凝固検査、凝固試験

WordNet

undergo a test; "She doesnt test well"
any standardized procedure for measuring sensitivity or memory or intelligence or aptitude or personality etc; "the test was standardized on a large sample of students" (同)mental test, mental testing, psychometric test
the act of undergoing testing; "he survived the great test of battle"; "candidates must compete in a trial of skill" (同)trial
the act of testing something; "in the experimental trials the amount of carbon was measured separately"; "he called each flip of the coin a new trial" (同)trial, run
a hard outer covering as of some amoebas and sea urchins
put to the test, as for its quality, or give experimental use to; "This approach has been tried with good results"; "Test this recipe" (同)prove, try, try out, examine, essay
achieve a certain score or rating on a test; "She tested high on the LSAT and was admitted to all the good law schools"
determine the presence or properties of (a substance)
show a certain characteristic when tested; "He tested positive for HIV"
an examination of the characteristics of something; "there are laboratories for commercial testing"; "it involved testing thousands of children for smallpox"
the act of subjecting to experimental test in order to determine how well something works; "they agreed to end the testing of atomic weapons"
tested and proved useful or correct; "a tested method" (同)tried, well-tried
tested and proved to be reliable (同)time-tested, tried, tried and true

PrepTutorEJDIC

(人の能力などの)『試験』,考査,テスト / (物事の)『試験』,検済,試錬,実験《+of+名》 / 化学分析;試薬 / =test match / …‘を'『試験する』,検査する / …‘を'化学分析する / (…の)試験を受ける,試験をする《+for+名》
凝固,凝結
testis の複数形

UpToDate Contents

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1. 凝固検査の臨床使用 clinical use of coagulation tests
2. 出血性素因を有する成人患者へのアプローチ approach to the adult patient with a bleeding diathesis
3. 出血症状を有する小児に対するアプローチ approach to the child with bleeding symptoms
4. 静脈血栓塞栓症の患者における理論的根拠と無期限の抗凝固の適応 rationale and indications for indefinite anticoagulation in patients with venous thromboembolism
5. 成人における確定診断を得られていない低血圧やショックの評価および初期アプローチ evaluation of and initial approach to the adult patient with undifferentiated hypotension and shock

English Journal

Hemocompatible surface of electrospun nanofibrous scaffolds by ATRP modification.

Yuan W, Feng Y, Wang H, Yang D, An B, Zhang W, Khan M, Guo J.SourceSchool of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
Materials science & engineering. C, Materials for biological applications.Mater Sci Eng C Mater Biol Appl.2013 Oct;33(7):3644-51. doi: 10.1016/j.msec.2013.04.048. Epub 2013 May 3.
The electrospun scaffolds are potential application in vascular tissue engineering since they can mimic the nano-sized dimension of natural extracellular matrix (ECM). We prepared a fibrous scaffold from polycarbonateurethane (PCU) by electrospinning technology. In order to improve the hydrophilicit
PMID 23910260

Spontaneous remission of acromegaly after infarctive apoplexy with a possible relation to MRI and diabetes mellitus.

[No authors listed]AbstractOBJECTIVES: Pituitary apoplexy is a rare clinical syndrome associated with rapid enlargement of a pituitary mass. We report the initial presentation, subsequent course and outcome of an acromegalic patient who developed spontaneous remission following pituitary apoplexy with pathologic findings of tumor infarction. Clinical Presentation: A 38 year-old man with typical acromegalic features was referred to our hospital. He had been diabetic and hypertensive. His basal GH and IGF-1 levels were high (80 µg/L and 747 ng/mL respectively). Sella MRI showed a macroadenoma about 19×20 mm in size. He admitted to emergency department with complains of severe frontal headache accompanied by nausea and vomiting two days after MRI was taken. His neurological examination and visual field test were normal. Emergent MRI of the sella disclosed an enhancing intrasellar mass of 24×23 mm compressing the optic chiasm. The patient underwent transsphenoidal decompression of the lesion. Histological examination revealed an adenomatous tissue showing nonhemorrhagic coagulation necrosis. Before surgery, his GH levels declined to 2.72 µg/L spontaneously and after surgery he was in remission even leading to a state of growth hormone deficiency. Conclusion: When apoplexy occurs in functionning adenomas, it may cause spontaneous remission. However pituitary apoplexy due to tumor infarction is very rare. Various precipitating factors have been reported in 25-30% of pituitary apoplexy patients. Diabetes mellitus and diabetic ketoacidosis are one of these. The presence of contrast media induced endothelial swelling with the result of hypoperfusion and diabetes mellitus associated vasculopathy might be a precipitating factor in this patient.
Neuro endocrinology letters.Neuro Endocrinol Lett.2013 Aug 7;34(5). [Epub ahead of print]
OBJECTIVES: Pituitary apoplexy is a rare clinical syndrome associated with rapid enlargement of a pituitary mass. We report the initial presentation, subsequent course and outcome of an acromegalic patient who developed spontaneous remission following pituitary apoplexy with pathologic findings of t
PMID 23922047

Serum Analysis of Coagulation Factors in IPF and NSIP.

Bargagli E, Madioni C, Bianchi N, Refini RM, Cappelli R, Rottoli P.SourceRespiratory Diseases Section, Department of Clinical Medicine and Immunological Sciences, Siena University, Policlinico S. Maria Le Scotte Viale M. Bracci 16, 53100, Siena, Italy, bargagli2@gmail.com.
Inflammation.Inflammation.2013 Aug 3. [Epub ahead of print]
Recent literature and our previous proteomic findings prompted us to study the coagulation system in idiopathic pulmonary fibrosis (IPF), the pathogenesis of which remains unclear. The aim of this study was to compare coagulation factors in idiopathic pulmonary fibrosis and idiopathic nonspecific in
PMID 23912648

Japanese Journal

急激に悪化した経過をたどり病理解剖で確定診断された肺動脈弁の孤発性感染性心内膜炎の1例

長田正史,長谷川浩,井上慎一郎,守屋佑貴子,輪千督高,須藤紀子,神崎恒一
日本老年医学会雑誌 51(5), 453-459, 2014
今回我々は，肺動脈弁に限局した感染性心内膜炎と確診された高齢女性の1例を経験した．症例は78歳女性．生来の日常生活動作は完全自立していた．2009年1月に一時的な悪寒を認めたが，自然軽快したため様子をみていた．2月7日再度悪寒が出現し，翌8日より食欲低下と左腰痛を認めた．嘔気と嘔吐も出現し，14日にトイレ歩行の際に下肢の脱力感を自覚した．その後会話や服薬も困難となり，体熱感と持続性の左腰痛が出現し …
NAID 130004713489

PT測定における検体保存の影響

桝谷亮太,田中秀磨,池本敏行,田窪孝行
医学検査 63(5), 535-544, 2014
… の理由として検体の低温保存によって起こる第VII因子のcold activationによりPTの測定秒数が短縮することが挙げられている2),3)．今回，検体の保存条件（温度と容器の種類）がPT，ヘパプラスチンテストhepaplastin test（HPT），トロンボテストthrombotest（TT）の測定秒数と凝固因子活性値に及ぼす影響を検討した．プラスチック容器保存の場合，室温，氷冷ともに検体採取直後に比べ8時間後のPTの測定秒数と第VII因子活性値に影 …
NAID 130004709165

A Case of Thrombophlebitis of the Internal Jugular Vein without Metastatic Abscess and Septic Emboli

Kuwata Fumihiko,Yamamoto Norio,Hiraumi Harukazu,Kishimoto Yo,Ito Juichi
耳鼻咽喉科臨床　補冊 140(0), 102-103, 2014
… Her laboratory test showed an elevated white blood cell count and elevated C-reactive protein (CRP), but the results of the test did not satisfy the criteria of disseminated intravascular coagulation. …
NAID 130004707406

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★リンクテーブル★

リンク元	「凝固能検査」「凝固試験」
関連記事	「testing」「test」

「凝固能検査」

　　[★]

英: coagulation test
同: 凝固試験; 血液凝固検査 blood coagulation test

[show details]

凝固能検査 : 約 24,600 件
凝固検査 : 約 14,900 件
血液凝固能検査 : 約 21,300 件
血液凝固検査 : 約 6,900 件
凝固能試験 : 16 件
凝固試験 : 約 1,280 件
血液凝固能試験 : 12 件
血液凝固試験 : 89 件

意義

凝固には血小板、凝固因子、Ca、ビタミンKが必要である。これらのどれかに異常が生じれば凝固は正常に行われない。従って凝固検査をおこなうことで、血小板数、凝固因子の量、Caの量、ビタミンKの量の異常を見つけることができる。凝固因子は肝臓で合成されるため、肝臓の機能低下によって凝固因子は減少し凝固系に異常を生じる。また、抗凝固薬のワーファリンはビタミンKに作用するため、投与量の管理はPT-INRを用いる。

方法

=PT

クエン酸Naの入ったスピッツに採血し、Caをちょうど凝固がおこらないだけキレートする。その血漿を組織トロンボプラスチンのついたビーズおよびCaを添加することで任意に凝固反応を開始し、凝固が完了すまでの時間を計る。

注意

凝固検査ではちょうど凝固がおこらないだけCaをキレートすることによって、検査時にCaを投与することで即座に凝固が開始される。そのためにはスピッツで血液とクエン酸Naが9:1の割合で混ざる必要がある。よって十分量の血液を採取することが重要である。INRはワーファリンの投与実験から導きだされた数値であるので、ワーファリンの管理以外に用いるのは不適である。