UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 救急外来における眼部損傷の概要overview of eye injuries in the emergency department [show details]
… Corneal abrasions and foreign bodies are common eye injuries. Clinical features of these injuries are as follows : Corneal abrasion – Patients with corneal abrasions report… eye injuries including vision-threatening and common conditions are provided. Rapid recognition and treatment of ocular chemical burns, orbital compartment syndrome, or open-globe injuries are essential…
2. コンタクトレンズの合併症complications of contact lenses [show details]
…lenses may cause defects of the corneal epithelium through mechanical trauma, oxygen deprivation, nutrient starvation, metabolic injury, hypersensitivity, drying, or chemical toxicity. Epithelial defects …
3. 救急外来における眼部損傷に対するアプローチapproach to eye injuries in the emergency department [show details]
… thickness corneal laceration – Incomplete corneal break without loss of aqueous humor; Other closed globe injuries include: Conjunctival abrasion – Injury to the epithelium of the conjunctiva; Corneal abrasion… : Identify and treat chemical exposure involving the eye(s) – The clinician should determine if chemical eye exposure has occurred. Patients with chemical eye exposure should receive…
4. 小児における急性視力低下へのアプローチapproach to acute vision loss in children [show details]
… evaluate for serious corneal injury (eg, chemical burn) or traumatic hyphema. Damage to posterior structures (eg, lens, retina, vitreous, optic nerve) often coexists with corneal chemical burns or traumatic …
5. 局所の化学熱傷：初期評価およびマネージメントtopical chemical burns initial assessment and management [show details]
… chemical ingestions, chemical eye injuries, and agents used for chemical warfare are discussed elsewhere.… the essential first aid for chemical burns of the skin and eye, reducing the risk for chronic conjunctivitis and sight-threatening corneal ulceration.…

English Journal

A self-healing hydrogel eye drop for the sustained delivery of decorin to prevent corneal scarring.

Chouhan G, Moakes RJA, Esmaeili M, Hill LJ, deCogan F, Hardwicke J, Rauz S, Logan A, Grover LM.
Biomaterials. 2019 Jul;210()41-50.
Scarring/Opacity on the surface of the eye and vascularisation following infectious diseases, inflammation and corneal trauma are often a leading cause of blindness. The 'gold standard' treatment to prevent corneal scarring is the application of amniotic membrane (AM) to the ocular surface in the ac
PMID 31055049

Adherence to Treatment and Follow-Up in Patients with Severe Chemical Eye Burns.

Bizrah M, Yusuf A, Ahmad S.
Ophthalmology and therapy. 2019 Jun;8(2)251-259.
To investigate the demographics, acute management and compliance rates of severe chemical eye burn cases that presented to the largest eye hospital in the United Kingdom (UK). All patients presenting to the Moorfields Eye Hospital emergency department are registered on the electronic patient admini
PMID 30868417

The clinical toxicology of sodium hypochlorite.

Slaughter RJ, Watts M, Vale JA, Grieve JR, Schep LJ.
Clinical toxicology (Philadelphia, Pa.). 2019 May;57(5)303-311.
Sodium hypochlorite is used as a bleaching and disinfecting agent and is commonly found in household bleach. The objective is to review critically the epidemiology, mechanisms of toxicity, clinical features, diagnosis, and management of hypochlorite poisoning. PubMed was searched from January 1950 t
PMID 30689457

Japanese Journal

Histopathological evaluation of the ocular-irritation potential of shampoos, make-up removers and cleansing foams in the bovine corneal opacity and permeability assay

Furukawa Masatoshi,Sakakibara Takashi,Itoh Kouta [他],Kawamura Kohtaro,Sasaki Satoshi,Matsuura Masao
Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃ　Ｐａｔｈｏｌｏｇｙ 28(4), 243-248, 2015
… The bovine corneal opacity and permeability (BCOP) assay is an alternative method to the <i>in vivo</i> … The histopathological score was defined based on the severity of lesions in the corneal epithelium. … irritancy score (IVIS) generally corresponds to the corneal irritant potential of the test substances assigned on the basis of the histopathological findings in this study. …
NAID 130005102945

油性塗料による創部汚染を伴った口腔顔面裂創の1例

藤武智,山家誠,高橋誠 [他],荒川美貴子,村瀬雄一,上田実
日本口腔外科学会雑誌 55(6), 286-290, 2009-06-20
… An ophthalmic surgeon diagnosed corneal ulcers and immediately irrigated the eyes with saline. … To prevent infection and chemical injury, an antibiotic was given, and irrigation was continued. … He was discharged on the 7th day after the injury because wound healing was acceptable. …
NAID 10027090563

Essential contribution of CCL3 to alkali-induced corneal neovascularization by regulating vascular endothelial growth factor production by macrophages

Lu Peirong,Li Longbiao,Wu Yu Ying,Mukaida Naofumi,Zhang Xueguang Guang
Molecular Vision (14), 1614-1622, 2008-09-01
… 金沢大学がん研究所がん病態制御Purpose: To evaluate the roles of CCL3 and its specific chemokine receptors, CCR1 and CCR5, in alkali-induced corneal neovascularization (CNV). … Methods: Chemical denudation of corneal and limbal epithelium was performed on wild-type (WT) BALB/c mice and CCL3-, CCR1-, and CCR5-deficienct (knockout [KO]) counterparts. … Two weeks after injury CNV was quantified by immunostaining with anti-CD31. …
NAID 120001658167