WordNet

(biochemistry) a drug that can combine with a receptor on a cell to produce a physiological reaction
a muscle that contracts while another relaxes; "when bending the elbow the biceps are the agonist"
someone involved in a contest or battle (as in an agon)
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
a monoamine neurotransmitter found in the brain and essential for the normal functioning of the central nervous system; as a drug (trade names Dopastat and Intropin) it is used to treat shock and hypotension (同)Dopastat, Intropin

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=sense organ / 受信装置

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/04 12:09:32」(JST)

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A dopamine agonist is a compound that activates dopamine receptors in the absence of that receptor's physiological ligand, the neurotransmitter dopamine. Dopamine agonists activate signaling pathways through the dopamine receptor and trimeric G-proteins, ultimately leading to changes in gene transcription.

Uses

Dopamine

Some medical drugs act as dopamine agonists and can treat hypodopaminergic (low dopamine) conditions; they are typically used for treating Parkinson's disease, attention deficit/hyperactivity disorder (in the form of stimulants) and certain pituitary tumors (prolactinoma), and may be useful for restless legs syndrome (RLS). Both Requip (Ropinirole) and Mirapex (Pramipexole) are FDA-approved for the treatment of RLS. There is also an ongoing clinical trial to test the effectiveness of the dopamine agonist Requip (ropinirole) in reversing the symptoms of SSRI-induced sexual dysfunction.^[1] Additionally, a systematic review and meta-analysis concluded that prophylactic treatment with cabergoline reduces the incidence, but not the severity, of ovarian hyperstimulation syndrome (OHSS), without compromising pregnancy outcomes, in females undergoing stimulated cycles of in vitro fertilization (IVF).^[2]

Side-effects

Some of the common side effects of dopamine agonists include:^[3]^[4]

Euphoria
Pericardial effusion
Fibrous thickening of lining that covers some of the internal organs including the heart or the lungs (fibrotic reaction)
Hallucinations
Causing or worsening psychosis
Orthostatic hypotension
Increased orgasmic intensity
Weight loss
Anorexia (symptom)
Nausea and possible vomiting
Insomnia
Unusual tiredness or weakness
Dizziness
Drowsiness
Possible Narcolepsy manifestations (Sleep attacks)^[5]
Lightheadedness
Raynaud's phenomenon (common side effect of ergot derivatives)
Syncope
Twitching, twisting, or other unusual body movements(dyskinesia or dystonia from both Antiparkinson agents & Stimulants for ADHD .e.g. Levodopa or Ritalin)^[6]^[7]
Pathological addiction (gambling, shopping, internet pornography, hyper-sexuality) – specifically D₃-preferring agonists

Examples

Examples of dopamine agonists include:

Partial agonist

Aripiprazole (Partial agonist of the D₂ family receptors - Trade name "Abilify" in the United States; atypical antipsychotic)
Phencyclidine (a.k.a. PCP; partial agonist. Psychoactivity mainly due to NMDA antagonism)
Quinpirole (Partial agonist of the D₂ and D₃ family of receptors)
Salvinorin A (chief active constituent of the psychedelic herb salvia divinorum, the psychoactivity of which is mainly due to Kappa-opioid receptor agonism; partial agonist at the D₂ with an Intrinsic activity of 40-60%, binding affinity of K_i=5-10nM and EC₅₀=50-90nM)^[8]

Agonists of full/unknown efficacy

Apomorphine (Apokyn) (Dopamine Agonist for Parkinson's disease/Restless leg syndrome)
Bromocriptine (Parlodel) (Dopamine Agonist for Parkinson's disease/Restless leg syndrome)
Cabergoline (Dostinex) (Dopamine Agonist for Parkinson's disease/Restless leg syndrome)
Ciladopa (Dopamine Agonist for Parkinson's disease/Restless leg syndrome)
Dihydrexidine (Dopamine Agonist for Parkinson's disease/Restless leg syndrome)
Dinapsoline (Dopamine Agonist for Parkinson's disease/Restless leg syndrome)
Doxanthrine (Dopamine Agonist for Parkinson's disease/Restless leg syndrome)
Epicriptine (Similar to those of Bromocriptine) (Dopamine Agonist for Parkinson's disease/Restless leg syndrome)
Lisuride (Dopamine Agonist for Parkinson's disease/Restless leg syndrome)
Pergolide (Dopamine Agonist for Parkinson's disease/Restless leg syndrome) (Permax) - Removed from the market in the USA March 29, 2007.^[9]
Piribedil (Dopamine Agonist for Parkinson's disease/Restless leg syndrome) (Pronoran and Trivastal)
Pramipexole (Dopamine Agonist for Parkinson's disease/Restless leg syndrome) (Mirapex and Sifrol)
Propylnorapomorphine (Dopamine Agonist for Parkinson's disease/Restless leg syndrome)
Quinagolide (Norprolac) (Dopamine Agonist for Parkinson's disease/Restless leg syndrome)
Ropinirole (Dopamine Agonist for Parkinson's disease/Restless leg syndrome) (Requip)
Rotigotine (Dopamine Agonist for Parkinson's disease/Restless leg syndrome) (Neupro)
Roxindole (Dopamine Agonist for Parkinson's disease/Restless leg syndrome)
Sumanirole (Dopamine Agonist for Parkinson's disease/Restless leg syndrome)

Some, such as fenoldopam, are selective for dopamine receptor D1.^[10]

References

^ Clinical trial number NCT00334048 at ClinicalTrials.gov - "Treating Sexual Dysfunction From SSRI Medication: a Study Comparing Requip CR to Placebo"
^ Youssef MA, van Wely M, Hassan MA; et al. (March 2010). "Can dopamine agonists reduce the incidence and severity of OHSS in IVF/ICSI treatment cycles? A systematic review and meta-analysis". Hum Reprod Update 16 (5): 459–66. doi:10.1093/humupd/dmq006. PMID 20354100.
^ "MedlinePlus Drug Information: Pramipexole (Systemic)". United States National Library of Medicine. Archived from the original on 2006-09-26. Retrieved 2006-09-27.
^ Boyd, Alan (1995). "Bromocriptine and psychosis: A literature review". Psychiatric Quarterly 66 (1): 87–95. doi:10.1007/BF02238717. PMID 7701022. Retrieved 2008-09-06.
^ Yeung EYH, Cavanna AE (2014). "Sleep Attacks in Patients With Parkinson's Disease on Dopaminergic Medications: A Systematic Review". Movement Disorderes Clinical Practice 1 (4): 307–316. doi:10.1002/mdc3.12063.
^ http://www.medscape.com/viewarticle/718544
^ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC315486/
^ Seeman P, Guan HC, Hirbec H (2009). "Dopamine D2High receptors stimulated by phencyclidines, lysergic acid diethylamide, salvinorin A, and modafinil". Synapse 63 (8): 698–704. doi:10.1002/syn.20647. PMID 19391150.
^ FDA Announces Voluntary Withdrawal of Pergolide Products
^ Ng SS, Pang CC (March 2000). "In vivo venodilator action of fenoldopam, a dopamine D(1)-receptor agonist". Br. J. Pharmacol. 129 (5): 853–8. doi:10.1038/sj.bjp.0703119. PMC 1571905. PMID 10696081.

6. Avanzi M, Uber E, Bonfa F. Pathological gambling in two patients on dopamine replacement therapy for Parkinson’s disease. Neurol Sci 2004; 25:98–101[Medline]

External links

Dopamine Agonists at the US National Library of Medicine Medical Subject Headings (MeSH)
http://www.abc.net.au/news/stories/2008/01/22/2143502.htm
http://neuro.psychiatryonline.org/cgi/content/full/19/4/473

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. ドーパミンの腎臓作用 renal actions of dopamine
2. パーキンソン病の薬理学的治療 pharmacologic treatment of parkinson disease
3. 制吐剤の特性 characteristics of antiemetic drugs
4. 女性の不妊症の治療の概要 overview of treatment of female infertility
5. 周産期心筋症：治療および予後 peripartum cardiomyopathy treatment and prognosis

English Journal

Serotonin (2C) receptor regulation of cocaine-induced conditioned place preference and locomotor sensitization.

Craige CP, Unterwald EM.SourceDepartment of Pharmacologyand Center for Substance Abuse Research, Temple University School of Medicine, 3500N, Broad Street, Philadelphia, PA 19140, United States. Electronic address: caryne.craige@temple.edu.
Behavioural brain research.Behav Brain Res.2013 Feb 1;238:206-10. doi: 10.1016/j.bbr.2012.10.034. Epub 2012 Oct 26.
Previous studies have identified an inhibitory regulatory role of the 5-HT(2C) receptor in serotonin and dopamine neurotransmission. As cocaine is known to enhance serotonin and dopamine transmission, the ability of 5-HT(2C) receptors to modulate cocaine-induced behaviors was investigated. Alteratio
PMID 23103406

D(1) receptor agonists reverse the subchronic phencyclidine (PCP)-induced novel object recognition (NOR) deficit in female rats.

Horiguchi M, Hannaway KE, Adelekun AE, Huang M, Jayathilake K, Meltzer HY.SourceDivision of Psychopharmacology, Vanderbilt University Medical Center, Nashville, TN 37212, USA; Division of Psychiatry and Behavioural Sciences, Northwestern University Feinberg School of Medicine, 303 E. Chicago Avenue Ward 12-104, Chicago, IL 60611, USA; Dainippon Sumitomo Pharma Co., Ltd., Osaka 564-0053, Japan.
Behavioural brain research.Behav Brain Res.2013 Feb 1;238:36-43. doi: 10.1016/j.bbr.2012.09.030. Epub 2012 Sep 24.
Development of dopamine (DA) D(1) receptor agonists is a priority to improve cognitive impairment in schizophrenia (CIS). This study examined the dose-response relationship of the selective D(1) agonist, SKF38393 (0.5-40mg/kg), to reverse the deficit in novel object recognition (NOR), an analog of d
PMID 23018127

Japanese Journal

Dopamine D_1 Agonist Facilitates Long‐term Depression Induction by Callosal Low‐frequency Stimulation in Rat Anterior Cingulate Cortex

Sakuragi Sokichi
愛知教育大学研究報告. 自然科学編 60, 63-69, 2011-03-01
… Dopamine is known to play roles in the processing of emotion. … To test whether dopamine has effects on synaptic plasticity in emotion-processing areas, I examined callosally-evoked field potentials in coronal slices of rat anterior cingulate cortex （ACC） when low-frequency stimulation （LFS ）was applied to corpus callosum as a conditioning stimulus. …
NAID 80021880058

Dopamine D2–Receptor Antagonists Ameliorate Indomethacin-Induced Small Intestinal Ulceration in Mice by Activating α7 Nicotinic Acetylcholine Receptors

Yasuda Masashi,Kawahara Ryoji,Hashimura Hiroshi,Yamanaka Naoki,Iimori Maho,Amagase Kikuko,Kato Shinichi,Takeuchi Koji
Journal of Pharmacological Sciences 116(3), 274-282, 2011
… We have reported that nicotine and the specific α7AChR agonist ameliorate indomethacin-induced intestinal lesions in mice by activating α7 nicotinic acetylcholine receptors (α7nAChR). … Dopamine D2–receptor antagonists, such as domperidone and metoclopramide, enhance the release of ACh from vagal efferent nerves. …
NAID 130001014458

Related Pictures

★リンクテーブル★

リンク元	「ドパミン作動薬」「ドーパミン受容体作動薬」
関連記事	「receptor agonist」

「ドパミン作動薬」

Dopamine Receptor agonist
	Drug class
Use	Parkinson's disease, Attention deficit/hyperactivity disorder(ADHD), restless legs syndrome, clinical depression, etc.
Biological target	Dopamine receptors
ATC code	N04
External links
MeSH	D010300

　　[★]

英: dopamine agonist、dopaminergic agonist、dopaminergic agent, dopaminergic drug, dopamine receptor agonist, dopamine receptor stimulant
同: ドパミン作用薬、ドパミン刺激薬、ドパミン受容体作用薬、ドパミン受容体作動薬、ドパミン受容体刺激薬、ドパミンアゴニスト
関: ドパミン

[show details]

ドパミン受容体刺激薬 : 約 19,800 件
ドパミン受容体作動薬 : 約 30,900 件
ドパミン受容体作用薬 : 69 件
ドパミン刺激薬 : 52 件
ドパミン作動薬 : 約 91,100 件
ドパミン作用薬 : 約 10,100 件

ドパミン作動薬：レボドパ、ブロモクリプチン、インスリン、アルギニン、グルカゴン、プロプラノール(QB.D-254)

「ドーパミン受容体作動薬」

　　[★]

英: dopamine receptor agonist
関: ドパミン受容体作動薬、ドパミン受容体刺激薬

「receptor agonist」

　　[★]

受容体刺激薬、受容体作動薬、受容体アゴニスト、レセプターアゴニスト、受容体作用薬、受容体活性化薬、受容体活性化剤

関: agonist、agonistic

[1] Clinical trial number NCT00334048 at ClinicalTrials.gov - "Treating Sexual Dysfunction From SSRI Medication: a Study Comparing Requip CR to Placebo"

[2] Youssef MA, van Wely M, Hassan MA; et al. (March 2010). "Can dopamine agonists reduce the incidence and severity of OHSS in IVF/ICSI treatment cycles? A systematic review and meta-analysis". Hum Reprod Update 16 (5): 459–66. doi:10.1093/humupd/dmq006. PMID 20354100.

[3] "MedlinePlus Drug Information: Pramipexole (Systemic)". United States National Library of Medicine. Archived from the original on 2006-09-26. Retrieved 2006-09-27.

[4] Boyd, Alan (1995). "Bromocriptine and psychosis: A literature review". Psychiatric Quarterly 66 (1): 87–95. doi:10.1007/BF02238717. PMID 7701022. Retrieved 2008-09-06.

[Yeung_2014-5] Yeung EYH, Cavanna AE (2014). "Sleep Attacks in Patients With Parkinson's Disease on Dopaminergic Medications: A Systematic Review". Movement Disorderes Clinical Practice 1 (4): 307–316. doi:10.1002/mdc3.12063.

[6] ttp://www.medscape.com/viewarticle/718544

[7] ttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC315486/

[8] Seeman P, Guan HC, Hirbec H (2009). "Dopamine D2High receptors stimulated by phencyclidines, lysergic acid diethylamide, salvinorin A, and modafinil". Synapse 63 (8): 698–704. doi:10.1002/syn.20647. PMID 19391150.

[9] FDA Announces Voluntary Withdrawal of Pergolide Products

[pmid10696081-10] Ng SS, Pang CC (March 2000). "In vivo venodilator action of fenoldopam, a dopamine D(1)-receptor agonist". Br. J. Pharmacol. 129 (5): 853–8. doi:10.1038/sj.bjp.0703119. PMC 1571905. PMID 10696081.

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案内

案内

dopamine receptor agonist