関: cAMP receptor

WordNet

of a compound having atoms arranged in a ring structure
recurring in cycles (同)cyclical
conforming to the Carnot cycle
forming a whorl or having parts arranged in a whorl; "cyclic petals"; "cyclic flowers"
marked by repeated cycles
the 1st letter of the Roman alphabet (同)a
the blood group whose red cells carry the A antigen (同)type_A, group A
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

PrepTutorEJDIC

answer / ampere
=sense organ / 受信装置

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/12/06 17:12:46」(JST)

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cAMP receptor protein (CRP; also known as catabolite activator protein, CAP) is a regulatory protein in bacteria. CRP protein binds cAMP, which causes a conformational change that allows CRP to bind tightly to a specific DNA site in the promoters of the genes it controls^[1]^[2] CRP then activates transcription through direct protein-protein interactions with RNA polymerase.^[1]^[2]

The genes regulated by CRP are mostly involved in energy metabolism, such as galactose, citrate, or the PEP group translocation system.^[3]^[4] In Escherichia coli, cyclic AMP receptor protein (CRP) can regulate the transcription of more than 100 genes.

The signal to activate CRP is the binding of cyclic AMP. Binding of cAMP to CRP leads to a long-distance signal transduction from the N-terminal cAMP-binding domain to the C-terminal domain of the protein, which is responsible for interaction with specific sequences of DNA.""^[5]

At "Class I" CRP-dependent promoters, CRP binds to a DNA site located upstream of core promoter elements and activates transcription through protein-protein interactions between "activating region 1" of CRP and the C-terminal domain of RNA polymerase alpha subunit.^[1]^[2]^[6] At "Class II" CRP-dependent promoters, CRP binds to a DNA site that overlaps the promoter -35 element and activates transcription through two sets of protein-protein interactions: (1) an interaction between "activating region 1" of CRP and the C-terminal domain of RNA polymerase alpha subunit, and (2) an interaction between "activating region 2" of CRP and the N-terminal domain of RNA polymerase alpha subunit.^[1]^[2] At "Class III" CRP-dependent promoters, CRP functions together with one or more "co-activator" proteins.^[1]^[2]

At most CRP-dependent promoters, CRP activates transcription primarily or exclusively through a "recruitment" mechanism, in which protein-protein interactions between CRP and RNA polymerase assist binding of RNA polymerase to the promoter.^[1]

References

^ ^a ^b ^c ^d ^e ^f Busby S., Ebright RH. (2001). "Transcription activation by catabolite activator protein (CAP)". J. Mol. Biol. 293: 199–213. doi:10.1006/jmbi.1999.3161. PMID 10550204.
^ ^a ^b ^c ^d ^e Lawson C.L., Swigon D., Murakami K.S., Darst S.A., Berman H.M., Ebright RH. (2004). "Catabolite activator protein: DNA binding and transcription activation". Curr. Opin. Struct. Biol. 14: 10–20. doi:10.1016/j.sbi.2004.01.012. PMID 15102444.
^ Weickert MJ, Adhya S (1993). "The galactose regulon of Escherichia coli". Mol. Microbiol. 10 (2): 245–51. doi:10.1111/j.1365-2958.1993.tb01950.x. PMID 7934815.
^ Bott M (1997). "Anaerobic citrate metabolism and its regulation in enterobacteria". Arch. Microbiol. 167 (2–3): 78–88. doi:10.1007/s002030050419. PMID 9133329.
^ Popovych, N.; Tzeng, S. -R.; Tonelli, M.; Ebright, R. H.; Kalodimos, C. G. (2009). "Structural basis for cAMP-mediated allosteric control of the catabolite activator protein". Proceedings of the National Academy of Sciences 106 (17): 6927–6932. doi:10.1073/pnas.0900595106. PMC 2678429. PMID 19359484. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2678429/. edit
^ Hudson, B. P.; Quispe, J.; Lara-Gonzalez, S.; Kim, Y.; Berman, H. M.; Arnold, E.; Ebright, R. H.; Lawson, C. L. (2009). "Three-dimensional EM structure of an intact activator-dependent transcription initiation complex". Proceedings of the National Academy of Sciences 106 (47): 19830–19835. doi:10.1073/pnas.0908782106. PMC 2775702. PMID 19903881. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2775702/. edit

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★リンクテーブル★

リンク元	「cAMP receptor」「サイクリックAMP受容体」「サイクリックAMPレセプター」
拡張検索	「cyclic AMP receptor protein」
関連記事	「cyclic」「A」「AM」「AMP」「cyclic AMP」

「cAMP receptor」

CAMP receptor protein
	Structure of the E. coli Cyclic AMP Receptor Protein.
Identifiers
Symbol	CRP
Alt. symbols	CAP
Entrez	947867
PDB	1I5Z
RefSeq	NP_417816.1
UniProt	P0ACJ8
Other data