WordNet

travel or traverse (a distance); "This car does 150 miles per hour"; "We did 6 miles on our hike every day"
the syllable naming the first (tonic) note of any major scale in solmization (同)doh, ut
proceed or get along; "How is she doing in her new job?"; "How are you making out in graduate school?"; "Hes come a long way" (同)fare, make_out, come, get along
create or design, often in a certain way; "Do my room in blue"; "I did this piece in wood to express my love for the forest" (同)make
carry on or function; "We could do with a little more help around here" (同)manage
get (something) done; "I did my job" (同)perform
treat with an agent; add (an agent) to; "The ray dosed the paint"
the quantity of an active agent (substance or radiation) taken in or absorbed at any one time (同)dosage
a measured portion of medicine taken at any one time (同)dosage
pertaining to or referring to origin; "genetic history reconstructs the origins of a literary work"
of or relating to the science of genetics; "genetic research" (同)genetical
the branch of biology that studies heredity and variation in organisms (同)genetic science
agile Old World viverrine having a spotted coat and long ringed tail (同)Genetta genetta

PrepTutorEJDIC

《疑問文・否定文を作る》 / 《否定命令文を作る》 / 《助動詞とbe動詞のどちらも含まない文に用いて付加疑問を作る》 / 《強意語として》 / 《文》《助動詞とbe動詞のどちらも含まない文に用いて倒置文を作る》 / 《あいづちを打つ場合に》 / 《先行する動詞またはそれを含む述部の代用》 / 《so,nor,neitherで始まる簡略文で》 / …‘を'『する』,行う,果たす / 《通例have done,時にbe doneの形で》…‘を'『終える』,済ませる / …‘を'作る,作り出す / …‘を'『処理する』,整える,片付ける / 〈学課〉‘を'『勉強する』,専攻する / 〈利益・害など〉‘を'与える,もたらす / 〈人〉‘に'『役立つ』,用が足りる(serve) / …の速度で進む,距離を行く / …‘を'見物する / 〈劇〉‘を'上演する;…‘の'役を演じる / …の役目(仕事)をする / 《おもに英》…‘を'だます,かつぐ / 《話》…をへとへとにさせる / 『する』;活動する / 《通例have done,時にbe doneの形で》(…を)『終える』,済ます《+『with』+『名』》 / 〈事が〉『運ぶ』;〈人が〉暮らしていく,健康である / 〈物が〉(…に)『間に合う』,十分である;〈人が〉(…に)役に立つ,向く《+『for』+『名』》 / 《複数形で》すべきこと / 〈C〉《おもに英》大宴会,大パーティー / 〈C〉《英話》詐欺,ぺてん
ド(全音階の第1音)
(おもに飲み薬1回分の)『服用量』 / (痛いこと・いやなことの)1回分,一定量 / (人などが受ける放射線の)線量 / 性病 / (…を)…‘に'投薬する,服用させる《+『名』+『with』+『名』》
遺伝学

UpToDate Contents

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1. 遺伝学：用語集 genetics glossary of terms
2. 分子遺伝学の原理 principles of molecular genetics
3. アルツハイマー病の遺伝学 genetics of alzheimer disease
4. 高血圧の病因における遺伝的要因 genetic factors in the pathogenesis of hypertension
5. 遺伝性乳癌・卵巣癌症候群の遺伝カウンセリングおよび遺伝子検査 genetic counseling and testing for hereditary breast and ovarian cancer

English Journal

BDNF - a key transducer of antidepressant effects.

Björkholm C1, Monteggia LM2.
Neuropharmacology.Neuropharmacology.2016 Mar;102:72-9. doi: 10.1016/j.neuropharm.2015.10.034. Epub 2015 Nov 11.
How do antidepressants elicit an antidepressant response Here, we review accumulating evidence that the neurotrophin brain-derived neurotrophic factor (BDNF) serves as a transducer, acting as the link between the antidepressant drug and the neuroplastic changes that result in the improvement of the
PMID 26519901

Insulin signaling genes modulate nicotine-induced behavioral responses in Caenorhabditis elegans.

Wescott SA1, Ronan EA, Xu XZ.
Behavioural pharmacology.Behav Pharmacol.2016 Feb;27(1):44-9. doi: 10.1097/FBP.0000000000000186.
Insulin signaling has been suggested to modulate nicotine dependence, but the underlying genetic evidence has been lacking. Here, we used the nematode, Caenorhabditis elegans, to investigate whether genetic alterations in the insulin signaling pathway affect behavioral responses to nicotine. For thi
PMID 26317299

Influence of Absorption, Distribution, Metabolism, and Excretion Genomic Variants on Tacrolimus/Sirolimus Blood Levels and Graft-versus-Host Disease after Allogeneic Hematopoietic Cell Transplantation.

Khaled SK1, Palmer JM2, Herzog J3, Stiller T2, Tsai NC2, Senitzer D4, Liu X2, Thomas SH5, Shayani S6, Weitzel J3, Forman SJ5, Nakamura R5.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.Biol Blood Marrow Transplant.2016 Feb;22(2):268-76. doi: 10.1016/j.bbmt.2015.08.027. Epub 2015 Aug 30.
Allelic variants of genes implicated in drug absorption, distribution, metabolism, and excretion (ADME) determine the pharmacokinetic variability of many medications and are increasingly recognized as important factors determining the success or failure of medical treatments. Both tacrolimus and sir
PMID 26325438

Japanese Journal

Altered gene expression profile in ovarian follicle in rats treated with indomethacin and RU486

, , , , , ,
The Journal of Toxicological Sciences 40(3), 413-425, 2015
… To characterize genetic alterations in unruptured follicles, gene expression profiles in ovarian follicle were analyzed in indomethacin- and RU486-treated female Sprague-Dawley rats. … Ovaries are collected at 22:00 on the proestrus day and 10:00 on the following estrus day after a single dose of indomethacin and RU486. … Here, we clarify genetic alterations induced by the inhibition of cyclooxygenase or progesterone receptor. …
NAID 130005068420

バイオマーカーの適格性評価を支えるレギュラトリーサイエンス（オーバービュー）

頭金正博,斎藤嘉朗
薬学雑誌. 乙号 135(5), 649-653, 2015
… Biomarkers include proteins, metabolites, and genetic targets; … In clinical studies, biomarkers are widely used as an index of clinical efficacy and safety for dose-adjustment and for patient selection. …
NAID 130005066926

運動失調はみとめずパーキンソン症状を呈したspinocerebellar ataxia type 6（SCA6）の1例

竹島愼一,竹田育子,小畠敬太郎,山下徹,阿部康二,栗山勝
臨床神経学 55(4), 243-247, 2015
症例は57歳男性である．50歳で運動緩慢が出現し，抗パーキンソン病薬を投与し，レボドパ最高800 mgの投与をおこなった．反応はあるが，感受性は悪く，満足ある効果はなかった．脳MRIで小脳虫部と半球の萎縮，脳SPECTで両側頭頂葉血流低下，心筋シンチグラフィーで集積低下，DATスキャンで線条体への左右差のある中等度集積低下をみとめた．母親は純粋型小脳失調を示し，パーキンソン症状はなった．母親の同胞 …
NAID 130005066232