- 関
- lymphoma, cutaneous Tcell
WordNet
- small room in which a monk or nun lives (同)cubicle
- a device that delivers an electric current as the result of a chemical reaction (同)electric cell
- a room where a prisoner is kept (同)jail cell, prison cell
- (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
- any small compartment; "the cells of a honeycomb"
- a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
- relating to or existing on or affecting the skin; "cutaneous nerves"; "a cutaneous infection" (同)cutaneal, dermal
- the 20th letter of the Roman alphabet (同)t
- a neoplasm of lymph tissue that is usually malignant; one of the four major types of cancer
- a tough youth of 1950s and 1960s wearing Edwardian style clothes (同)Teddy boy
PrepTutorEJDIC
- (刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
- 皮膚の,皮膚を冒す
- tritiumの化学記号
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/03/16 21:05:39」(JST)
[Wiki en表示]
"CTCL" redirects here. For the book by Loren Pope, see Colleges That Change Lives.
| Cutaneous T cell lymphoma |
|
Micrograph showing cutaneous T-cell lymphoma. H&E stain.
|
| Classification and external resources |
| Specialty |
Hematology and oncology |
| ICD-10 |
C84.0, C84.1 |
| ICD-9 |
202.1, 202.2 |
| ICD-O: |
M9700/3, M9701/3 |
| DiseasesDB |
8595 |
| eMedicine |
med/3486 |
| MeSH |
D016410 |
Cutaneous T cell lymphoma (CTCL) is a class of non-Hodgkin lymphoma, which is a type of cancer of the immune system. Unlike most non-Hodgkin's lymphomas (which are generally B cell related), CTCL is caused by a mutation of T cells. The malignant T cells in the body initially migrate to the skin, causing various lesions to appear. These lesions change shape as the disease progresses, typically beginning as what appears to be a rash which can be very itchy and eventually forming plaques and tumors before metastasizing to other parts of the body.
Contents
- 1 Classification
- 2 Treatment
- 3 Epidemiology
- 4 See also
- 5 References
- 6 External links
§Classification
Cutaneous T-cell lymphomas may be divided into the following types:[1]:727–740
-
- Mycosis fungoides
- Pagetoid reticulosis
- Sézary syndrome
- Granulomatous slack skin
- Lymphomatoid papulosis
- Pityriasis lichenoides chronica
- Pityriasis lichenoides et varioliformis acuta
- CD30+ cutaneous T-cell lymphoma
- Secondary cutaneous CD30+ large cell lymphoma
- Non-mycosis fungoides CD30− cutaneous large T-cell lymphoma
- Pleomorphic T-cell lymphoma
- Lennert lymphoma
- Subcutaneous T-cell lymphoma
- Angiocentric lymphoma
- Blastic NK-cell lymphoma
A WHO-EORTC classification has been developed.[2][3]
§Treatment
There is no cure for CTCL, but there are a variety of treatment options available and some CTCL patients are able to live normal lives with this cancer, although symptoms can be debilitating and painful, even in earlier stages.
FDA approved treatments are :[4]
- (1999) Denileukin diftitox (Ontak)
- (2000) Bexarotene (Targretin) a retinoid
- (2006) Vorinostat (Zolinza) a hydroxymate histone deacetylase (HDAC) inhibitor
- (2009) Romidepsin (Istodax) a cyclic peptide histone deacetylase (HDAC) inhibitor
Other (off label) Treatments include:
- Topical and oral corticosteroids
- Bexarotene (Targretin) gel and capsules
- Carmustine (BCNU, a nitrosourea)
- Mechlorethamine (Nitrogen Mustard)
- Phototherapy (Broad & Narrow Band UVB or PUVA)
- Local & Total Skin Electron Beam Radiation
- Conventional Radiation Therapy
- Photopheresis
- Interferons
- Alemtuzumab (Campath-1H)
- Methotrexate
- Pentostatin and other purine analogues (Fludarabine, 2-deoxychloroadenosine)
- Liposomal doxorubicin (Doxil)
- Gemcitabine (Gemzar)
- Cyclophosphamide
- Bone marrow / stem cells
- Allogenic transplantation
- Forodesine (Inhibits Purine Nucleoside phosphorylase)
Other drugs are under investigation (for example panobinostat and Resimmune).
In 2010, the U.S. Food and Drug Administration granted orphan drug designation for a topical treatment for pruritus in cutaneous T-cell lymphoma to a pharmaceutical company called Elorac.[5]
§Epidemiology
Of all cancers involving the same class of blood cell, 2% of cases are cutaneous T cell lymphomas.[6]
There is some evidence of a relationship with human T-lymphotropic virus.[7]
§See also
- Cutaneous B-cell lymphoma
- List of cutaneous conditions
§References
- ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
- ^ Willemze, R.; Jaffe, ES.; Burg, G.; Cerroni, L.; Berti, E.; Swerdlow, SH.; Ralfkiaer, E.; Chimenti, S. et al. (May 2005). "WHO-EORTC classification for cutaneous lymphomas". Blood 105 (10): 3768–85. doi:10.1182/blood-2004-09-3502. PMID 15692063.
- ^ Khamaysi, Z.; Ben-Arieh, Y.; Izhak, OB.; Epelbaum, R.; Dann, EJ.; Bergman, R. (Feb 2008). "The applicability of the new WHO-EORTC classification of primary cutaneous lymphomas to a single referral center". Am J Dermatopathol 30 (1): 37–44. doi:10.1097/DAD.0b013e31815f9841. PMID 18212543.
- ^ http://www.istockanalyst.com/article/viewnewspaged/articleid/3622028/pageid/1
- ^ Elorac, Inc. Announces Orphan Drug Designation for Novel Topical Treatment for Pruritus in Cutaneous T-cell Lymphoma (CTCL) website
- ^ Turgeon, Mary Louise (2005). Clinical hematology: theory and procedures. Hagerstown, MD: Lippincott Williams & Wilkins. p. 283. ISBN 0-7817-5007-5.
Frequency of lymphoid neoplasms. (Source: Modified from WHO Blue Book on Tumour of Hematopoietic and Lymphoid Tissues. 2001, p. 2001.)
- ^ Nicot C (March 2005). "Current views in HTLV-I-associated adult T-cell leukemia/lymphoma". Am. J. Hematol. 78 (3): 232–9. doi:10.1002/ajh.20307. PMID 15726602.
§External links
- DermNet dermal-infiltrative/cutaneous-t-cell-lymphoma
- Information on cutaneous T-cell lymphomas from Lymphoma Information Network
- cutaneous T-cell lymphoma from H. Lee Moffitt Cancer Center & Research Institute
- The Cutaneous Lymphoma Foundation
- Skin Research Center lab Hopital St Louis, Paris (France) Dir. Dr. A. Bensussan
|
Hematological malignancy/leukemia histology (ICD-O 9590–9989, C81–C96, 200–208)
Lymphoid/Lymphoproliferative, Lymphomas/Lymphoid leukemias (9590–9739, 9800–9839)
|
|
B cell
(lymphoma,
leukemia)
(most CD19
|
|
By development/
marker
|
|
TdT+
|
- ALL (Precursor B acute lymphoblastic leukemia/lymphoma)
|
|
|
CD5+
|
mantle zone (Mantle cell)
|
|
|
CD22+
|
- Prolymphocytic
- CD11c+ (Hairy cell leukemia)
|
|
|
CD79a+
|
- germinal center/follicular B cell (Follicular
- Burkitt's
- GCB DLBCL
- Primary cutaneous follicular lymphoma)
marginal zone/marginal-zone B cell (Splenic marginal zone
- MALT
- Nodal marginal zone
- Primary cutaneous marginal zone lymphoma)
|
|
|
RS (CD15+, CD30+)
|
- Classic Hodgkin's lymphoma (Nodular sclerosis)
- CD20+ (Nodular lymphocyte predominant Hodgkin's lymphoma)
|
|
|
PCDs/PP
(CD38+/CD138+)
|
- see immunoproliferative immunoglobulin disorders
|
|
|
|
By infection
|
- KSHV (Primary effusion)
- EBV (Lymphomatoid granulomatosis
- Post-transplant lymphoproliferative disorder)
- HIV (AIDS-related lymphoma)
- Helicobacter pylori (MALT lymphoma)
|
|
|
Cutaneous
|
- Diffuse large B-cell lymphoma
- Intravascular large B-cell lymphoma
- Primary cutaneous marginal zone lymphoma
- Primary cutaneous immunocytoma
- Plasmacytoma
- Plasmacytosis
- Primary cutaneous follicular lymphoma
|
|
|
|
T/NK
|
T cell
(lymphoma,
leukemia)
(most CD3
|
|
By development/
marker
|
- TdT+: ALL (Precursor T acute lymphoblastic leukemia/lymphoma)
- prolymphocyte (Prolymphocytic)
- CD30+ (Anaplastic large-cell lymphoma
- Lymphomatoid papulosis type A)
|
|
|
Cutaneous
|
|
MF+variants
|
- indolent: Mycosis fungoides
- Pagetoid reticulosis
- Granulomatous slack skin
aggressive: Sézary disease
- Adult T-cell leukemia/lymphoma
|
|
|
Non-MF
|
- CD30-: Non-mycosis fungoides CD30− cutaneous large T-cell lymphoma
- Pleomorphic T-cell lymphoma
- Lymphomatoid papulosis type B
CD30+: CD30+ cutaneous T-cell lymphoma
- Secondary cutaneous CD30+ large cell lymphoma
- Lymphomatoid papulosis type A
|
|
|
|
Other peripheral
|
- Hepatosplenic
- Angioimmunoblastic
- Enteropathy-associated T-cell lymphoma
- Peripheral T-cell lymphoma-Not-Otherwise-Specified (Lennert lymphoma)
- Subcutaneous T-cell lymphoma
|
|
|
By infection
|
- HTLV-1 (Adult T-cell leukemia/lymphoma)
|
|
|
|
NK cell/
(most CD56)
|
- Aggressive NK-cell leukemia
- Blastic NK cell lymphoma
|
|
|
T or NK
|
- EBV (Extranodal NK-T-cell lymphoma/Angiocentric lymphoma)
- Large granular lymphocytic leukemia
|
|
|
|
Lymphoid+myeloid
|
- Acute biphenotypic leukaemia
|
|
|
Lymphocytosis
|
- Lymphoproliferative disorders (X-linked lymphoproliferative disease
- Autoimmune lymphoproliferative syndrome)
- Leukemoid reaction
- Diffuse infiltrative lymphocytosis syndrome
|
|
|
| Cutaneous lymphoid hyperplasia |
- Cutaneous lymphoid hyperplasia
- with bandlike and perivascular patterns
- with nodular pattern
- Jessner lymphocytic infiltrate of the skin
|
|
Index of the immune system
|
|
| Description |
- Physiology
- cells
- autoantigens
- autoantibodies
- complement
- surface antigens
- IG receptors
|
|
| Disease |
- Allergies
- Immunodeficiency
- Immunoproliferative immunoglobulin disorders
- Hypersensitivity and autoimmune disorders
- Neoplasms and cancer
|
|
| Treatment |
- Procedures
- Drugs
- immunostimulants
- immunosuppressants
- monoclonal antibodies
|
|
|
UpToDate Contents
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English Journal
- Regulation of cellular processes by interleukin-16 in homeostasis and cancer.
- Richmond J, Tuzova M, Cruikshank W, Center D.SourcePulmonary Center, Boston University School of Medicine, Boston, Massachusetts.
- Journal of cellular physiology.J Cell Physiol.2014 Feb;229(2):139-47. doi: 10.1002/jcp.24441.
- Interleukin-16 (IL-16) is generated as a precursor molecule that is cleaved by caspase-3 to produce a pro-IL-16 molecule that functions as a regulator of T cell growth, and a secreted peptide that functions as a CD4 and/or CD9 ligand for induction of cell motility and activation. IL-16 has been pred
- PMID 23893766
- CD20 Antigen May Be Expressed by Reactive or Lymphomatous Cells of Transformed Mycosis Fungoides: Diagnostic and Prognostic Impact.
- Jullié ML, Carlotti M, Vivot A Jr, Beylot-Barry M, Ortonne N, Frouin E, Carlotti A, de Muret A, Balme B, Franck F, Merlio JP, Vergier B.Source*Department of Pathology, the Tumor Bank and Tumor Biology Laboratory, the departments of Statistics and Dermatology, University Hospital of Bordeaux †Departments of Pathology and Dermatology, University Hospital of Paris-Est Créteil ‡Departments of Pathology and Dermatology, University Hospital of Montpellier §Departments of Pathology and Dermatology, University Hospital of Paris, APHP ∥Departments of Pathology and Dermatology, University Hospital of Tours ¶Departments of Pathology and Dermatology, University Hospital of Lyon #Departments of Pathology and Dermatology, University Hospital of Clermont-Ferrand, France.
- The American journal of surgical pathology.Am J Surg Pathol.2013 Dec;37(12):1845-54. doi: 10.1097/PAS.0000000000000091.
- Mycosis fungoides (MF), the most common primitive cutaneous T-cell lymphoma, can undergo transformation in about 10% of cases. Transformed mycosis fungoides (T-MF) is often associated with the appearance of a CD20 component. The aim of this study was to analyze whether such cells are reactive or lym
- PMID 24145652
- Primary cutaneous gamma-delta T-cell lymphoma with marked pagetoid epidermotropism shortly after allogeneic stem cell transplantation.
- Bautista-Quach MA, Tong T, Nademanee A, Huang Q.SourceDepartment of Pathology, City of Hope National Medical Center, Duarte, CA.
- Clinical lymphoma, myeloma & leukemia.Clin Lymphoma Myeloma Leuk.2013 Dec;13(6):e6-9. doi: 10.1016/j.clml.2013.05.018. Epub 2013 Sep 11.
- PMID 24035713
Japanese Journal
- 皮膚T細胞リンパ腫治療におけるvorinostatの役割
- 藤井 のり子,長谷 哲男,谷 守
- Skin Cancer 28(1), 98-102, 2013
- … Mycosis fungoides（MF）やそのlarge cell transformationとするには，Pautrier微小膿瘍やmycosis細胞はみられず，真皮浸潤細胞は小型リンパ球，異型大型細胞，組織球など多彩で，免疫組織化学も多彩。 … Cutaneous anaplastic large cell lymphomaとするにはCD30の陽性率が低く，lymphomatoid papulosisは臨床像が当てはまらなかった。 …
- NAID 130003378176
- 岡崎 雅,後藤 崇成,川口 和浩 [他],鈴木 豊
- 耳鼻咽喉科臨床 106(3), 241-245, 2013
- … Mycosis fungoides (MF) is the most common type of cutaneous malignant T-cell lymphoma, but reports of MF in the head and neck region are rare. …
- NAID 130003374031
Related Links
- LRF is the largest non-profit organization in the nation devoted exclusively to funding innovative lymphoma research and providing people with lymphoma and healthcare professionals with up-to-date information about this type of ...
- Cutaneous T cell lymphomaとは？goo Wikipedia (ウィキペディア) 。出典：Wikipedia（ウィキペディア）フリー百科事典。 Cutaneous T cell lymphomaとは - goo Wikipedia (ウィキペディア) gooトップ サイトマップ スタートページに設定 RSS ...
Related Pictures
★リンクテーブル★
[★]
- 英
- cutaneous T-cell lymphoma、CTCL
- 関
- 皮膚T細胞性リンパ腫
[★]
- 英
- cutaneous T-cell lymphoma、CTCL
- 関
- 皮膚T細胞リンパ腫
[★]
[★]
- 関
- cutaneously、cutis、dermal、skin
[★]
細胞
