WordNet

of a compound having atoms arranged in a ring structure
recurring in cycles (同)cyclical
conforming to the Carnot cycle
forming a whorl or having parts arranged in a whorl; "cyclic petals"; "cyclic flowers"
marked by repeated cycles
any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
the 1st letter of the Roman alphabet (同)a
the blood group whose red cells carry the A antigen (同)type_A, group A
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

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蛋白(たんばく)質
answer / ampere
=sense organ / 受信装置

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/08/06 03:55:18」(JST)

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cAMP receptor protein (CRP; also known as catabolite activator protein, CAP) is a regulatory protein in bacteria. CRP protein binds cAMP, which causes a conformational change that allows CRP to bind tightly to a specific DNA site in the promoters of the genes it controls.^[1]^[2] CRP then activates transcription through direct protein–protein interactions with RNA polymerase.^[1]^[2]

The genes regulated by CRP are mostly involved in energy metabolism, such as galactose, citrate, or the PEP group translocation system.^[3]^[4] In Escherichia coli, cyclic AMP receptor protein (CRP) can regulate the transcription of more than 100 genes.

The signal to activate CRP is the binding of cyclic AMP. Binding of cAMP to CRP leads to a long-distance signal transduction from the N-terminal cAMP-binding domain to the C-terminal domain of the protein, which is responsible for interaction with specific sequences of DNA.^[5]

At "Class I" CRP-dependent promoters, CRP binds to a DNA site located upstream of core promoter elements and activates transcription through protein–protein interactions between "activating region 1" of CRP and the C-terminal domain of RNA polymerase alpha subunit.^[1]^[2]^[6] At "Class II" CRP-dependent promoters, CRP binds to a DNA site that overlaps the promoter -35 element and activates transcription through two sets of protein–protein interactions: (1) an interaction between "activating region 1" of CRP and the C-terminal domain of RNA polymerase alpha subunit, and (2) an interaction between "activating region 2" of CRP and the N-terminal domain of RNA polymerase alpha subunit.^[1]^[2] At "Class III" CRP-dependent promoters, CRP functions together with one or more "co-activator" proteins.^[1]^[2]

At most CRP-dependent promoters, CRP activates transcription primarily or exclusively through a "recruitment" mechanism, in which protein–protein interactions between CRP and RNA polymerase assist binding of RNA polymerase to the promoter.^[1]

References

^ ^a ^b ^c ^d ^e ^f Busby S., Ebright RH. (1999). "Transcription activation by catabolite activator protein (CAP)". J. Mol. Biol. 293 (2): 199–213. doi:10.1006/jmbi.1999.3161. PMID 10550204.
^ ^a ^b ^c ^d ^e Lawson CL, Swigon D, Murakami KS, Darst SA, Berman HM, Ebright RH (2004). "Catabolite activator protein: DNA binding and transcription activation". Curr. Opin. Struct. Biol. 14 (1): 10–20. doi:10.1016/j.sbi.2004.01.012. PMC 2765107 . PMID 15102444.
^ Weickert MJ, Adhya S (1993). "The galactose regulon of Escherichia coli". Mol. Microbiol. 10 (2): 245–51. doi:10.1111/j.1365-2958.1993.tb01950.x. PMID 7934815.
^ Bott M (1997). "Anaerobic citrate metabolism and its regulation in enterobacteria". Arch. Microbiol. 167 (2–3): 78–88. doi:10.1007/s002030050419. PMID 9133329.
^ Popovych, N.; Tzeng, S. -R.; Tonelli, M.; Ebright, R. H.; Kalodimos, C. G. (2009). "Structural basis for cAMP-mediated allosteric control of the catabolite activator protein". Proceedings of the National Academy of Sciences. 106 (17): 6927–6932. doi:10.1073/pnas.0900595106. PMC 2678429 . PMID 19359484.
^ Hudson, B. P.; Quispe, J.; Lara-Gonzalez, S.; Kim, Y.; Berman, H. M.; Arnold, E.; Ebright, R. H.; Lawson, C. L. (2009). "Three-dimensional EM structure of an intact activator-dependent transcription initiation complex". Proceedings of the National Academy of Sciences. 106 (47): 19830–19835. doi:10.1073/pnas.0908782106. PMC 2775702 . PMID 19903881.

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English Journal

Mutations That Stimulate flhDC Expression in Escherichia coli K-12.

Fahrner KA1, Berg HC2.
Journal of bacteriology.J Bacteriol.2015 Oct 1;197(19):3087-96. doi: 10.1128/JB.00455-15. Epub 2015 Jul 13.
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Screening of the Human Kinome Identifies MSK1/2-CREB1 as an Essential Pathway Mediating Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication during Primary Infection.

Cheng F1, Sawant TV1, Lan K2, Lu C3, Jung JU1, Gao SJ4.
Journal of virology.J Virol.2015 Sep 15;89(18):9262-80. doi: 10.1128/JVI.01098-15. Epub 2015 Jun 24.
Viruses often hijack cellular pathways to facilitate infection and replication. Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic gammaherpesvirus etiologically associated with Kaposi's sarcoma, a vascular tumor of endothelial cells. Despite intensive studies, cellular pathways mediatin
PMID 26109721

Screening of randomly mutagenized glucagon-like peptide-1 library by using an integrated yeast-mammalian assay system.

Shigemori T1, Kuroda K1, Ueda M2.
Journal of biotechnology.J Biotechnol.2015 Sep 10;209:96-101. doi: 10.1016/j.jbiotec.2015.06.392. Epub 2015 Jun 15.
Glucagon-like peptide-1 (GLP1) is a 30-amino acid peptide hormone activating the GLP1 receptor (GLP1R), a class B G-protein coupled receptor (GPCR), and is considered to be effective for treating diabetes and other metabolic diseases. Phage display is the first innovative technology in order to prep
PMID 26087314

Japanese Journal

Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression

Molecular mtabolism 5(11), 1092-1102, 2016-11
NAID 120005893691

Sucralose, an activator of the glucose-sensing receptor, increases ATP by calcium-dependent and -independent mechanisms

Endocrine Journal 63(8), 715-725, 2016
NAID 130005261395

Sucralose, an activator of the glucose-sensing receptor, increases ATP by calcium-dependent and -independent mechanisms

Endocrine Journal advpub(0), 2016
NAID 130005154207

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★リンクテーブル★

リンク元	「サイクリックAMP受容蛋白質」「サイクリックAMP受容体タンパク質」
関連記事	「cyclic」「A」「AM」「receptor protein」「AMP」

「サイクリックAMP受容蛋白質」

CAMP receptor protein
	Structure of the E. coli Cyclic AMP Receptor Protein.
Identifiers
Symbol	CRP
Alt. symbols	CAP
Entrez	947867
PDB	1I5Z
RefSeq	NP_417816.1
UniProt	P0ACJ8