- np.
WordNet
- a small canal or duct as in some bones and parts of plants
- a small tube
- relating to or like or having a canaliculus
- vein of the cochlear canal
PrepTutorEJDIC
- 小管,細管
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/01/14 05:03:02」(JST)
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- 1. 小児における鼻涙管閉塞（涙管閉鎖症） nasolacrimal duct obstruction dacryostenosis in children
- 2. まぶた裂傷 eyelid lacerations
- 3. 骨格の正常な発達および骨形成ならびに骨吸収の調節 normal skeletal development and regulation of bone formation and resorption
- 4. 悪性肝腫瘍の病理 pathology of malignant liver tumors
- 5. 歯の解剖学的構造および発達 anatomy and development of the teeth
English Journal
- Transport mechanisms of hepatic uptake and bile excretion in clinical hepatobiliary scintigraphy with (99m)Tc-N-pyridoxyl-5-methyltryptophan.
- Kobayashi M1, Nakanishi T2, Nishi K3, Higaki Y4, Okudaira H3, Ono M3, Tsujiuchi T3, Mizutani A3, Nishii R5, Tamai I2, Arano Y6, Kawai K3.Author information 1School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan. Electronic address: kobayasi@mhs.mp.kanazawa-u.ac.jp.2School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.3School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.4Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan; Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.5Department of Radiology, Faculty of Medicine University of Miyazaki, Miyazaki, Japan.6Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.AbstractINTRODUCTION: In clinical hepatobiliary scintigraphy, (99m)Tc-N-pyridoxyl-5-methyltryptophan ((99m)Tc-PMT) is an effective radiotracer among the (99m)Tc-pyridoxylaminates. However, the mechanisms of human hepatic uptake and bile excretion transport of (99m)Tc-PMT have not been determined. We thus investigated the transport mechanisms of human hepatic uptake and bile excretion in hepatobiliary scintigraphy with (99m)Tc-PMT.
- Nuclear medicine and biology.Nucl Med Biol.2014 Apr;41(4):338-42. doi: 10.1016/j.nucmedbio.2014.01.004. Epub 2014 Jan 13.
- INTRODUCTION: In clinical hepatobiliary scintigraphy, (99m)Tc-N-pyridoxyl-5-methyltryptophan ((99m)Tc-PMT) is an effective radiotracer among the (99m)Tc-pyridoxylaminates. However, the mechanisms of human hepatic uptake and bile excretion transport of (99m)Tc-PMT have not been determined. We thus in
- PMID 24607436
- Confocal Imaging with a Fluorescent Bile Acid Analogue Closely Mimicking Hepatic Taurocholate Disposition.
- De Bruyn T1, Sempels W, Snoeys J, Holmstock N, Chatterjee S, Stieger B, Augustijns P, Hofkens J, Mizuno H, Annaert P.Author information 1Drug Delivery and Disposition, KU Leuven Department of Pharmaceutical and Pharmacological Sciences, O&N2, Leuven, 3000, Belgium.AbstractThis study aimed to characterize the in vitro hepatic transport mechanisms in primary rat and human hepatocytes of the fluorescent bile acid derivative N-(24-[7-(4-N,N-dimethylaminosulfonyl-2,1,3-benzoxadiazole)]amino-3α,7α,12α-trihydroxy-27-nor-5β-cholestan-26-oyl)-2'-aminoethanesulfonate (tauro-nor-THCA-24-DBD), previously synthesized to study the activity of the bile salt export pump (BSEP). The fluorescent bile acid derivative exhibited saturable uptake kinetics in suspended rat hepatocytes. Hepatic uptake was inhibited in the presence of substrates/inhibitors of the organic anion transporting polypeptide (Oatp) family and Na+ -taurocholate cotransporting peptide (Ntcp). Concentration-dependent uptake of the fluorescent bile acid was also saturable in Chinese hamster ovary cells transfected with rNtcp, hNTCP, OATP1B1, or OATP1B3. The fluorescent bile acid derivative was actively excreted in the bile canaliculi of sandwich-cultured rat and human hepatocytes (SCRH and SCHH), with a biliary excretion index (BEI) of 26% and 32%, respectively. In SCRH, cyclosporin A significantly decreased the BEI to 5%. Quantification by real-time confocal imaging further confirmed canalicular transport of the fluorescent bile acid derivative (BEI = 75%). We conclude that tauro-nor-THCA-24-DBD is a useful probe to study interference of drugs with NTCP/Ntcp- and BSEP/Bsep-mediated transport in fluorescence-based in vitro assays. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci.
- Journal of pharmaceutical sciences.J Pharm Sci.2014 Mar 20. doi: 10.1002/jps.23933. [Epub ahead of print]
- This study aimed to characterize the in vitro hepatic transport mechanisms in primary rat and human hepatocytes of the fluorescent bile acid derivative N-(24-[7-(4-N,N-dimethylaminosulfonyl-2,1,3-benzoxadiazole)]amino-3α,7α,12α-trihydroxy-27-nor-5β-cholestan-26-oyl)-2'-aminoethanesulfonate (taur
- PMID 24652646
- Hepatocyte cocultures with endothelial cells and fibroblasts on micropatterned fibrous mats to promote liver-specific functions and capillary formation capabilities.
- Liu Y1, Li H, Yan S, Wei J, Li X.Author information 1Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University , Chengdu 610031, People's Republic of China.AbstractThe maintenance of hepatocyte phenotype and functions remains as a great challenge in the generation of functional liver tissue and in vitro model for drug metabolism studies. The use of hepatocyte coculture systems plays essential roles in the establishment of cell-cell and cell-extracellular matrix communications similar to native liver tissues. In the current study, micropatterned electrospun fibrous mats were created to load hepatocytes, fibroblasts, and endothelial cells (ECs), which were precisely assembled to establish their spatially controlled coculture for mimicking the in vivo structure of hepatic lobules. Hepatocytes formed compact polyhedral spheroids with an average diameter of 80-100 μm, reorganized actin filaments in the cell-cell contact regions, and well-developed bile canaliculi. Compared with hepatocytes cultured alone, the coculture of hepatocytes with either fibroblasts or ECs led to significantly higher albumin secretion, urea synthesis and cytochrome P-450 expression, which were dramatically improved by the coculture of hepatocytes with both fibroblasts and ECs. The cocultured ECs well spread on patterned regions with little organized filamentous actin, and significantly higher densities and deeper penetration into patterned scaffolds were determined for ECs after coculture with fibroblasts and hepatocytes compared with those after cultured alone or coculture with either fibroblasts or hepatocytes. A Matrigel overlay assay showed that the capabilities of ECs to form capillary tubes were significantly enhanced by micropatterned coculture with fibroblasts and hepatocytes. Thus, the coculture of hepatocytes, fibroblasts, and ECs on micropatterned fibrous mats helps both hepatocytes in the maintenance of hepatic functions and ECs in the formation of capillary-like structures. It is suggested that the micropatterned coculture model described here not only provides functional hepatic tissues for predictions of drug metabolism profiles, but also will enable investigations on more complex and physiological cell-cell communications.
- Biomacromolecules.Biomacromolecules.2014 Mar 10;15(3):1044-54. doi: 10.1021/bm401926k. Epub 2014 Feb 25.
- The maintenance of hepatocyte phenotype and functions remains as a great challenge in the generation of functional liver tissue and in vitro model for drug metabolism studies. The use of hepatocyte coculture systems plays essential roles in the establishment of cell-cell and cell-extracellular matri
- PMID 24547870
Japanese Journal
- GP2-expressing cells in the conjunctiva and tear ducts of mice: identification of a novel type of cells in the squamous stratified epithelium
- Biomedical Research 36(4), 263-272, 2015
- NAID 130005094141
- 種々の脊椎動物における骨細胞/骨細管系の比較形態学 (第86回日本整形外科学会学術総会 パネルディスカッション 骨代謝研究の進歩と臨床応用への展開)
- 日本整形外科学会雑誌 88(11), 860-863, 2014-11
- NAID 40020286838
- 720 骨細管のイメージベースモデルを用いた骨細胞突起変形シミュレーション(GS-2 筋・骨格)
- 関西支部講演会講演論文集 2014(89), "7-20", 2014-03-18
- NAID 110009965929
Related Links
- canaliculus [kan″ah-lik´u-lus] (pl. canali´culi) (L.) an extremely narrow tubular passage or channel. adj., adj canalic´ular. bile canaliculi fine tubular channels forming a three-dimensional network within the parenchyma of the liver. They ...
- Definition of CANALICULUS: a minute canal in a bodily structure — can · a · lic · u · lar \-lər\ adjective ADVERTISEMENT Origin of CANALICULUS Latin, diminutive of ... Medical Definition of CANALICULUS : a minute canal in a ...
Related Pictures
★リンクテーブル★
| リンク元 | 「tubule」「canalicular」「小管」「細管」「ductular」 |
| 拡張検索 | 「bile canaliculi」「biliary canaliculi」 |
「tubule」
- n.
「canalicular」
- n.
- 細管状の、管状腺、毛細胆管の
「小管」
「細管」
- 英
- canaliculus、canaliculi、tubule
- 関
- 小管、尿細管
「ductular」
- n.
- 小管の