- 関
- corticotropin-releasing hormone、CRF
WordNet
- be a contributing factor; "make things factor into a companys profitability"
- any of the numbers (or symbols) that form a product when multiplied together
- an independent variable in statistics
- anything that contributes causally to a result; "a number of factors determined the outcome"
- consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
- resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
- an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
- a concept whose truth can be proved; "scientific hypotheses are not facts"
- a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
- a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
PrepTutorEJDIC
- (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
- 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/02/25 10:03:45」(JST)
[Wiki en表示]
Corticotropin-releasing factor family |
Identifiers |
Symbol |
CRF |
Pfam |
PF00473 |
InterPro |
IPR000187 |
PROSITE |
PDOC00442 |
SCOP |
1goe |
SUPERFAMILY |
1goe |
Available protein structures: |
Pfam |
structures |
PDB |
RCSB PDB; PDBe |
PDBsum |
structure summary |
|
Corticotropin-releasing factor, CRF is a family of related neuropeptides in vertebrates. This family includes corticotropin-releasing hormone, urotensin-I, urocortin and sauvagine. The family can be grouped into 2 separate paralogous lineages, with urotensin-I, urocortin and sauvagine in one group and CRH forming the other group. Urocortin and sauvagine appear to represent orthologues of fish urotensin-I in mammals and amphibians, respectively. The peptides have a variety of physiological effects on stress and anxiety, vasoregulation, thermoregulation, growth and metabolism, metamorphosis and reproduction in various species, and are all released as prohormones.[1]
Corticotropin-releasing hormone (CRH) [2] is a hormone found mainly in the paraventricular nucleus of the mammalian hypothalamus which regulates the release of corticotropin (ACTH) from the pituitary gland. The paraventricular nucleus transports CRH to the anterior pituitary, stimulating adrenocorticotropic hormone (ACTH) release via CRH type 1 receptors, thereby activating the hypothalamic–pituitary–adrenal axis (HPA) and thus glucocorticoid release.
CRH is evolutionary related to a number of other active peptides. Urocortin acts in vitro to stimulate the secretion of adrenocorticotropic hormone. Urotensin is found in the teleost caudal neurosecretory system and may play a role in osmoregulation and as a corticotropin-releasing factor. Urotensin-I is released from the urophysis of fish, and produces ACTH and subsequent cortisol release in vivo. The nonhormonal portion of the prohormone is thought to be the urotensin binding protein (urophysin). Sauvagine (P01144), isolated from frog skin, has a potent hypotensive and diuretic effect.
Subfamilies
- Urocortin IPR003620
- Diuretic hormone IPR003621
Human proteins from this family
CRH; UCN;
References
- ^ Balment RJ, Lovejoy DA (1999). "Evolution and physiology of the corticotropin-releasing factor (CRF) family of neuropeptides in vertebrates". Gen. Comp. Endocrinol. 115 (1): 1–22. PMID 10375459.
- ^ Lederis KP, Okawara Y, Richter D, Morley SD (1990). "Evolutionary aspects of corticotropin releasing hormones". Prog. Clin. Biol. Res. 342: 467–472. PMID 2200028.
This article incorporates text from the public domain Pfam and InterPro IPR000187
UpToDate Contents
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English Journal
- Peripheral corticotropin-releasing factor (CRF) induces stimulation of gastric contractions in freely moving conscious rats: role of CRF receptor types 1 and 2.
- Nozu T, Tsuchiya Y, Kumei S, Takakusaki K, Okumura T.SourceDepartment of Regional Medicine and Education, Asahikawa Medical University, Asahikawa, Japan Department of General Medicine, Asahikawa Medical University, Asahikawa, Japan Research Center for Brain Function and Medical Engineering, Asahikawa Medical University, Asahikawa, Japan.
- Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.Neurogastroenterol Motil.2013 Feb;25(2):190-7. doi: 10.1111/nmo.12050. Epub 2012 Dec 4.
- Background Peripheral corticotrophin-releasing factor (CRF) plays an important role in stress-induced alterations of gastrointestinal motility. CRF injected peripherally inhibits gastric emptying, but its effect on gastric contractions has not been clarified in freely moving conscious rats. Metho
- PMID 23205497
- Corticotropin-releasing hormone (CRH) is expressed in the human cervical carcinoma cells (HeLa) and upregulates the expression of Fas ligand.
- Taliouri E, Vrekoussis T, Vergetaki A, Agorastos T, Makrigiannakis A.SourceLaboratory of Human Reproduction, Department of Obstetrics and Gynecology, Medical School, University of Crete, Heraklion, 710 03, Crete, Greece.
- Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.Tumour Biol.2013 Feb;34(1):125-30. doi: 10.1007/s13277-012-0519-8. Epub 2012 Oct 18.
- Corticotropin-releasing hormone acts as a stressor mediator in the human reproductive system. Corticotropin-releasing hormone (CRH) has been detected in several carcinomas of gynecological origin like breast, ovarian, and endometrial carcinomas. It was additionally shown that CRH could induce Fas li
- PMID 23076876
- Sex differences in stress-related receptors: [prime][prime]micro[prime][prime] differences with [prime][prime]macro[prime][prime] implications for mood and anxiety disorders.
- Bangasser DA.AbstractABSTRACT: Stress-related psychiatric disorders, such as unipolar depression and post-traumatic stress disorder (PTSD), occur more frequently in women than in men. Emerging research suggests that sex differences in receptors for the stress hormones, corticotropin releasing factor (CRF) and glucocorticoids, contribute to this disparity. For example, sex differences in CRF receptor binding in the amygdala of rats may predispose females to greater anxiety following stressful events. Additionally, sex differences in CRF receptor signaling and trafficking in the locus coeruleus arousal center combine to make females more sensitive to low levels of CRF, and less adaptable to high levels. These receptor differences in females could lead to hyperarousal, a dysregulated state associated with symptoms of depression and PTSD. Similar to the sex differences observed in CRF receptors, sex differences in glucocorticoid receptor (GR) function also appear to make females more susceptible to dysregulation following a stressful event. Following hypothalamic pituitary adrenal axis activation, GRs are critical to the negative feedback process that inhibits additional glucocorticoid release. Compared to males, female rats have fewer GRs and impaired GR translocation following chronic adolescent stress, effects linked to slower glucocorticoid negative feedback. Thus, under conditions of chronic stress, attenuated negative feedback in females would result in hypercortisolemia, an endocrine state thought to cause depression. Together, these studies suggest that sex differences in stress-related receptors shift females more easily into a dysregulated state of stress reactivity, linked to the development of mood and anxiety disorders. The implications of these receptor sex differences for the development of novel pharmacotherapies are also discussed.
- Biology of sex differences.Biol Sex Differ.2013 Jan 21;4(1):2. [Epub ahead of print]
- ABSTRACT: Stress-related psychiatric disorders, such as unipolar depression and post-traumatic stress disorder (PTSD), occur more frequently in women than in men. Emerging research suggests that sex differences in receptors for the stress hormones, corticotropin releasing factor (CRF) and glucocorti
- PMID 23336736
Japanese Journal
- CRFおよびurocortinによる消化管機能の調節 (特集 拡がりゆく神経内分泌学の現状と展望)
- ストレス関連ペプチドと機能性胃腸症 (特集 機能性消化管障害の病態と治療)
- Age-Dependent Changes in the mRNA Levels of Neuropeptide Y, Proopiomelanocortin, and Corticotropin-Releasing Factor in the Hypothalamus in Growing Broiler Chicks
- Saneyasu Takaoki,Nakanishi Kiwako,Atsuta Hiroyuki [他]
- Journal of poultry science 50(4), 364-369, 2013-10
- NAID 40019836735
Related Links
- cor·ti·co·tro·pin-re·leas·ing hor·mone (CRH), a factor secreted by the hypothalamus that stimulates the pituitary to release adrenocorticotropic hormone. Synonym(s): corticotropin-releasing factor cor·ti·co·tro·pin-re·leas·ing hor·mone ...
- Florio P, Severi FM, Ciarmela P, et al. (2003). Placental stress factors and maternal-fetal adaptive response: the corticotropin-releasing factor family.. Endocrine 19 (1): 91-102. Florio P, Rossi M, Sigurdardottir M, et al. (2004).
Related Pictures
★リンクテーブル★
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- 英
- corticotropin-releasing factor, corticotropin releasing factor CRF
- 同
- コルチコトロピン放出因子
- 関
- 連続強化。副腎皮質刺激ホルモン放出ホルモン corticotropin-releasing hormone CRH
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- 関
- CRF receptor
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- 関
- actual、actually、in fact、in practice、indeed、practically
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- 関
- element、elementary、factorial、parameter
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