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チミジン 5'-三リン酸

一般情報
IUPAC名	チミジン 5'-三リン酸
別名	dTTP
分子式	C₁₀H₁₇N₂O₁₄P₃
分子量	482.168 g/mol
形状
CAS登録番号	[365-08-2]
性質

チミジン三リン酸（チミジンさんリンさん、Thymidine triphosphate）、略号dTTP^[1]は4つのヌクレオチド三リン酸の一つで生体内(In vivo)DNA合成に利用される。またDNAリガーゼによって、細菌性プラスミドの突起端を閉じる際の"sticky ends"を形成する場面に利用される。

脚注

^ TTPはよくある間違いである。Abbreviations and Symbols for Nucleic Acids, Polynucleotides and their Constituents N-1.1

Deoxythymidine triphosphate (dTTP) is one of the four nucleoside triphosphates that are used in the in vivo synthesis of DNA. Unlike the other deoxyribonucleotide triphosphates, thymidine triphosphate does not contain the "deoxy" prefix in its name.^[1] The corresponding ribonucleoside triphosphate is called uridine triphosphate.

It can be used by DNA ligase to create overlapping "sticky ends" so that protruding ends of opened microbial plasmids may be closed up.

References

^ Coghill, Anne M.; Garson, Lorrin R., ed. (2006). The ACS style guide: effective communication of scientific information (3rd ed.). Washington, D.C.: American Chemical Society. p. 244. ISBN 978-0-8412-3999-9.

This genetics article is a stub. You can help Wikipedia by expanding it.

English Journal

Crucial roles of thymidine kinase 1 and deoxyUTPase in incorporating the antineoplastic nucleosides trifluridine and 2'-deoxy-5-fluorouridine into DNA.

Sakamoto K1, Yokogawa T1, Ueno H1, Oguchi K1, Kazuno H1, Ishida K1, Tanaka N1, Osada A1, Yamada Y1, Okabe H1, Matsuo K1.
International journal of oncology.Int J Oncol.2015 Jun;46(6):2327-34. doi: 10.3892/ijo.2015.2974. Epub 2015 Apr 20.
Trifluridine (FTD) and 2'-deoxy-5-fluorouridine (FdUrd), a derivative of 5-fluorouracil (5-FU), are antitumor agents that inhibit thymidylate synthase activity and their nucleotides are incorporated into DNA. However, it is evident that several differences occur in the underlying antitumor mechanism
PMID 25901475

Bacillus halodurans Strain C125 Encodes and Synthesizes Enzymes from Both Known Pathways To Form dUMP Directly from Cytosine Deoxyribonucleotides.

Oehlenschlæger CB1, Løvgreen MN1, Reinauer E2, Lehtinen E3, Pind ML3, Harris P4, Martinussen J2, Willemoës M5.
Applied and environmental microbiology.Appl Environ Microbiol.2015 May 15;81(10):3395-404. doi: 10.1128/AEM.00268-15. Epub 2015 Mar 6.
Analysis of the genome of Bacillus halodurans strain C125 indicated that two pathways leading from a cytosine deoxyribonucleotide to dUMP, used for dTMP synthesis, were encoded by the genome of the bacterium. The genes that were responsible, the comEB gene and the dcdB gene, encoding dCMP deaminase
PMID 25746996

Diversity in Overall Activity Regulation of Ribonucleotide Reductase.

Jonna VR1, Crona M2, Rofougaran R1, Lundin D2, Johansson S1, Brännström K1, Sjöberg BM2, Hofer A3.
The Journal of biological chemistry.J Biol Chem.2015 May 13. pii: jbc.M115.649624. [Epub ahead of print]
Ribonucleotide reductase (RNR) catalyzes the reduction of ribonucleotides to the corresponding deoxyribonucleotides, which are used as building blocks for DNA replication and repair. This process is tightly regulated via two allosteric sites, the specificity site (s-site) and the overall activity si
PMID 25971975

Japanese Journal

Enzymatic characterization of human immunodeficiency virus type 1 reverse transcriptase for use in cDNA synthesis.

Konishi Atsushi,Shinomura Mayu,Yasukawa Kiyoshi
Applied biochemistry and biotechnology 169(1), 77-87, 2013-01
… In the incorporation of dTTP into poly(rA)-p(dT)(15) (T/P), the K (m) values for dTTP of HIV-1 M RT and HIV-1 O RT were 8 and 12 % of that of Moloney murine leukemia virus (MMLV) RT, respectively, and the K (m) values for T/P were 25 and 23 % of that of MMLV RT, respectively. …
NAID 120005241449

Kinetic analysis of reverse transcriptase activity of bacterial family A DNA polymerases.

Yasukawa Kiyoshi,Konishi Atsushi,Shinomura Mayu,Nagaoka Eriko,Fujiwara Shinsuke
Biochemical and biophysical research communications 427(3), 654-658, 2012-10-26
… In the incorporation of dTTP into poly(rA)-p(dT)(45), the reaction rates of K4pol(L329A) and M1pol(WT) exhibited a saturated profile of the Michaelis-Menten kinetics for dTTP concentrations but a substrate inhibition profile for poly(rA)-p(dT)(45) concentrations. … In contrast, the reaction rates of Moloney murine leukemia virus (MMLV) RT exhibited saturated profiles for both dTTP and poly(rA)-p(dT)(45) concentrations. …
NAID 120004945040

Biochemical Characterization of TT1383 from Thermus thermophilus Identifies a Novel dNTP Triphosphohydrolase Activity Stimulated by dATP and dTTP

Kondo Naoyuki,Kuramitsu Seiki,Masui Ryoji
The journal of biochemistry 136(2), 221-231, 2004-08-01
NAID 10016201562

Related Pictures

★リンクテーブル★

リンク元	「TTP」「チミジン三リン酸」「deoxythymidine triphosphate」「thymidine triphosphate」
関連記事	「dT」

「TTP」

Thymidine triphosphate
Names
	IUPAC name [(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl (hydroxy-phosphonooxyphosphoryl) hydrogen phosphate
	Other names dTTP, 2'-deoxythymidine triphosphate
Identifiers
CAS Number	365-08-2 =
ChEMBL	ChEMBL363559
ChemSpider	58493 =
IUPHAR/BPS	5505
Jmol interactive 3D	Image
MeSH	thymidine+5'-triphosphate
PubChem	64968
	SMILES CC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O ;
Properties
Chemical formula	C10H17N2O14P3
Molar mass	482.168
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	(what is ?)
	Infobox references