WordNet

part with a possession or right; "I am relinquishing my bedroom to the long-term house guest"; "resign a claim to the throne" (同)relinquish, resign, free, give_up
a process that liberates or discharges something; "there was a sudden release of oxygen"; "the release of iodine from the thyroid gland"
a device that when pressed will release part of a mechanism (同)button
activity that frees or expresses creative energy or emotion; "she had no other outlet for her feelings"; "he gave vent to his anger" (同)outlet, vent
(music) the act or manner of terminating a musical phrase or tone (同)tone ending
a formal written statement of relinquishment (同)waiver, discharge
merchandise issued for sale or public showing (especially a record or film); "a new release from the London Symphony Orchestra"
release (gas or energy) as a result of a chemical reaction or physical decomposition (同)free, liberate
restrained or managed or kept within certain bounds; "controlled emotions"; "the controlled release of water from reservoirs"

PrepTutorEJDIC

(束縛・義務などから)〈人・動物など〉‘を'『自由にする』,解放する《+『名』+『from』+『名』》 / 〈矢など〉‘を'放つ,〈爆弾〉‘を'投下する;〈締めつけた物〉‘を'ゆるめて放す / 〈ニュースなど〉‘を'発表する;〈レコード・書籍など〉‘を'発売する,〈映画〉‘を'封切りする / (人に)〈権利など〉‘を'譲渡する《+『名』+『to』+『名』》 / (束縛・義務などからの)『解放』,放免,免除《+『from』+『名』》 / (ガスなどの)放出;(爆弾の)投下;(感情の)吐露《+『of』(『to』)+『名』》 / (ニュースなどの)発表;(映画などの)封切り,(レコードなどの)発表 / (機械の)作動装置,レリーズ

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/08/22 14:18:09」(JST)

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Controlled release is a term referring to the presentation or delivery of compounds in response to stimuli or time. This can be for purposes in several areas including agriculture, cosmetics and personal care, pharmaceuticals and food science. Most commonly it refers to time dependent release in oral dose formulations. Timed release has several distinct variants such as sustained release where prolonged release is intended, pulse release, delayed release (e.g. to target different regions of the GI tract) etc. A distinction of controlled release is that not only prolongs action but it attempts to maintain drug levels within the therapeutic window to avoid potentially hazardous peaks in drug concentration following ingestion or injection and to maximize therapeutic efficiency.

The science of controlled release originates from the development of oral sustained-release products in the late 1940s and early 1950s, the development of controlled release of marine anti-foulants in the 1950s and controlled release fertilizer in the 1970s where sustained and controlled delivery of nutrients following a single application to the soil. Delivery is usually effected by dissolution, degradation or disintegration of an excipient in which the active compound is formulated. Enteric coating and other encapsulation technologies can further modify release profiles.

In addition to pills, capsules and injectable drug carriers (that often have an additional release function), forms of controlled release medicines include gels, implants and devices (e.g. the Vaginal ring and contraceptive implant) and transdermal patches.

Examples of stimuli that may be used to bring about release include pH, enzymes, light, magnetic fields, temperature, ultrasonics, osmosis and more recently electronic control of MEMS and NEMS.^[1]^[2]

Examples of cosmetics, personal care and food science applications often centre on odour or flavour release.

The release technology scientific and industrial community is represented by the Controlled Release Society (CRS). The CRS is the worldwide society for delivery science and technologies. CRS serves more than 1,600 members from more than 50 countries. Two-thirds of CRS membership is represented by industry and one-third represents academia and government. CRS is affiliated with the Journal of Controlled Release and Drug Delivery and Translational Research scientific journals.

External links[edit source | edit]

Controlled Release Society
Controlled Release Technology 5-day short course at MIT with Professor Robert Langer.

Footnotes[edit source | edit]

^ http://www.duke.edu/~jbl2/BME265/fulltext.pdf
^ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002303/

This pharmacology-related article is a stub. You can help Wikipedia by expanding it.

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English Journal

Stimulus-response mesoporous silica nanoparticle-based chemiluminescence biosensor for cocaine determination.

Chen Z1, Tan Y1, Xu K1, Zhang L2, Qiu B1, Guo L1, Lin Z3, Chen G1.
Biosensors & bioelectronics.Biosens Bioelectron.2016 Jan 15;75:8-14. doi: 10.1016/j.bios.2015.08.006. Epub 2015 Aug 6.
Mesoporous silica nanoparticles (MSN) based controlled release system had been coupled with diverse detection technologies to establish biosensors for different targets. Chemiluminescence (CL) system of luminol/H2O2 owns the characters of simplicity, low cost and high sensitivity, but the targets of
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Application of nano-encapsulated olive leaf extract in controlling the oxidative stability of soybean oil.

Mohammadi A1, Jafari SM2, Esfanjani AF1, Akhavan S1.
Food chemistry.Food Chem.2016 Jan 1;190:513-9. doi: 10.1016/j.foodchem.2015.05.115. Epub 2015 May 29.
Our objective was to evaluate the antioxidant activity of olive leave extract (OLE) encapsulated by nano-emulsions in soybean oil. The average droplet size one day after production was 6.16 nm for primary W/O nano-emulsion and, 675 nm and 1443 nm for multiple emulsions stabilized by WPC alone and co
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Drug Delivery Strategies of Chemical CDK Inhibitors.

Alvira D1, Mondragón L.
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The pharmacological use of new therapeutics is often limited by a safe and effective drug-delivery system. In this sense, new chemical CDK inhibitors are not an exception. Nanotechnology may be able to solve some of the main problems limiting cancer treatments such as more specific delivery of thera
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Japanese Journal

Highlighted Paper selected by Editor-in-Chief : Sustained Release of Mitomycin C from Its Conjugate with Single-Walled Carbon Nanotubes Associated by Pegylated Peptide

Biological & pharmaceutical bulletin 39(10), 1687-1693, 2016-10
NAID 40020945768

先端医療を支えるコントロールドリリース技術 (特集コントロールドリリースの臨床的価値と新たな方向性)

Drug delivery system : DDS : official journal of the Japan Society of Drug Delivery System 31(3), 219-227, 2016-07
NAID 40020918629

経口コントロールドリリース製剤技術を用いた製品開発と最近の動向 (特集コントロールドリリースの臨床的価値と新たな方向性)

Drug delivery system : DDS : official journal of the Japan Society of Drug Delivery System 31(3), 210-218, 2016-07
NAID 40020918624

Related Pictures

★リンクテーブル★

リンク元	「徐放」「放出制御」「コントロールドリリース」「sustained release」
拡張検索	「controlled-release preparation」「controlled-release tablet」「controlled-release」
関連記事	「release」