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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/02/22 06:58:20」(JST)

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Gabexate is a serine protease inhibitor which is used therapeutically (as gabexate mesilate) in the treatment of pancreatitis, disseminated intravascular coagulation,^[1] and as a regional anticoagulant for haemodialysis.^[2]

References

^ Yuksel M, Okajima K, Uchiba M, Okabe H (2003). "Gabexate mesilate, a synthetic protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production by inhibiting activation of both nuclear factor-kappaB and activator protein-1 in human monocytes". J. Pharmacol. Exp. Ther. 305 (1): 298–305. doi:10.1124/jpet.102.041988. PMID 12649382. http://jpet.aspetjournals.org/cgi/reprint/305/1/298.pdf.
^ Cavallini G, Tittobello A, Frulloni L, Masci E, Mariana A, Di Francesco V (1996). "Gabexate for the prevention of pancreatic damage related to endoscopic retrograde cholangiopancreatography. Gabexate in digestive endoscopy--Italian Group". N. Engl. J. Med. 335 (13): 919–23. doi:10.1056/NEJM199609263351302. PMID 8786777. http://content.nejm.org/cgi/reprint/335/13/919.pdf.

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1. 急性膵炎の治療 treatment of acute pancreatitis
2. ERCP後膵炎 post ercp pancreatitis

English Journal

Multidrug strategies are effective in the treatment of severe experimental pancreatitis.

Werner J, Hartwig W, Hackert T, Kaiser H, Schmidt J, Gebhard MM, Büchler MW, Klar E.SourceDepartment of General Surgery, University of Heidelberg, Heidelberg, Germany.
Surgery.Surgery.2012 Mar;151(3):372-81. Epub 2011 Oct 6.
BACKGROUND: Trypsinogen activation, oxygen radicals, cytokines, leukocyte infiltration, and pancreatic ischemia are important steps in the pathogenesis of necrotizing pancreatitis and associated systemic complications. Several drugs that inhibit those pathogenetic steps attenuated biochemical and hi
PMID 21982067

Life-threatening acute acalculous cholecystitis in a patient with renal cell carcinoma treated by sunitinib: a case report.

Nakano K, Suzuki K, Morita T.AbstractABSTRACT:
Journal of medical case reports.J Med Case Reports.2012 Feb 20;6(1):69. [Epub ahead of print]
ABSTRACT:INTRODUCTION: Sunitinib, an oral multitargeted tyrosine kinase inhibitor, is widely used in the treatment of renal cell carcinoma and gastrointestinal stromal tumor and has had a variety of adverse events. However, sunitinib-related acute cholecystitis has been reported in only two patients
PMID 22348690

Japanese Journal

症例メシル酸ガベキサートによるEosinophilic Panniculitisの1例

芦田敦子,大橋敦子,木庭幸子 [他]
皮膚科の臨床 53(12), 1783-1785, 2011-11
NAID 40019058670

Extracorporeal membrane oxygenationにより救命しえた新型インフルエンザによる呼吸不全の1例

仁科雅良/佐藤孝幸/石井真佐隆/須賀弘泰/横山利光/西久保俊士/増田崇光/中川隆雄
東京女子医科大学雑誌 81(5), 377-380, 2011-10-25
今回われわれは、Extracorporeal membrane oxygenation (ECMO) により救命しえた新型インフルエンザによる呼吸不全の1例を経験したので報告する。患者は59歳、男性。咳と発熱が出現した。翌日近医へ入院した。インフルエンザ簡易検査が陰性だったので抗菌薬を投与された。2日後、呼吸状態が悪化した。簡易検査が陽性となったので、ラニナミビルを吸入した。当センターへ紹介・搬送 …
NAID 110008672491

Related Pictures

★リンクテーブル★

リンク元	「ガベキサート」
拡張検索	「gabexate mesilate」

「ガベキサート」

Gabexate
Systematic (IUPAC) name
	ethyl 4-[6-(diaminomethylideneamino)hexanoyloxy]benzoate
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	39492-01-8
ATC code	None
PubChem	CID 3447
ChemSpider	3329
UNII	4V7M9137X9
KEGG	D08004
ChEMBL	CHEMBL87563
Chemical data
Formula	C16H23N3O4
Mol. mass	311.37 g/mol
	SMILES O=C(Oc1ccc(cc1)C(=O)OCC)CCCCC/N=C(\N)N;
	InChI InChI=1S/C16H23N3O4/c1-2-22-15(21)12-7-9-13(10-8-12)23-14(20)6-4-3-5-11-19-16(17)18/h7-10H,2-6,11H2,1H3,(H4,17,18,19); Key:YKGYIDJEEQRWQH-UHFFFAOYSA-N ;
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　　[★]

英: gabexate
化: メシル酸ガベキサート gabexate mesilate ガベキサートメシル酸塩
商: アガリット、エフオーワイ FOY、パナベート、プロビトール、メクロセート、レミナロン
関: DIC

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ガベキサート : 約 10,600 件
ガベキセート : 約 80 件

蛋白分解酵素阻害薬。

「gabexate mesilate」

　　[★] ガベキサート。メシル酸ガベキサート

[pmid12649382-1] Yuksel M, Okajima K, Uchiba M, Okabe H (2003). "Gabexate mesilate, a synthetic protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production by inhibiting activation of both nuclear factor-kappaB and activator protein-1 in human monocytes". J. Pharmacol. Exp. Ther. 305 (1): 298–305. doi:10.1124/jpet.102.041988. PMID 12649382. http://jpet.aspetjournals.org/cgi/reprint/305/1/298.pdf.

[pmid8786777-2] Cavallini G, Tittobello A, Frulloni L, Masci E, Mariana A, Di Francesco V (1996). "Gabexate for the prevention of pancreatic damage related to endoscopic retrograde cholangiopancreatography. Gabexate in digestive endoscopy--Italian Group". N. Engl. J. Med. 335 (13): 919–23. doi:10.1056/NEJM199609263351302. PMID 8786777. http://content.nejm.org/cgi/reprint/335/13/919.pdf.

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gabexate