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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/09/13 20:03:30」(JST)

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English Journal

  • FAM3A is a target gene of peroxisome proliferator-activated receptor gamma.
  • Zhou Y, Jia S, Wang C, Chen Z, Chi Y, Li J, Xu G, Guan Y, Yang J.SourceDepartment of Physiology and Pathophysiology, China.
  • Biochimica et biophysica acta.Biochim Biophys Acta.2013 Aug;1830(8):4160-70. doi: 10.1016/j.bbagen.2013.03.029. Epub 2013 Apr 3.
  • BACKGROUND: To date, the biological function of FAM3A, the first member of FAM3 gene family, remains unknown. We aimed to investigate whether the expression of FAM3A in liver cells is regulated by peroxisome proliferator-activated receptors (PPARs).METHODS AND RESULTS: The transcriptional activity o
  • PMID 23562554
  • Fabrication of fenofibrate nanocrystals by probe sonication method for enhancement of dissolution rate and oral bioavailability.
  • Ige PP, Baria RK, Gattani SG.SourceDepartment of Pharmaceutics and Quality Assurance, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dhule, Maharashtra 425405, India. Electronic address: pradyumna_1978@rediffmail.com.
  • Colloids and surfaces. B, Biointerfaces.Colloids Surf B Biointerfaces.2013 Aug 1;108:366-73. doi: 10.1016/j.colsurfb.2013.02.043. Epub 2013 Mar 23.
  • Fenofibrate (FBT) is lipophillic drug used in hypercholesterolemia and hypertriglyceridemia having logP 5.375, low solubility (practically insoluble in water) and low oral bioavailability (36%). The purpose of work was to develop FBT nanocrystals for the enhancement of solubility and oral bioavailab
  • PMID 23602990

Japanese Journal

  • Cytotoxicity evaluation of symmetrically branched glycerol trimer in human hepatocellular carcinoma HepG2 cells
  • Miyamoto Licht,Watanabe Masashi,Kono Mai [他],MATSUSHITA Tsuyoshi,HATTORI Hatsuhiko,ISHIZAWA Keisuke,NEMOTO Hisao,TSUCHIYA Koichiro
  • Journal of toxicological sciences 37(5), 1059-1063, 2012-10-01
  • NAID 10030876787
  • Hypolipidemic activity of Symplocos cochinchinensis S. Moore leaves in hyperlipidemic rats
  • Sunil Christudas,Ignacimuthu Savarimuthu,Kumarappan Chidambaram
  • Journal of natural medicines 66(1), 32-38, 2012-00-00
  • NAID 40019124879

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Fenofibrate is used to treat high cholesterol and high triglyceride levels. Includes fenofibrate side effects, interactions and indications. ... Generic Name: fenofibrate (FEN oh FYE brate) Brand Name: Antara, Fenoglide, Lipofen, Lofibra ...
Fenofibrate is used with a low-fat diet, exercise, and sometimes with other medications to reduce the amounts of fatty substances such as cholesterol and triglycerides in the blood and to increase the amount of HDL ...

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Fenofibrate Chemical StructureFenofibrate is used along with a non-drug Fenofibratefenofibrate aug 29 2011 fenofibrate is a Generic manufacturer of Fenofibrate Fenofibrate-200mg-10-capsules




  • fibric acidの誘導体(fibric acid derivatves)
  • PPAR activators
  • HDL↑、LDL↓
  • peroxisome proliferator activated receptor(PPAR)を介して薬理作用を発現←転写因子
  • PPARα:肝臓、褐色脂肪細胞で発現。腎臓、心臓、骨格筋でやや発現 (GOO.957)
作用:(1)脂肪酸酸化、LPL合成↑、apoC-III↓ (GOO.957)
apoC-IIIは肝臓分解やレセプターを介した(LDLなどの)取り込みのinhibitorとして機能 (GOO.957)
HDL-Cの増加はapoA-IとApoA-IIの発現を刺激することによる (GOO.957)