関: dTTP、thymidine triphosphate、TTP

WordNet

a nucleoside component of DNA; composed of thymine and deoxyribose (同)thymidine

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/03/27 15:09:25」(JST)

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Deoxythymidine triphosphate (dTTP) is one of the four nucleotide triphosphates that are used in the in vivo synthesis of DNA. Unlike the other deoxyribonucleotide triphosphates, thymidine triphosphate does not contain the "deoxy" prefix in its name.^[1] The corresponding ribonucleoside triphosphate is called uridine triphosphate.

It can be used by DNA ligase to create overlapping "sticky ends" so that protruding ends of opened microbial plasmids may be closed up.

References

^ Coghill, Anne M.; Garson, Lorrin R., ed. (2006). The ACS style guide: effective communication of scientific information (3rd ed.). Washington, D.C.: American Chemical Society. p. 244. ISBN 978-0-8412-3999-9.

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English Journal

Regulated incorporation of two different metal ions into programmed sites in a duplex by DNA polymerase catalyzed primer extension.

Funai T1, Nakamura J, Miyazaki Y, Kiriu R, Nakagawa O, Wada S, Ono A, Urata H.
Angewandte Chemie (International ed. in English).Angew Chem Int Ed Engl.2014 Jun 23;53(26):6624-7. doi: 10.1002/anie.201311235. Epub 2014 Apr 9.
Metal-mediated base pairs formed by the coordination of metal ions to natural or artificial bases impart unique chemical and physical properties to nucleic acids and have attracted considerable interest in the field of nanodevices. Ag(I) ions were found to mediate DNA polymerase catalyzed primer ext
PMID 24719384

Molecular cloning and characterization of Brugia malayi thymidylate kinase.

Doharey PK1, Suthar MK1, Verma A1, Kumar V2, Yadav S1, Balaramnavar VM3, Rathaur S4, Saxena AK3, Siddiqi MI2, Saxena JK5.
Acta tropica.Acta Trop.2014 May;133:83-92. doi: 10.1016/j.actatropica.2014.02.003. Epub 2014 Feb 17.
Thymidylate kinase (TMK) is a potential chemotherapeutic target because it is directly involved in the synthesis of deoxythymidine triphosphate, which is an essential component for DNA synthesis. The gene encoding thymidylate kinase of Brugia malayi was amplified by PCR and expressed in Escherichia
PMID 24556140

Single-molecule fluorescence reveals the unwinding stepping mechanism of replicative helicase.

Syed S1, Pandey M2, Patel SS2, Ha T3.
Cell reports.Cell Rep.2014 Mar 27;6(6):1037-45. doi: 10.1016/j.celrep.2014.02.022. Epub 2014 Mar 13.
Bacteriophage T7 gp4 serves as a model protein for replicative helicases that couples deoxythymidine triphosphate (dTTP) hydrolysis to directional movement and DNA strand separation. We employed single-molecule fluorescence resonance energy transfer methods to resolve steps during DNA unwinding by T
PMID 24630993

Japanese Journal

End-Product Regulation and Kinetic Mechanism of Guanosine-Inosine Kinase from Escherichia coli

, , [他],
Bioscience, biotechnology, and biochemistry 64(5), 972-979, 2000-05-23
… In addition to ATP, it was found that deoxyadenosine 5'-triphosphate, UTP, and CTP could serve as phosphate donors. … The phosphate acceptors were guanosine, inosine, deoxyguanosine and xanthosine, but not adenosine, cytidine, uridine, or deoxythymidine. …
NAID 110002680028

Action of a New Mammalian DNA Polymerase Inhibitor, Sulfoquinovosyldiacylglycerol

, , [他], , , , ,
Biological & pharmaceutical bulletin 22(2), 111-116, 1999-02-15
… α or β by KM043 was non-competitive with both the DNA template and the substrate deoxythymidine 5'-triphosphate (dTTP). …
NAID 110003639619

Inhibition of Salvage Synthesis of Nucleic Acid by Adenosine 3', 5'-Cyclic Decylphosphoramidate in Mastocytoma P-815 Cells

SAITO Makoto,NASU Ayako,KATAOKA Shigehiro,YAMAJI Nobuyuki,ICHIKAWA Atsushi
Journal of pharmacobio-dynamics 15(10), 597-604, 1992-10
… Pretreating the cells with compound 1 (20μM, 4h) caused considerable inhibition of the incorporation of [^3H] thymidine ([^3H] TdR) into [^3H] deoxythymidine 5'-triphosphate ([^3H] dTTP) and that of [^<14>C] hypoxanthine into nucleic acid, but not the synthesis of [^<14>C] dTTP from [U-^<14>C] aspartate. …
NAID 110003637474

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★リンクテーブル★

リンク元	「TTP」「チミジン三リン酸」「thymidine triphosphate」「デオキシチミジン三リン酸」
関連記事	「triphosphate」「deoxythymidine」

「TTP」

Thymidine triphosphate
Names
	IUPAC name [(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl (hydroxy-phosphonooxyphosphoryl) hydrogen phosphate
	Other names dTTP, 2'-deoxythymidine triphosphate
Identifiers
CAS Number	365-08-2 =
ChEMBL	ChEMBL363559
ChemSpider	58493 =
IUPHAR/BPS	5505
Jmol interactive 3D	Image
MeSH	thymidine+5'-triphosphate
PubChem	64968
	SMILES CC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O ;
Properties
Chemical formula	C10H17N2O14P3
Molar mass	482.168
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	(what is ?)
	Infobox references