growth hormone-releasing hormone receptor

成長ホルモン放出ホルモン受容体

WordNet

1. cultivate by growing, often involving improvements by means of agricultural techniques; "The Bordeaux region produces great red wines"; "They produce good ham in Parma"; "We grow wheat here"; "We raise hogs here" (同)raise, farm, produce
2. come to have or undergo a change of (physical features and attributes); "He grew a beard"; "The patient developed abdominal pains"; "I got funny spots all over my body"; "Well-developed breasts" (同)develop, produce, get, acquire
3. become attached by or as if by the process of growth; "The tree trunks had grown together"
4. become larger, greater, or bigger; expand or gain; "The problem grew too large for me"; "Her business grew fast"
5. cause to grow or develop; "He grows vegetables in his backyard"
6. increase in size by natural process; "Corn doesnt grow here"; "In these forests, mushrooms grow under the trees"; "her hair doesnt grow much anymore"
7. (biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level; "he proposed an indicator of osseous development in children" (同)growing, maturation, development, ontogeny, ontogenesis
8. (pathology) an abnormal proliferation of tissue (as in a tumor)
9. a progression from simpler to more complex forms; "the growth of culture"
10. something grown or growing; "a growth of hair"
11. vegetation that has grown; "a growth of trees"; "the only growth was some salt grass"
12. a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
13. the secretion of an endocrine gland that is transmitted by the blood to the tissue on which it has a specific effect (同)endocrine, internal_secretion

PrepTutorEJDIC

1. 『成長する』,育つ,〈植物が〉生える,茂る / (類・量・程などにおいて)『増大する』,大きくなる / 『しだいになる』 / …‘を'成長させる,大きくする,育てる / …から生じる(起こる)
2. 〈U〉(…の)『成長』,発育;『発達』,発展《+『of』+『名』》 / 〈U〉(数・量,重要性・力などの)『増加』,増大,拡張《+『of』+『名』》 / 〈U〉《修飾語[句]を伴って》栽培,生産,…産 / 〈C〉成育した物,(草,木,髪,ひげなどの)生えたもの / 〈C〉腫瘍(しゅよう)
3. =sense organ / 受信装置
4. ホルモン

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/03/25 21:50:01」(JST)

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GHRHR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XDG
Identifiers
Aliases	GHRHR, GHRFR, GRFR, IGHD1B, growth hormone releasing hormone receptor
External IDs	OMIM: 139191 MGI: 95710 HomoloGene: 640 GeneCards: GHRHR
Targeted by Drug
Tesamorelin
Gene ontology Molecular function • G-protein coupled receptor activity • growth factor binding • signal transducer activity • peptide hormone binding • protein binding • growth hormone-releasing hormone receptor activity • transmembrane signaling receptor activity Cellular component • cytoplasm • integral component of membrane • membrane • nuclear matrix • plasma membrane • secretory granule • cell surface • nuclear inner membrane • sarcolemma • nuclear outer membrane Biological process • positive regulation of cAMP biosynthetic process • G-protein coupled receptor signaling pathway • adenylate cyclase-activating G-protein coupled receptor signaling pathway • determination of adult lifespan • positive regulation of cAMP metabolic process • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • response to glucocorticoid • cell maturation • adenohypophysis development • water homeostasis • activation of adenylate cyclase activity • response to estrogen • mammary gland development • response to insulin • positive regulation of circadian sleep/wake cycle, non-REM sleep • cell surface receptor signaling pathway • regulation of insulin-like growth factor receptor signaling pathway • positive regulation of insulin-like growth factor receptor signaling pathway • growth hormone secretion • positive regulation of growth hormone secretion • positive regulation of cell proliferation • positive regulation of multicellular organism growth • cellular response to insulin stimulus • somatotropin secreting cell development • regulation of protein metabolic process • lactation • regulation of intracellular steroid hormone receptor signaling pathway • hormone metabolic process • positive regulation of hormone secretion • cAMP-mediated signaling • cellular response to glucose stimulus • signal transduction • multicellular organismal reproductive process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2692	14602
Ensembl	ENSG00000106128	ENSMUSG00000004654
UniProt	Q02643	P32082
RefSeq (mRNA)	NM_000823 NM_001009824	NM_001003685
RefSeq (protein)	NP_000814	NP_001003685.2 NP_001003685
Location (UCSC)	Chr 7: 30.94 – 30.99 Mb	Chr 6: 55.38 – 55.39 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

The growth-hormone-releasing hormone receptor (GHRHR) is a G-protein-coupled receptor that binds growth hormone-releasing hormone. The GHRHR activates a Gs protein that causes a cascade of cAMP via Adenylate cyclase.

Function

This gene, expressed in the pituitary, encodes a receptor for growth-hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth-hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. Many alternate transcriptional splice variants encoding different isoforms have been described, but only two have been characterized to date.

Ligands

Agonists

• CJC-1295
• Dumorelin
• GHRH (somatorelin)
• Rismorelin
• Sermorelin
• Tesamorelin

Antagonists

• MZ-5-156

References

Further reading

• Gaylinn BD (Apr 1999). "Molecular and cell biology of the growth hormone-releasing hormone receptor". Growth Hormone & IGF Research. 9 Suppl A: 37–44. doi:10.1016/S1096-6374(99)80008-2. PMID 10429879. 
• Lin-Su K, Wajnrajch MP (Dec 2002). "Growth Hormone Releasing Hormone (GHRH) and the GHRH Receptor". Reviews in Endocrine & Metabolic Disorders. 3 (4): 313–23. doi:10.1023/A:1020949507265. PMID 12424433. 
• Mayo KE (Oct 1992). "Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone". Molecular Endocrinology. 6 (10): 1734–44. doi:10.1210/me.6.10.1734. PMID 1333056. 
• Squire J, Zhou A, Hassel BA, Nie H, Silverman RH (Jan 1994). "Localization of the interferon-induced, 2-5A-dependent RNase gene (RNS4) to human chromosome 1q25". Genomics. 19 (1): 174–5. doi:10.1006/geno.1994.1033. PMID 7514564. 
• Hashimoto K, Koga M, Motomura T, Kasayama S, Kouhara H, Ohnishi T, Arita N, Hayakawa T, Sato B, Kishimoto T (Oct 1995). "Identification of alternatively spliced messenger ribonucleic acid encoding truncated growth hormone-releasing hormone receptor in human pituitary adenomas". The Journal of Clinical Endocrinology and Metabolism. 80 (10): 2933–9. doi:10.1210/jc.80.10.2933. PMID 7559877. 
• Tang J, Lagacé G, Castagné J, Collu R (Aug 1995). "Identification of human growth hormone-releasing hormone receptor splicing variants". The Journal of Clinical Endocrinology and Metabolism. 80 (8): 2381–7. doi:10.1210/jc.80.8.2381. PMID 7629234. 
• Gaylinn BD, Harrison JK, Zysk JR, Lyons CE, Lynch KR, Thorner MO (Jan 1993). "Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone". Molecular Endocrinology. 7 (1): 77–84. doi:10.1210/me.7.1.77. PMID 7680413. 
• Gaylinn BD, von Kap-Herr C, Golden WL, Thorner MO (Jan 1994). "Assignment of the human growth hormone-releasing hormone receptor gene (GHRHR) to 7p14 by in situ hybridization". Genomics. 19 (1): 193–5. doi:10.1006/geno.1994.1045. PMID 8188233. 
• Wajnrajch MP, Gertner JM, Harbison MD, Chua SC, Leibel RL (Jan 1996). "Nonsense mutation in the human growth hormone-releasing hormone receptor causes growth failure analogous to the little (lit) mouse". Nature Genetics. 12 (1): 88–90. doi:10.1038/ng0196-88. PMID 8528260. 
• Netchine I, Talon P, Dastot F, Vitaux F, Goossens M, Amselem S (Feb 1998). "Extensive phenotypic analysis of a family with growth hormone (GH) deficiency caused by a mutation in the GH-releasing hormone receptor gene". The Journal of Clinical Endocrinology and Metabolism. 83 (2): 432–6. doi:10.1210/jc.83.2.432. PMID 9467553. 
• Petersenn S, Rasch AC, Heyens M, Schulte HM (Feb 1998). "Structure and regulation of the human growth hormone-releasing hormone receptor gene". Molecular Endocrinology. 12 (2): 233–47. doi:10.1210/me.12.2.233. PMID 9482665. 
• Maheshwari HG, Silverman BL, Dupuis J, Baumann G (Nov 1998). "Phenotype and genetic analysis of a syndrome caused by an inactivating mutation in the growth hormone-releasing hormone receptor: Dwarfism of Sindh". The Journal of Clinical Endocrinology and Metabolism. 83 (11): 4065–74. doi:10.1210/jc.83.11.4065. PMID 9814493. 
• Salvatori R, Hayashida CY, Aguiar-Oliveira MH, Phillips JA, Souza AH, Gondo RG, Toledo SP, Conceicão MM, Prince M, Maheshwari HG, Baumann G, Levine MA (Mar 1999). "Familial dwarfism due to a novel mutation of the growth hormone-releasing hormone receptor gene". The Journal of Clinical Endocrinology and Metabolism. 84 (3): 917–23. doi:10.1210/jc.84.3.917. PMID 10084571. 
• Morel G, Gallego R, Boulanger L, Pintos E, Garcia-Caballero T, Gaudreau P (Aug 1999). "Restricted presence of the growth hormone-releasing hormone receptor to somatotropes in rat and human pituitaries". Neuroendocrinology. 70 (2): 128–36. doi:10.1159/000054467. PMID 10461027. 
• Rekasi Z, Czompoly T, Schally AV, Halmos G (Sep 2000). "Isolation and sequencing of cDNAs for splice variants of growth hormone-releasing hormone receptors from human cancers". Proceedings of the National Academy of Sciences of the United States of America. 97 (19): 10561–6. doi:10.1073/pnas.180313297. PMC 27064. PMID 10962031. 
• Salvatori R, Fan X, Phillips JA, Espigares-Martin R, Martin De Lara I, Freeman KL, Plotnick L, Al-Ashwal A, Levine MA (Jan 2001). "Three new mutations in the gene for the growth hormone (gh)-releasing hormone receptor in familial isolated gh deficiency type ib". The Journal of Clinical Endocrinology and Metabolism. 86 (1): 273–9. doi:10.1210/jc.86.1.273. PMID 11232012. 
• Kiaris H, Schally AV, Busto R, Halmos G, Artavanis-Tsakonas S, Varga JL (Jan 2002). "Expression of a splice variant of the receptor for GHRH in 3T3 fibroblasts activates cell proliferation responses to GHRH analogs". Proceedings of the National Academy of Sciences of the United States of America. 99 (1): 196–200. doi:10.1073/pnas.012590999. PMC 117538. PMID 11773624. 
• Salvatori R, Fan X, Mullis PE, Haile A, Levine MA (Mar 2002). "Decreased expression of the GHRH receptor gene due to a mutation in a Pit-1 binding site". Molecular Endocrinology. 16 (3): 450–8. doi:10.1210/me.16.3.450. PMID 11875102. 
• Plonowski A, Schally AV, Busto R, Krupa M, Varga JL, Halmos G (Jun 2002). "Expression of growth hormone-releasing hormone (GHRH) and splice variants of GHRH receptors in human experimental prostate cancers". Peptides. 23 (6): 1127–33. doi:10.1016/S0196-9781(02)00043-8. PMID 12126741. 

External links

• IUPHAR GPCR Database – GHRH receptor
• somatotropin releasing hormone receptor at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 小児における成長ホルモン欠乏症の診断 diagnosis of growth hormone deficiency in children
• 2. 成長ホルモンの生理学 physiology of growth hormone
• 3. 低身長の原因 causes of short stature
• 4. 先端巨大症の原因および臨床症状 causes and clinical manifestations of acromegaly

English Journal

• Phoenixin participated in regulation of food intake and growth in spotted scat, Scatophagus argus.

• Wang M1, Deng SP1, Chen HP2, Jiang DN1, Tian CX1, Yang W1, Wu TL1, Zhu CH1, Zhang Y3, Li GL4.
• Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.Comp Biochem Physiol B Biochem Mol Biol.2018 Dec;226:36-44. doi: 10.1016/j.cbpb.2018.07.007. Epub 2018 Aug 13.
• PMID 30114526

• Association between the GHR, GHRHR, and IGF1 gene polymorphisms and milk yield and quality traits in Sarda sheep.

• Dettori ML1, Pazzola M2, Paschino P1, Amills M3, Vacca GM1.
• Journal of dairy science.J Dairy Sci.2018 Nov;101(11):9978-9986. doi: 10.3168/jds.2018-14914. Epub 2018 Aug 23.
• PMID 30146276

• Induction of Apoptosis in Pterygium Cells by Antagonists of Growth Hormone-Releasing Hormone Receptors.

• Qin YJ1, Chu WK2, Huang L3,4, Ng CHY5, Chan TCY2, Cao D2, Yang C1, Zhang L1, Huang SP1, Li J1, Lin HL1, Li WQ1, Chen L1, Schally AV6,7, Chan SO8, Zhang HY1, Pang CP2.
• Investigative ophthalmology & visual science.Invest Ophthalmol Vis Sci.2018 Oct 1;59(12):5060-5066. doi: 10.1167/iovs.18-24751.
• PMID 30357400

Japanese Journal

• Progression of Intracranial Meningioma during Luteinizing Hormone-Releasing Hormone Agonist Treatment for Prostate Cancer: Case Report

• , , ,
• Neurologia medico-chirurgica 54(4), 327-330, 2014
• … The authors describe a male patient who developed a large intracranial meningioma during the hormone therapy for pre-existing prostate cancer. … Leuprorelin acetate, a luteinizing hormone-releasing hormone (LH-RH) agonist, was subsequently administered to the patient once a month for 3 years. … Leuprorelin acetate may accelerate the rapid growth of meningioma in this patient. …
• NAID 130003383239

• Interaction of PICK1 with C-Terminus of Growth Hormone-Releasing Hormone Receptor (GHRHR) Modulates Trafficking and Signal Transduction of Human GHRHR

• KATSUSHIMA Yuriko,SATO Takeya,YAMADA Chika,ITO Moe,SUZUKI Yuki,OGAWA Eishin,SUKEGAWA Izumi,SUKEGAWA Jun,FUKUNAGA Kohji,YANAGISAWA Teruyuki
• Journal of pharmacological sciences 122(3), 193-204, 2013-07-20
• NAID 10031185413

• Interaction of PICK1 with C-Terminus of Growth Hormone–Releasing Hormone Receptor (GHRHR) Modulates Trafficking and Signal Transduction of Human GHRHR

• , , [他], , , , , , ,
• Journal of Pharmacological Sciences 122(3), 193-204, 2013
• … Release of growth hormone (GH) from the somatotroph is regulated by binding GH-releasing hormone (GHRH) to its cognate receptor (GHRHR), one of the members of the G protein–coupled receptor (GPCR) superfamily. … Proteins bound to the carboxy (C)-terminus of GPCR have been reported to regulate intracellular trafficking and function of the receptor; …
• NAID 130003362719

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★リンクテーブル★

リンク元	「成長ホルモン放出ホルモン受容体」
関連記事	「grow」「growth」

「成長ホルモン放出ホルモン受容体」

　　[★]

英

growth hormone-releasing hormone receptor GHRH receptor

関

「grow」

　　[★]

• v.

(過去: grew-過去分詞: grown)

• 成長する、生育する、伸びる

関

extend、growth、outgrow、outgrowth、stretch

　 　 　 　 　 　 　

「growth」

　　[★]

• n.

• 成長