サイクリックAMP受容体タンパク質
WordNet
- of a compound having atoms arranged in a ring structure
- recurring in cycles (同)cyclical
- conforming to the Carnot cycle
- forming a whorl or having parts arranged in a whorl; "cyclic petals"; "cyclic flowers"
- marked by repeated cycles
- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
- the 1st letter of the Roman alphabet (同)a
- the blood group whose red cells carry the A antigen (同)type_A, group A
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
PrepTutorEJDIC
- 蛋白(たんばく)質
- answer / ampere
- =sense organ / 受信装置
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/08/06 03:55:18」(JST)
[Wiki en表示]
Not to be confused with C-reactive protein.
| CAMP receptor protein |
|---|
|
Structure of the E. coli Cyclic AMP Receptor Protein. |
| Identifiers |
|---|
| Symbol |
CRP |
|---|
| Alt. symbols |
CAP |
|---|
| Entrez |
947867 |
|---|
| PDB |
1I5Z |
|---|
| RefSeq |
NP_417816.1 |
|---|
| UniProt |
P0ACJ8 |
|---|
cAMP receptor protein (CRP; also known as catabolite activator protein, CAP) is a regulatory protein in bacteria. CRP protein binds cAMP, which causes a conformational change that allows CRP to bind tightly to a specific DNA site in the promoters of the genes it controls.[1][2] CRP then activates transcription through direct protein–protein interactions with RNA polymerase.[1][2]
The genes regulated by CRP are mostly involved in energy metabolism, such as galactose, citrate, or the PEP group translocation system.[3][4] In Escherichia coli, cyclic AMP receptor protein (CRP) can regulate the transcription of more than 100 genes.
The signal to activate CRP is the binding of cyclic AMP. Binding of cAMP to CRP leads to a long-distance signal transduction from the N-terminal cAMP-binding domain to the C-terminal domain of the protein, which is responsible for interaction with specific sequences of DNA.[5]
At "Class I" CRP-dependent promoters, CRP binds to a DNA site located upstream of core promoter elements and activates transcription through protein–protein interactions between "activating region 1" of CRP and the C-terminal domain of RNA polymerase alpha subunit.[1][2][6] At "Class II" CRP-dependent promoters, CRP binds to a DNA site that overlaps the promoter -35 element and activates transcription through two sets of protein–protein interactions: (1) an interaction between "activating region 1" of CRP and the C-terminal domain of RNA polymerase alpha subunit, and (2) an interaction between "activating region 2" of CRP and the N-terminal domain of RNA polymerase alpha subunit.[1][2] At "Class III" CRP-dependent promoters, CRP functions together with one or more "co-activator" proteins.[1][2]
At most CRP-dependent promoters, CRP activates transcription primarily or exclusively through a "recruitment" mechanism, in which protein–protein interactions between CRP and RNA polymerase assist binding of RNA polymerase to the promoter.[1]
References
- ^ a b c d e f Busby S., Ebright RH. (1999). "Transcription activation by catabolite activator protein (CAP)". J. Mol. Biol. 293 (2): 199–213. doi:10.1006/jmbi.1999.3161. PMID 10550204.
- ^ a b c d e Lawson CL, Swigon D, Murakami KS, Darst SA, Berman HM, Ebright RH (2004). "Catabolite activator protein: DNA binding and transcription activation". Curr. Opin. Struct. Biol. 14 (1): 10–20. doi:10.1016/j.sbi.2004.01.012. PMC 2765107 . PMID 15102444.
- ^ Weickert MJ, Adhya S (1993). "The galactose regulon of Escherichia coli". Mol. Microbiol. 10 (2): 245–51. doi:10.1111/j.1365-2958.1993.tb01950.x. PMID 7934815.
- ^ Bott M (1997). "Anaerobic citrate metabolism and its regulation in enterobacteria". Arch. Microbiol. 167 (2–3): 78–88. doi:10.1007/s002030050419. PMID 9133329.
- ^ Popovych, N.; Tzeng, S. -R.; Tonelli, M.; Ebright, R. H.; Kalodimos, C. G. (2009). "Structural basis for cAMP-mediated allosteric control of the catabolite activator protein". Proceedings of the National Academy of Sciences. 106 (17): 6927–6932. doi:10.1073/pnas.0900595106. PMC 2678429 . PMID 19359484.
- ^ Hudson, B. P.; Quispe, J.; Lara-Gonzalez, S.; Kim, Y.; Berman, H. M.; Arnold, E.; Ebright, R. H.; Lawson, C. L. (2009). "Three-dimensional EM structure of an intact activator-dependent transcription initiation complex". Proceedings of the National Academy of Sciences. 106 (47): 19830–19835. doi:10.1073/pnas.0908782106. PMC 2775702 . PMID 19903881.
UpToDate Contents
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English Journal
- Mutations That Stimulate flhDC Expression in Escherichia coli K-12.
- Fahrner KA1, Berg HC2.
- Journal of bacteriology.J Bacteriol.2015 Oct 1;197(19):3087-96. doi: 10.1128/JB.00455-15. Epub 2015 Jul 13.
- Motility is a beneficial attribute that enables cells to access and explore new environments and to escape detrimental ones. The organelle of motility in Escherichia coli is the flagellum, and its production is initiated by the activating transcription factors FlhD and FlhC. The expression of these
- PMID 26170415
- Screening of the Human Kinome Identifies MSK1/2-CREB1 as an Essential Pathway Mediating Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication during Primary Infection.
- Cheng F1, Sawant TV1, Lan K2, Lu C3, Jung JU1, Gao SJ4.
- Journal of virology.J Virol.2015 Sep 15;89(18):9262-80. doi: 10.1128/JVI.01098-15. Epub 2015 Jun 24.
- Viruses often hijack cellular pathways to facilitate infection and replication. Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic gammaherpesvirus etiologically associated with Kaposi's sarcoma, a vascular tumor of endothelial cells. Despite intensive studies, cellular pathways mediatin
- PMID 26109721
- Screening of randomly mutagenized glucagon-like peptide-1 library by using an integrated yeast-mammalian assay system.
- Shigemori T1, Kuroda K1, Ueda M2.
- Journal of biotechnology.J Biotechnol.2015 Sep 10;209:96-101. doi: 10.1016/j.jbiotec.2015.06.392. Epub 2015 Jun 15.
- Glucagon-like peptide-1 (GLP1) is a 30-amino acid peptide hormone activating the GLP1 receptor (GLP1R), a class B G-protein coupled receptor (GPCR), and is considered to be effective for treating diabetes and other metabolic diseases. Phage display is the first innovative technology in order to prep
- PMID 26087314
Japanese Journal
- Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression
- Sucralose, an activator of the glucose-sensing receptor, increases ATP by calcium-dependent and -independent mechanisms
- Sucralose, an activator of the glucose-sensing receptor, increases ATP by calcium-dependent and -independent mechanisms
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★リンクテーブル★
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- 英
- cyclic AMP receptor protein CRP
- 同
- カタボライトアクチベーター蛋白質 catabolite activator protein CAP、カタボライト遺伝子アクチベーター蛋白質 catabolite gene activator protein
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- 英
- cyclic AMP receptor protein
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- 関
- annular、circular、cyclical、cyclicity、cyclo、periodic、periodicity
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アデノシン一リン酸 adenosine monophosphate adenosine 5'-monophosphate