関: deoxythymidine triphosphate、dTTP、TTP

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/10 23:14:46」(JST)

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Deoxythymidine triphosphate (dTTP) is one of the four nucleoside triphosphates that are used in the in vivo synthesis of DNA. Unlike the other deoxyribonucleotide triphosphates, thymidine triphosphate does not contain the "deoxy" prefix in its name.^[1] The corresponding ribonucleoside triphosphate is called uridine triphosphate.

It can be used by DNA ligase to create overlapping "sticky ends" so that protruding ends of opened microbial plasmids may be closed up.

References

^ Coghill, Anne M.; Garson, Lorrin R., ed. (2006). The ACS style guide: effective communication of scientific information (3rd ed.). Washington, D.C.: American Chemical Society. p. 244. ISBN 978-0-8412-3999-9.

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English Journal

Insights into the structure-function relationship of Brugia malayi thymidylate kinase (BmTMK).

Doharey PK1, Singh SK2, Verma P1, Verma A1, Rathaur S3, Saxena JK4.
International journal of biological macromolecules.Int J Biol Macromol.2016 Jul;88:565-71. doi: 10.1016/j.ijbiomac.2016.04.004. Epub 2016 Apr 1.
Lymphatic filariasis is a debilitating disease caused by lymph dwelling nematodal parasites like Wuchereria bancrofti, Brugia malayi and Brugia timori. Thymidylate kinase of B. malayi is a key enzyme in the de novo and salvage pathways for thymidine 5'-triphosphate (dTTP) synthesis. Therefore, B. ma
PMID 27044348

Analysis of the endogenous deoxynucleoside triphosphate pool in HIV positive and negative individuals receiving tenofovir-emtricitabine.

Chen X1, Castillo-Mancilla JR2, Seifert SM1, McAllister K3, Zheng JH1, Bushman LR1, MaWhinney S4, Anderson PL5.
Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2016 Jun 27. pii: AAC.01019-16. [Epub ahead of print]
Tenofovir (TFV) disoproxil fumarate (TDF) and emtricitabine (FTC), two nucleos(t)ide analogs (NA), are coformulated as an anti-HIV combination pill for treatment and pre-exposure prophylaxis (PrEP). TDF/FTC may have effects on the deoxynucleoside triphosphate (dNTP) pool, due to similar structures a
PMID 27353267

Membrane-permeable Triphosphate Prodrugs of Nucleoside Analogues.

Gollnest T1, Dinis de Oliveira T1, Rath A1, Hauber I2, Schols D3, Balzarini J3, Meier C4.
Angewandte Chemie (International ed. in English).Angew Chem Int Ed Engl.2016 Apr 18;55(17):5255-8. doi: 10.1002/anie.201511808. Epub 2016 Mar 23.
The metabolic conversion of nucleoside analogues into their triphosphates often proceeds insufficiently. Rate-limitations can be at the mono-, but also at the di- and triphosphorylation steps. We developed a nucleoside triphosphate (NTP) delivery system (TriPPPro-approach). In this approach, NTPs ar
PMID 27008042

Japanese Journal

Initiation of Genome Instability and Preneoplastic Processes through Loss of Fhit Expression

Saldivar Joshua C.,Miuma Satoshi,Bene Jessica,Hosseini Seyed Ali,Shibata Hidetaka,Sun Jin,Wheeler Linda J.,Mathews Christopher K.,Huebner Kay
PLoS Genetics 8(11), e1003077, 2012-11-29
… The likely mechanism for the role of Fhit in replication fork progression is through regulation of Thymidine kinase 1 expression and thymidine triphosphate pool levels; …
NAID 120005230513

天然物の抗ウイルス活性評価と応用に関する研究

林利光
藥學雜誌 128(1), 61-79, 2008-01-01
… This effect of SDC was exerted via the activation of viral thymidine kinase (HSV-1 TK) and, as a result, an increase in the cellular concentration of the active form of ACV/GCV, i.e., the triphosphate of ACV or GCV. …
NAID 110006533004

Enhancement of Cellular Adenosine Triphosphate Levels in PC12 Cells by Extracellular Adenosine

Fujimori Hiroyuki,Yasuda Masahiro,Pan-Hou Hidemitsu
Biological & pharmaceutical bulletin 25(3), 307-311, 2002-03-01
… To elucidate the biological significance of extracellular adenine compounds, the effects of adenosine (Ado) on cellular levels of adenine compounds, especially adenosine triphosphate (ATP), in PC12 cells were studied. … Ado and inosine but not adenosine 5'-monophosphate, adenosine 5'-diphosphate, ATP, guanosine, cytosine, thymidine, and uridine, significantly enhanced cellular ATP levels in PC12 cells in time- and dose-dependent manners. …
NAID 110003638692

「TTP」

Thymidine triphosphate
Names
	IUPAC name [(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl (hydroxy-phosphonooxyphosphoryl) hydrogen phosphate
	Other names dTTP, 2'-deoxythymidine triphosphate
Identifiers
CAS Number	365-08-2 =
ChEMBL	ChEMBL363559
ChemSpider	58493 =
IUPHAR/BPS	5505
Jmol interactive 3D	Image
MeSH	thymidine+5'-triphosphate
PubChem	64968
	SMILES CC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O ;
Properties
Chemical formula	C10H17N2O14P3
Molar mass	482.168
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	(what is ?)
	Infobox references