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a small tube

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小管,細管

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/04/04 17:49:33」(JST)

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In the kidney, the connecting tubule (CNT, or junctional tubule, or arcuate renal tubule) is a tubular segment of the renal collecting duct system that connects the distal convoluted tubule to the cortical collecting duct.

Structure

Many sources include the connecting tubule as part of the collecting duct system. However, the embryological origin is more similar to the nephron than it is to the rest of the collecting duct (which derives from the ureteric bud), and other sources therefore classify the connecting tubule with the nephron.

Some connecting tubules, usually associated with juxtamedullary nephrons, arch upwards before reaching the cortical collecting ducts. It is this "arcuate" feature which gives the tubule its alternate name.

Function

It participates in the regulation of water and electrolytes, including sodium, and chloride.

The CNT is sensitive to both isoprotenerol (more so than the cortical collecting ducts) and antidiuretic hormone (less so than the cortical collecting ducts), the latter largely determining its function in water reabsorption.

References

Eaton, Douglas C.; Pooler, John P. (2004). Vander's Renal Physiology (6th ed.). Lange Medical Books/McGraw-Hill. ISBN 0-07-135728-9.
Imai M (1979). "The connecting tubule: a functional subdivision of the rabbit distal nephron segments". Kidney Int. 15 (4): 346–56. doi:10.1038/ki.1979.46. PMID 513494.

External links

Physiology: 7/7ch03/7ch03p18 - Essentials of Human Physiology
Types of tubules at ndif.org
Diagram (#31) at benet.org

UpToDate Contents

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1. 腎集合管ナトリウムチャンネルの遺伝的障害：リドル症候群および偽性低アルドステロン症1型 genetic disorders of the collecting tubule sodium channel liddles syndrome and pseudohypoaldosteronism type 1
2. 腎尿細管性アシドーシスの概要と病態生理、およびカリウムバランスへの影響 overview and pathophysiology of renal tubular acidosis and the effect on potassium balance
3. Diuretics and calcium balance
4. 腎性尿崩症の臨床症状および原因 clinical manifestations and causes of nephrogenic diabetes insipidus
5. 利尿剤の作用機序 mechanism of action of diuretics

English Journal

Characterization of constitutive and acid-induced outwardly rectifying chloride currents in immortalized mouse distal tubular cells.

Valinsky WC1, Touyz RM2, Shrier A3.
Biochimica et biophysica acta.Biochim Biophys Acta.2017 Aug;1861(8):2007-2019. doi: 10.1016/j.bbagen.2017.05.004. Epub 2017 May 5.
PMID 28483640

Role of Collecting Duct Renin in the Pathogenesis of Hypertension.

Gonzalez AA1, Lara LS2, Prieto MC3.
Current hypertension reports.Curr Hypertens Rep.2017 Aug;19(8):62. doi: 10.1007/s11906-017-0763-9.
PMID 28695400

Modeling glucose metabolism and lactate production in the kidney.

Chen Y1, Fry BC2, Layton AT3.
Mathematical biosciences.Math Biosci.2017 Jul;289:116-129. doi: 10.1016/j.mbs.2017.04.008. Epub 2017 May 8.
PMID 28495544

Japanese Journal

Distinct Cytoplasmic Expression of KL-6 Mucin in Chromophobe Renal Cell Carcinoma: A Comparative Immunohistochemical Study with Other Renal Epithelial Cell Tumors

Fukushima Mana,Higuchi Kayoko,Shimojo Hisashi,Uehara Takeshi,Ota Hiroyoshi
ACTA HISTOCHEMICA ET CYTOCHEMICA 45(5), 301-308, 2012
… Cytoplasmic expression of KL-6 and sialyl MUC1 was distinctive in the chromophobe RCC and renal oncocytoma cells, and in the intercalated cells in collecting duct epithelia. … Apical-surface staining of these sialyl glycoproteins was predominantly observed in clear RCC, in the epithelia of the distal tubule and collecting duct, and in the neonatal renal proximal tubule, but not in those of the adult renal proximal tubule. …
NAID 130001854260

Juvenile Nephropathy in a Boxer Dog Resembling the Human Nephronophthisis-Medullary Cystic Kidney Disease Complex

BASILE Angelo,ONETTI-MUDA Andrea,GIANNAKAKIS Konstantinos [他],FARAGGIANA Tullio,ARESU Luca
Journal of Veterinary Medical Science 73(12), 1669-1675, 2011
… Lectin histochemistry investigation revealed that the cysts originated in the distal convoluted tubule and collecting duct. …
NAID 130001032789

Cell proliferative activity in the kidney of young growing rat analyzed using flash and cumulative labeling with bromodeoxyuridine

Suzuki Masami,Isobe Kaori,Fujii Etsuko [他],YAMAZAKI Masaki,TAKAI Yayoi,SOSHIN Tomomi,AKAI Sho,WATANABE Takeshi,KATO Atsuhiko
Journal of toxicological sciences 35(5), 631-637, 2010-10-01
… In the tubular epithelium, the majority of positive cells were found in the proximal tubule. … In the proximal tubule, positive epithelia were abundant in the medullary rays and in the outer stripe of the outer medulla. … In the intermediate tubule to collecting duct, positive epithelia were rare. …
NAID 10026668941

Related Pictures

★リンクテーブル★

リンク元	「集合管」「kidney collecting duct」「collecting kidney tubule」
関連記事	「tubule」

「集合管」

Connecting tubule
	Scheme of renal tubule and its vascular supply.
Details
Precursor	Metanephric blastema
Latin	tubulus renalis arcuatus
Dorlands; /Elsevier	t_22/12830099
	Anatomical terminology [edit on Wikidata]