WordNet
- lack of success; "he felt that his entire life had been a failure"; "that year there was a crop failure"
- loss of ability to function normally; "kidney failure"
- an act that fails; "his failure to pass the test"
- an unexpected omission; "he resented my failure to return his call"; "the mechanics failure to check the brakes"
- a person with a record of failing; someone who loses consistently (同)loser, nonstarter, unsuccessful person
- an event that does not accomplish its intended purpose; "the surprise party was a complete failure"
- being long-lasting and recurrent or characterized by long suffering; "chronic indigestion"; "a chronic shortage of funds"; "a chronic invalid"
- of long duration; "chronic money problems" (同)continuing
- habitual; "a chronic smoker" (同)inveterate
- pertaining to or affecting the liver; "hepatic ducts"; "hepatic cirrhosis"
PrepTutorEJDIC
- 〈U〉(…における)『失敗』,不成功《+『in』+『名』(do『ing』)》 / 〈C〉失敗者,落後者;失敗した企て,不できなもの / 〈U〉〈C〉怠慢,不履行 / 〈U〉〈C〉(…の)不足,欠乏《+『of』+『名』》 / 〈U〉〈C〉(…の)破産《+『of』+『名』》 / 〈U〉(…の)『衰弱』,減退《+『in』(『of』+『名』》
- (病気が)長期にわたる,慢性の / 《名詞の前にのみ用いて》常習の,癖になった
- 肝臓の;肝臓にきく,肝臓のような色の
UpToDate Contents
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- 1. Cirrhosis in adults: Etiologies, clinical manifestations, and diagnosis
- 2. 肝硬変の合併症、予後、およびマネージメントの概要 overview of the complications prognosis and management of cirrhosis
- 3. 肝硬変患者における腹水の治療：初期治療 ascites in adults with cirrhosis initial therapy
- 4. アルコール性脂肪性肝炎およびアルコール性肝硬変の臨床症状および診断 clinical manifestations and diagnosis of alcoholic fatty liver disease and alcoholic cirrhosis
- 5. アルコール性脂肪性肝疾患およびアルコール性肝硬変の予後および治療 prognosis and management of alcoholic fatty liver disease and alcoholic cirrhosis
English Journal
- The impact of obesity and metabolic syndrome on alcoholic liver disease.
- Chiang DJ, McCullough AJ.Author information Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, A51, 9500 Euclid Avenue, Cleveland, OH 44195, USA.AbstractAlcoholic liver disease (ALD) remains a major cause of chronic liver diseases and liver failure. Population-based prospective studies and patient cohort studies have demonstrated that obesity and the metabolic syndrome exacerbate progression of ALD and increase hepatocellular carcinoma (HCC) incidence and mortality. Emerging evidence also suggests a synergism between alcohol and obesity in mortality and HCC incidence. Recognition of these increased risks and detection of early-stage liver disease may offer the opportunity to address these modifiable risk factors and prevent disease progression in these patients.
- Clinics in liver disease.Clin Liver Dis.2014 Feb;18(1):157-63. doi: 10.1016/j.cld.2013.09.006. Epub 2013 Oct 24.
- Alcoholic liver disease (ALD) remains a major cause of chronic liver diseases and liver failure. Population-based prospective studies and patient cohort studies have demonstrated that obesity and the metabolic syndrome exacerbate progression of ALD and increase hepatocellular carcinoma (HCC) inciden
- PMID 24274871
- Predictive risk factors of venous thromboembolism in autologous breast reconstruction surgery.
- Masoomi H, Paydar KZ, Wirth GA, Aly A, Kobayashi MR, Evans GR.Author information From the Aesthetic and of Plastic Surgery Institute, University of California, Irvine Medical Center, Orange, CA.AbstractBACKGROUND: Venous thromboembolism (VTE) can be a significant cause of morbidity and mortality in autologous breast reconstruction surgery. The aim of this study was to evaluate the effect of patient characteristics, comorbidities, payer type, reconstruction type, reconstruction timing, radiation, chemotherapy, and teaching status of hospital on VTE (deep venous thrombosis and/or pulmonary embolism) in autologous breast reconstructive surgery.
- Annals of plastic surgery.Ann Plast Surg.2014 Jan;72(1):30-3. doi: 10.1097/SAP.0000000000000003.
- BACKGROUND: Venous thromboembolism (VTE) can be a significant cause of morbidity and mortality in autologous breast reconstruction surgery. The aim of this study was to evaluate the effect of patient characteristics, comorbidities, payer type, reconstruction type, reconstruction timing, radiation, c
- PMID 24317244
- Candidate gene polymorphisms in patients with acetaminophen-induced acute liver failure.
- Court MH, Peter I, Hazarika S, Vasiadi M, Greenblatt DJ, Lee WM; Acute Liver Failure Study Group.Author information Pharmacogenomics Laboratory, and Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington (M.H.C.); Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York (I.P.); Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, Massachusetts (S.H., D.J.G.); Program in Pharmacology and Experimental Therapeutics, Tufts University Sackler School of Graduate Biomedical Sciences, Boston, Massachusetts (M.V., D.J.G.); and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas (W.M.L.).AbstractAcetaminophen is a leading cause of acute liver failure (ALF). Genetic differences might predispose some individuals to develop ALF. In this exploratory study, we evaluated genotype frequency differences among patients enrolled by the ALF Study Group who had developed ALF either intentionally from a single-time-point overdose of acetaminophen (n = 78), unintentionally after chronic high doses of acetaminophen (n = 79), or from causes other than acetaminophen (n = 103). The polymorphisms evaluated included those in genes encoding putative acetaminophen-metabolizing enzymes (UGT1A1, UGT1A6, UGT1A9, UGT2B15, SULT1A1, CYP2E1, and CYP3A5) as well as CD44 and BHMT1. Individuals carrying the CYP3A5 rs776746 A allele were overrepresented among ALF patients who had intentionally overdosed with acetaminophen, with an odds ratio of 2.3 (95% confidence interval, 1.1-4.9; P = 0.034) compared with all other ALF patients. This finding is consistent with the enhanced bioactivation of acetaminophen by the CYP3A5 enzyme. Persons homozygous for the CD44 rs1467558 A allele were also overrepresented among patients who had unintentionally developed ALF from chronic acetaminophen use, with an odds ratio of 4.0 (1.0-17.2, P = 0.045) compared with all other ALF subjects. This finding confirms a prior study that found elevated serum liver enzyme levels in healthy volunteers with the CD44 rs1467558 AA genotype who had consumed high doses of acetaminophen for up to 2 weeks. However, both genetic associations were considered relatively weak, and they were not statistically significant after adjustment for multiple comparisons testing. Nevertheless, both CYP3A5 rs776746 and CD44 rs1467558 warrant further investigation as potential genomic markers of enhanced risk of acetaminophen-induced ALF.
- Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2014 Jan;42(1):28-32. doi: 10.1124/dmd.113.053546. Epub 2013 Oct 8.
- Acetaminophen is a leading cause of acute liver failure (ALF). Genetic differences might predispose some individuals to develop ALF. In this exploratory study, we evaluated genotype frequency differences among patients enrolled by the ALF Study Group who had developed ALF either intentionally from a
- PMID 24104197
Japanese Journal
- Mesenchymal stem cell therapy on murine model of nonalcoholic steatohepatitis
- Sakai Yoshio,Kaneko Shuichi
- Methods in Molecular Biology 826, 217-223, 2012
- … A severely malfunctioning liver, due to acute liver injury or chronic liver disease, can lead to hepatic failure. … The ultimate treatment for hepatic failure is liver transplantation; …
- NAID 120003989047
- 慢性活動性EBウイルス感染症関連の亜広範肝壊死の1例
- 樋上 勝也,石井 耕司,澤 美里,篠原 美絵,渡邉 学,田村 晃,中島 早苗,渋谷 和俊,倉持 茂,住野 泰清
- 肝臓 51(12), 706-713, 2010-12-25
- 症例は65歳男性，慢性腎不全で加療されていた．2008年4月に原因不明の肝障害が出現し当科紹介，原因検索したが不明のまま血清AST，ALTは自然軽快した．9月に再び肝障害が増悪した際，EBV-VCA IgG抗体価が高値で，ISH法とPCR法により血中，肝組織内のEBV-DNAを確認したことから，慢性活動性EBウイルス感染症（CAEBV）と診断．強力ミノファーゲンC 60 ml /日投与により肝障害 …
- NAID 10027661677
Related Links
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★リンクテーブル★
| リンク元 | 「慢性肝不全」「chronic liver failure」 |
| 関連記事 | 「failure」「chronic」「hepatic」 |
「慢性肝不全」
「chronic liver failure」
「failure」
- n.
- 失敗、不首尾
- 失敗して企て、不出来なもの、失敗者。(教育)落第、落第点
- 怠慢、不履行(to do)。支払い不能、破産、倒産
- 無いこと。不十分、不足
- (力などの)減退。(医)機能不全。故障。(機)破壊、破損
「chronic」
- adj.
- 慢性の、慢性的な、慢性型の
「hepatic」
- adj.
- 肝臓の、肝性の、肝の