関: clobetasone butyrate

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/11/19 23:33:04」(JST)

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Clobetasone (INN^[1]) is a corticosteroid used in dermatology, for treating such skin inflammation as seen in eczema, psoriasis and other forms of dermatitis, and ophthalmology.

It is available as clobetasone butyrate under the brand name Eumovate^[2] or Trimovate,^[3] both manufactured by GlaxoSmithKline.

As Trimovate, it also contains Oxytetracycline, an antibiotic, and nystatin, an antifungal.^[4]^[5]

References[edit]

^ United Nations Statistics Division - Classifications Registry - Alphabetical index for HS 2002 Entries starting with 'C' (page 310 of 422)
^ Eumovate cream/ointment, NetDoctor.co.uk
^ Trimovate cream, NetDoctor.co.uk
^ 30g Trimovate Cream Box, GSK
^ Medicines.org.uk - Trimovate info

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1. 思春期および成人における脂漏性皮膚炎 seborrheic dermatitis in adolescents and adults
2. アトピー性角結膜炎 atopic keratoconjunctivitis

English Journal

Exogenous Cushing Syndrome due to Topical Clobetasone use for Diaper Rash.

Jevalikar G1, Sharma O.
Indian pediatrics.Indian Pediatr.2016 Jan 8;53(1):76-7.
PMID 26840685

Detection of glucocorticoid receptor agonists in effluents from sewage treatment plants in Japan.

Suzuki G1, Sato K2, Isobe T3, Takigami H4, Brouwer A5, Nakayama K2.
The Science of the total environment.Sci Total Environ.2015 Sep 15;527-528:328-34. doi: 10.1016/j.scitotenv.2015.05.008. Epub 2015 May 14.
Glucocorticoids (GCs) are widely used as anti-inflammatory drugs. Our previous study demonstrated that several GCs such as cortisol and dexamethasone (Dex) were frequently detected in effluents collected from Japanese sewage treatment plants (STPs) in 2012. In this study, we used the GC-Responsive C
PMID 25965047

Determination of natural and synthetic glucocorticoids in effluent of sewage treatment plants using ultrahigh performance liquid chromatography-tandem mass spectrometry.

Isobe T1, Sato K, Joon-Woo K, Tanabe S, Suzuki G, Nakayama K.
Environmental science and pollution research international.Environ Sci Pollut Res Int.2015 Sep;22(18):14127-35. doi: 10.1007/s11356-015-4626-0. Epub 2015 May 13.
A sensitive and comprehensive analytical method for glucocorticoids (GCs) in water samples was developed and applied to effluent of sewage treatment plants (STPs). In the present study, totally 10 natural and synthetic GCs, including cortisol, betamethasone valerate, clobetasol propionate, clobetaso
PMID 25963071

Japanese Journal

Magnetic Resonance Imaging of the Phase Separation in Mixed Preparations of Moisturizing Cream and Steroid Ointment after Centrifugation

Chemical and Pharmaceutical Bulletin 63(5), 377-383, 2015
NAID 130005067239

クロベタゾン酪酸エステル軟膏の製剤学的評価 : 先発品とジェネリック品との比較

製剤機械技術学会誌 = Journal of pharmaceutical machinery and engineering 23(4), 336-341, 2014
NAID 40020345548

Liquid chromatography-tandem mass spectrometric assay for clobetasol propionate in human serum from patients with atopic dermatitis

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 878(23), 2150-2154, 2010-08-01
NAID 10028039946

「クロベタゾン」

Clobetasone
Systematic (IUPAC) name
	(1R,2S,10S,11S,13S,14R,15S)-14-(2-chloroacetyl)-1-fluoro-14-hydroxy-2,13,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-diene-5,17-dione
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy cat.	?
Legal status	?
Routes	topical
Identifiers
CAS number	54063-32-0
ATC code	D07AB01 S01BA09
PubChem	CID 71387
ChemSpider	64482
UNII	LT69WY1J6D
KEGG	D07717
Synonyms	(8S,9R,10S,13S,14S,16S,17R)-17-(2-Chloroacetyl)-9-fluoro-17-hydroxy-10,13,16-trimethyl-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthrene-3,11-dione
Chemical data
Formula	C22H26ClFO4
Mol. mass	408.891
	SMILES ClCC(=O)[C@@]2(O)[C@@H](C)C[C@H]1[C@H]4[C@](F)(C(=O)C[C@@]12C)[C@@]/3(/C(=C\C(=O)\C=C\3)CC4)C;
	InChI InChI=1S/C22H26ClFO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,24)17(26)10-20(16,3)22(12,28)18(27)11-23/h6-7,9,12,15-16,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,19-,20-,21-,22-/m0/s1 ; Key:XXIFVOHLGBURIG-OZCCCYNHSA-N ;
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