WordNet

having an (over)abundance of flesh; "he hadnt remembered how fat she was"
a soft greasy substance occurring in organic tissue and consisting of a mixture of lipids (mostly triglycerides); "pizza has too much fat"
marked by great fruitfulness; "fertile farmland"; "a fat land"; "a productive vineyard"; "rich soil" (同)fertile, productive, rich
lucrative; "a juicy contract"; "a nice fat job" (同)juicy
having a relatively large diameter; "a fat rope"
the 3rd letter of the Roman alphabet (同)c
(music) the keynote of the scale of C major
a general-purpose programing language closely associated with the UNIX operating system
containing or composed of fat; "fatty food"; "fat tissue" (同)fat
any group or radical of the form RCO- where R is an organic group; "an example of the acyl group is the acetyl group" (同)acyl_group

PrepTutorEJDIC

『脂肪』,脂肪分 / (動物の)あぶら身 / (料理用の)油,ヘット / 肥満,太り過ぎ / 『太った』,肥満した / 『脂肪の多い』 / たっぷりとはいった,分厚い / もうかる / (土地が)肥えた / …‘を'太らせる / ふとる,肥える
carbonの化学記号
脂肪質の,脂肪の多い / でぶ,太っちょ
cobaltの化学記号

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 脂質およびプリン代謝障害による代謝性ミオパチー metabolic myopathies caused by disorders of lipid and purine metabolism
2. 先天性代謝異常：分類 inborn errors of metabolism classification
3. 幼児および小児における低血糖症の病因 etiology of hypoglycemia in infants and children
4. ペルオキシソーム病 peroxisomal disorders
5. 先天性代謝異常：代謝性救急疾患 inborn errors of metabolism metabolic emergencies

English Journal

Mitochondrial bioenergetics deregulation caused by long-chain 3-hydroxy fatty acids accumulating in LCHAD and MTP deficiencies in rat brain: A possible role of mPTP opening as a pathomechanism in these disorders?

Tonin AM1, Amaral AU2, Busanello EN2, Gasparotto J2, Gelain DP2, Gregersen N3, Wajner M4.
Biochimica et biophysica acta.Biochim Biophys Acta.2014 Sep;1842(9):1658-67. doi: 10.1016/j.bbadis.2014.06.011. Epub 2014 Jun 16.
Long-chain 3-hydroxylated fatty acids (LCHFA) accumulate in long-chain 3-hydroxy-acyl-CoA dehydrogenase (LCHAD) and mitochondrial trifunctional protein (MTP) deficiencies. Affected patients usually present severe neonatal symptoms involving cardiac and hepatic functions, although long-term neurologi
PMID 24946182

Overproduction of fatty acids in engineered Saccharomyces cerevisiae.

Li X1, Guo D, Cheng Y, Zhu F, Deng Z, Liu T.
Biotechnology and bioengineering.Biotechnol Bioeng.2014 Sep;111(9):1841-52. doi: 10.1002/bit.25239. Epub 2014 Apr 21.
The long hydrocarbon fatty acyl chain is energy rich, making it an ideal precursor for liquid transportation fuels and high-value oleo chemicals. As Saccharomyces cerevisiae has many advantages for industrial production compared to Escherichia coli. Here, we attempted to engineer Saccharomyces cerev
PMID 24752690

Engineering of chromosomal wax ester synthase integrated Saccharomyces cerevisiae mutants for improved biosynthesis of fatty acid ethyl esters.

Shi S1, Valle-Rodríguez JO, Siewers V, Nielsen J.
Biotechnology and bioengineering.Biotechnol Bioeng.2014 Sep;111(9):1740-7. doi: 10.1002/bit.25234. Epub 2014 Apr 18.
In recent years, significant advances have been made to engineer robust microbes for overproducing biochemical products from renewable resources. These accomplishments have to a large extend been based on plasmid based methods. However, plasmid maintenance may cause a metabolic burden on the host ce
PMID 24752598

Japanese Journal

Mutations to the active site of 3-ketoacyl-ACP synthase Ⅲ (FabH) increase polyhydroxyalkanoate biosynthesis in transgenic Escherichia coli

Mueller Alexander P.,Nomura Christopher T.
Journal of bioscience and bioengineering 113(3), 300-306, 2012-03
… Polyhydroxyalkanoate (PHA) production has been enhanced with engineered 3-ketoacyl-ACP synthase III (FabH) enzymes that accept diverse fatty acyl-ACP substrates and convert them to fatty acyl-CoA substrates for polymerization by PHA synthase enzymes resulting in the production of diverse polymers. …
NAID 110009425319

Upregulation of Fatty Acyl-CoA Thioesterases in the Heart and Skeletal Muscle of Rats Fed a High-Fat Diet

, , [他], , , , ,
Biological and Pharmaceutical Bulletin 34(1), 87-91, 2011
… In rodent models of diet-induced obesity, prolonged high-fat feeding increases the cellular uptake of fatty acids and causes lipotoxicity in the heart and skeletal muscle, where substrate overload to beta-oxidation generates mitochondrial stress. … We examined the hypothesis that, because of its catalytic properties, acyl-CoA thioesterase (ACOT) would counteract these detrimental situations by modulating intracellular acyl-CoA levels. …
NAID 130000402268

Activation of Morphine Glucuronidation by Fatty Acyl-CoAs and Its Plasticity : A Comparative Study in Humans and Rodents Including Chimeric Mice Carrying Human Liver

, , , , , , , , ,
Drug metabolism and pharmacokinetics 25(3), 262-273, 2010-06-25
… The formation of morphine-3-glucuronide (M-3-G, pharmacologically inactive) and morphine-6-glucuronide (M-6-G, active metabolite) by liver microsomes from humans and rodents, including chimeric mice carrying human liver, was evaluated in the presence of fatty acyl-CoAs. … Medium- to long-chain fatty acyl-CoAs, including oleoyl-CoAs, at a physiologic level (around 15 μM) markedly enhanced M-3-G formation catalyzed by rat liver microsomes. …
NAID 10027582853

Related Pictures

There are three fatty acyl CoA space of the mitochondria, fatty acyl CoA FATTY ACYL-CoA ESTERS Fatty acyl CoA is impermeable to the inner Fatty Acid Activation by Esterification structure of Acyl-CoA fatty acyl coa forming on the forming ec