WordNet

aspirin that is treated to pass through the stomach unaltered and to dissolve in the intestines
put a coat on; cover the surface of; furnish with a surface; "coat the cake with chocolate" (同)surface
cover or provide with a coat
growth of hair or wool or fur covering the body of an animal (同)pelage
an outer garment that has sleeves and covers the body from shoulder down; worn outdoors
form a coat over; "Dirt had coated her face" (同)cake
come on stage
to come or go into; "the boat entered an area of shallow marshes" (同)come_in, get_into, get_in, go_into, go in, move into
become a participant; be involved in; "enter a race"; "enter an agreement"; "enter a drug treatment program"; "enter negotiations" (同)participate
having or dressed in a coat
having a coating; covered with an outer layer or film; often used in combination; "coated paper has a smooth polished coating especially suitable for halftone printing"; "sugar-coated pills"
of or relating to the enteron (同)enteral

PrepTutorEJDIC

『コート』,オーバー,外とう / (男子背広・婦人スーツの)『上着』;(婦人・子供の)長上着 / (動物の)毛,毛皮;(植物の)外被,皮 / 表面をおおうもの;(ペンキ・ニスなどの)塗り;(金属などの)めっき / 〈人〉‘に'上旦を旦せる / 〈ほこりなどが〉〈症など〉'を'『おおう』;(ペンキなどで)〈壁など〉'を'塗る《+『名』+『with』+『名』》
…‘に'『入る』,入り込む / 〈弾丸などが〉…‘を'突き通す,‘に'入り込む(penetrate) / …‘の'『一員となる』,‘に'入る;…‘に'参加する / (…に)〈人〉‘を'入学させる;(競争などに)〈人・動物など〉‘を'参加させる《+『名』+『in』(『for』)+『名』》 / (…に)…‘を'記入する,登録する《+『名』+『in』(『into, on』)+『名』》 / 〈新しい生活・局面など〉‘に'入る / 〈異議など〉‘を'正式に申し出る / 『入る』 / 登場する

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/30 19:17:16」(JST)

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[Wiki en表示]

An enteric coating is a polymer barrier applied on oral medication. This helps by protecting drugs from the pH (i.e. acidity) of the stomach.^[1]

Most enteric coatings work by presenting a surface that is stable at the highly acidic pH found in the stomach, but breaks down rapidly at a less acidic (relatively more basic) pH. For example, they will not dissolve in the gastric acids of the stomach (pH ~3), but they will in the alkaline (pH 7-9) environment present in the small intestine. Materials used for enteric coatings include fatty acids, waxes, shellac, plastics, and plant fibers.

Drugs that have an irritant effect on the stomach, such as aspirin, can be coated with a substance that will dissolve only in the small intestine. Likewise, certain groups of azoles (esomeprazole, omeprazole, pan and all grouped azoles) are acid-activated. For such types of drugs, enteric coating added to the formulation tends to avoid activation in the mouth and esophagus. However, it has been shown that this may lead to incomplete inhibition of platelets.^[2]

Recently, some companies have begun to utilize enteric coatings on fish oil (omega-3 fatty acids) supplements. The coating prevents the fish oil capsules from being digested in the stomach, which has been known to cause a fishy reflux.

Sometimes the abbreviation "EC" is added beside the name of the drug to indicate that it has an enteric coating.

Composition of coatings

Methyl acrylate-methacrylic acid copolymers
Cellulose acetate succinate
Hydroxy propyl methyl cellulose phthalate
hydroxy propyl methyl cellulose acetate succinate (hypromellose acetate succinate)
polyvinyl acetate phthalate (PVAP)
methyl methacrylate-methacrylic acid copolymers
Shellac
Cellulose acetate trimellitate
Sodium alginate
Zein

References

^ http://www.wellnessletter.com/ucberkeley/feature/should-your-aspirin-wear-a-coat/#
^ http://circ.ahajournals.org/content/early/2012/12/04/CIRCULATIONAHA.112.117283.abstract

UpToDate Contents

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1. 非ステロイド性抗炎症剤（NSAIDs）（アスピリンを含む）：胃十二指腸障害の一次予防 nsaids including aspirin primary prevention of gastroduodenal toxicity
2. アスピリンの無効および耐性 nonresponse and resistance to aspirin
3. 胃石 gastric bezoars
4. 心血管疾患の二次および一次予防におけるアスピリンの利益とリスク benefits and risks of aspirin in secondary and primary prevention of cardiovascular disease
5. アスピリン：リウマチ性疾患における作用機序、主な毒性、および使用 aspirin mechanism of action major toxicities and use in rheumatic diseases

English Journal

Multi-laminated metal hydroxide nanocontainers for oral-specific delivery for bioavailability improvement and treatment of inflammatory paw edema in mice.

Kankala RK1, Kuthati Y1, Sie HW1, Shih HY1, Lue SI2, Kankala S3, Jeng CC4, Deng JP5, Weng CF1, Liu CL6, Lee CH7.
Journal of colloid and interface science.J Colloid Interface Sci.2015 Nov 15;458:217-28. doi: 10.1016/j.jcis.2015.07.044. Epub 2015 Jul 21.
Multiple layers of pH-sensitive enteric copolymers were coated over layered double hydroxide (LDH) nanoparticles for controllable drug release and improved solubility of hydrophobic drugs. The nano-sized LDH carriers significantly improved the accessibility of sulfasalazine molecules that have posit
PMID 26225492

BET 1: Which form of aspirin is the fastest to inhibit platelet aggregation in emergency department patients with non-ST segment elevation myocardial infarction?

Morris N1, Rigg K2, Hogg K2.
Emergency medicine journal : EMJ.Emerg Med J.2015 Oct;32(10):823-6. doi: 10.1136/emermed-2015-205240.1.
A short cut review was carried out to establish whether, in patients with suspected acute coronary syndromes presenting to the emergency department, what form of aspirin has the most rapid onset of action. Papers comparing the speed of onset of chewable aspirin, or soluble aspirin or solid aspirin w
PMID 26385700

The effect of feeding on the pharmacokinetic variables of two commercially available formulations of omeprazole.

Sykes BW1, Underwood C1, McGowan CM2, Mills PC1.
Journal of veterinary pharmacology and therapeutics.J Vet Pharmacol Ther.2015 Oct;38(5):500-3. doi: 10.1111/jvp.12210. Epub 2015 Feb 10.
The objectives of this study were to investigate the impact of formulation (enteric coated and buffered) and feeding on pharmacokinetic variables associated with the oral administration of omeprazole in the horse. Six thoroughbred racehorses were studied in a crossover design. Each received 2 g of
PMID 25676888