / アルファ星(星座の主星)
高山,高峰

UpToDate Contents

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1. 糖尿病および遺伝的糖尿病症候群の分類classification of diabetes mellitus and genetic diabetic syndromes [show details]
…sensing and insulin secretion with minimal or no defect in insulin action . Mutations in hepatocyte nuclear factor-1-alpha (HNF1A) and the glucokinase (GCK) gene are most commonly identified, occurring in 52 …
2. ケトーシス傾向のある糖尿病症候群syndromes of ketosis prone diabetes mellitus [show details]
…the genes TCF1, PAX-4, and PDX-1, encoding the key beta cell transcription factors hepatocyte nuclear factor-1-alpha (HNF1a), PAX-4, and pancreas-duodenum homeobox-1 (PDX-1), are enriched in A-b- KPD patients…
3. 肝腺腫hepatic adenoma [show details]
…of hepatic adenoma, three major groupings were identified: those with mutations in hepatocyte nuclear factor 1 alpha (HNF1alpha), those with mutations in beta-catenin, and those with neither mutation and …
4. 乳児期に生じる持続性高インスリン血症性低血糖症の病因、臨床的特徴、診断pathogenesis clinical features and diagnosis of persistent hyperinsulinemic hypoglycemia of infancy [show details]
…CoA dehydrogenase (SCHAD), which interacts with glutamate dehydrogenase; HNF1A gene (hepatocyte nuclear factor 1-alpha) HNF4A gene (hepatocyte nuclear factor 4-alpha) SLC16A1 gene (solute carrier family …
5. 上皮性の卵巣癌、卵管癌、および腹膜癌：病理epithelial carcinoma of the ovary fallopian tube and peritoneum histopathology [show details]

English Journal

Mutations in HNF1A Result in Marked Alterations of Plasma Glycan Profile.

Thanabalasingham G, Huffman JE, Kattla JJ, Novokmet M, Rudan I, Gloyn AL, Hayward C, Adamczyk B, Reynolds RM, Muzinic A, Hassanali N, Pucic M, Bennett AJ, Essafi A, Polasek O, Mughal SA, Redzic I, Primorac D, Zgaga L, Kolcic I, Hansen T, Gasperikova D, Tjora E, Strachan MW, Nielsen T, Stanik J, Klimes I, Pedersen OB, Njølstad PR, Wild SH, Gyllensten U, Gornik O, Wilson JF, Hastie ND, Campbell H, McCarthy MI, Rudd PM, Owen KR, Lauc G, Wright AF.SourceOxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Oxford, U.K.
Diabetes.Diabetes.2012 Dec 28. [Epub ahead of print]
A recent genome-wide association study identified hepatocyte nuclear factor 1-α (HNF1A) as a key regulator of fucosylation. We hypothesized that loss-of-function HNF1A mutations causal for maturity-onset diabetes of the young (MODY) would display altered fucosylation of N-linked glycans on plasma p
PMID 23274891

Hepatocellular adenoma associated with familial adenomatous polyposis coli.

Inaba K, Sakaguchi T, Kurachi K, Mori H, Tao H, Nakamura T, Takehara Y, Baba S, Maekawa M, Sugimura H, Konno H.SourceKeisuke Inaba, Department of Surgery, Iwata City Hospital, Iwata 438-8500, Japan.
World journal of hepatology.World J Hepatol.2012 Nov 27;4(11):322-6. doi: 10.4254/wjh.v4.i11.322.
Hepatocellular adenoma (HCA) is a benign liver tumor that most frequently occurs in young women using oral contraceptives. We report a rare case of HCA in a 29 years old female with familial adenomatous polyposis (FAP). The first proband was her sister, who underwent a total colectomy and was geneti
PMID 23293720

Apolipoprotein M can discriminate HNF1A-MODY from Type 1 diabetes.

Mughal SA, Park R, Nowak N, Gloyn AL, Karpe F, Matile H, Malecki MT, McCarthy MI, Stoffel M, Owen KR.SourceOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford; NIHR Biomedical Centre, Oxford, UK.
Diabetic medicine : a journal of the British Diabetic Association.Diabet Med.2012 Nov 15. doi: 10.1111/dme.12066. [Epub ahead of print]
AIMS: Missed diagnosis of maturity-onset diabetes of the young (MODY) has led to an interest in biomarkers that enables efficient prioritization of patients for definitive molecular testing. Apolipoprotein M (apoM) was suggested as a biomarker for hepatocyte nuclear factor 1 alpha (HNF1A)-MODY bec
PMID 23157689

Japanese Journal

Diffuse Glomerular Nodular Lesions in Diabetic Pigs Carrying a Dominant-Negative Mutant Hepatocyte Nuclear Factor 1-Alpha, an Inheritant Diabetic Gene in Humans

Hara Satoshi,Umeyama Kazuhiro,Yokoo Takashi,Nagashima Hiroshi,Nagata Michio
PLoS ONE 9(3), e92219, 2014-03
… We have induced severe diabetes in pigs carrying a dominant-negative mutant hepatocyte nuclear factor 1-alpha (HNF1α) P291fsinsC, a maturity-onset diabetes of the young type-3 (MODY3) gene in humans. …
NAID 120005425977

HNF1α及びHNF4αはヒト肝UGT1A6及びUGT1A9 mRNA発現量の個人差に関与する

AUEVIRIYAVIT Sasitorn,FURIHATA Tomomi,MORIMOTO Kaori,KOBAYASHI Kaoru,CHIBA Kan
Drug metabolism and pharmacokinetics 22(5), 391-398, 2007-10-25
NAID 10019806834

The Production of a Diabetic Mouse Using Constructs Encoding Porcine Insulin Promoter-Driven Mutant Human Hepatocyte Nuclear Factor-1.ALPHA.

WATANABE Masahito,UMEYAMA Kazuhiro,KAWANO Hiro-omi,IZUNO Naoko,NAGASHIMA Hiroshi,MIKI Keizaburo
Journal of Reproduction and Development 53(2), 189-200, 2007
… A diabetic mouse model was produced using a mutant human hepatocyte nuclear factor-1α gene (HNF1αP291fsinsC) regulated by the porcine insulin promoter. … The functionality of two different constructs containing HNF1αP291fsinsC, termed PD1 and PD2 (cytomegalovirus enhancer minus and plus), were examined in transgenic mice. …
NAID 130000053950