関: central gray matter

WordNet

in or near a center or constituting a center; the inner area; "a central position"
a workplace that serves as a telecommunications facility where lines from telephones can be connected together to permit communication (同)telephone exchange, exchange
United States botanist who specialized in North American flora and who was an early supporter of Darwins theories of evolution (1810-1888) (同)Asa Gray
English radiobiologist in whose honor the gray (the SI unit of energy for the absorbed dose of radiation) was named (1905-1965) (同)Louis Harold Gray
American navigator who twice circumnavigated the globe and who discovered the Columbia River (1755-1806) (同)Robert Gray
English poet best known for his elegy written in a country churchyard (1716-1771) (同)Thomas Gray
the SI unit of energy absorbed from ionizing radiation; equal to the absorption of one joule of radiation energy by one kilogram of matter; one gray equals 100 rad (同)Gy
a neutral achromatic color midway between white and black (同)grayness, grey, greyness

PrepTutorEJDIC

『中心の』,中央の,中心からの / 『主要な』,中心的な(main) / (音声が)中舌音の / 電話交換局(《英》[telephone]exchange)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/24 11:07:58」(JST)

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The periaqueductal gray (PAG) (also known as the central gray) is the primary control center for descending pain modulation. It has enkephalin-producing cells that suppress pain.

The periaqueductal grey is the grey matter located around the cerebral aqueduct within the tegmentum of the midbrain. It projects to the nucleus raphe magnus, and also contains descending autonomic tracts. The ascending pain and temperature fibers of the spinothalamic tract send information to the PAG via the spinomesencephalic tract (so-named because the fibers originate in the spine and terminate in the PAG, in the mesencephalon or midbrain).

This region has been used as the target for brain-stimulating implants in patients with chronic pain.

Role in analgesia

Stimulation of the periaqueductal gray matter of the midbrain activates enkephalin-releasing neurons that project to the raphe nuclei in the brainstem. 5-HT (serotonin) released from the raphe nuclei descends to the dorsal horn of the spinal cord where it forms excitatory connections with the "inhibitory interneurons" located in Laminae II (aka the substantia gelatinosa). When activated, these interneurons release either enkephalin or dynorphin (endogenous opioid neurotransmitters), which bind to mu opioid receptors on the axons of incoming C and A-delta fibers carrying pain signals from nociceptors activated in the periphery. The activation of the mu-opioid receptor inhibits the release of substance P from these incoming first-order neurons and, in turn, inhibits the activation of the second-order neuron that is responsible for transmitting the pain signal up the spinothalamic tract to the ventroposteriolateral nucleus (VPL) of the thalamus. The nociceptive signal was inhibited before it was able to reach the cortical areas that interpret the signal as "pain" (such as the anterior cingulate). This is sometimes referred to as the Gate control theory of pain and is supported by the fact that electrical stimulation of the PAG results in immediate and profound analgesia.^[1] The periaqueductal gray is also activated by viewing distressing images associated with pain.^[2]

Three known kinds of opioid receptors have been identified: mu (μ), kappa (κ) and delta (δ). Synthetic opioid and opioid-derivative drugs activate these receptors (possibly by acting on the PAG directly, where these receptors are densely expressed) to produce analgesia. These drugs include morphine, heroin (diacetylmorphine), pethidine, hydrocodone, oxycodone, and similar pain-reducing compounds.

Role in defensive behavior

Stimulation of the dorsal and lateral aspects of the PAG (in the rat) can provoke defensive responses characterised by freezing immobility, running, jumping, tachycardia, and increases in blood pressure and muscle tonus. In contrast, stimulation of the caudal ventrolateral PAG can result in an immobile, relaxed posture known as quiescence, whereas its inhibition leads to increased locomotor activity.

Lesions of the caudal ventrolateral PAG can greatly reduce conditioned freezing, whereas lesions of the dorsal aspect can reduce innate defensive behavior, virtually "taming" the animal.

Role in reproductive behavior

Neurons of the PAG are excited by endorphins and by opiate analgesics. It also plays a role in female copulatory behavior (see Lordosis behavior) via a pathway from the ventromedial nucleus of the hypothalamus.

Role in maternal behavior

The PAG may be specifically involved in human maternal behavior. The PAG contains a high density of vasopressin and oxytocin receptors, and it has direct connections with the orbitofrontal cortex, which might mediate the role of the PAG in maternal love. The lateral orbitofrontal cortex is activated by pleasant visual, tactile, and olfactory stimuli. Its response depends on pleasantness rather than on intensity of stimulation. Here, its activity is likely to reflect one aspect of the pleasant emotions associated with motherly love.^[3]

Role in consciousness

If there is a lesion in the PAG, then consciousness is lost. This observation does not mean that the PAG, itself, is the center of consciousness, but rather that it is a critically needed part of it.^[4]^[5]

Additional images

Schematic representation of the chief ganglionic categories (I to V).
Transverse section of mid-brain at level of inferior colliculi.
Transverse section of mid-brain at level of superior colliculi.
MRI section of human mid-brain showing periaqueductal gray

References

^ Basbaum AI, Fields HL (November 1978). "Endogenous pain control mechanisms: review and hypothesis". Ann. Neurol. 4 (5): 451–62. doi:10.1002/ana.410040511. PMID 216303.
^ Jenkins, Dacher Keltner, Keith Oatley, Jennifer M. Understanding emotions (3rd ed.). Hoboken, N.J.: Wiley. ISBN 9781118147436.
^ Andreas Bartels and Semir Zeki (March 2004). "The neural correlates of maternal and romantic love" (PDF). NeuroImage 21 (3): 1155–1166. doi:10.1016/j.neuroimage.2003.11.003. PMID 15006682.
^ Patricia Churchland (Video) (2009), Consciousness panel of The Science Network (min. 26)
^ Watt D.FT (2000), "The centrecephalon and thalamocortical integration: Neglected contributions of periaqueductal gray".

External links

Stained brain slice images which include the "Periaqueductal gray" at the BrainMaps project

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Related Pictures

★リンクテーブル★

拡張検索	「midbrain central gray」「spinal central gray」
関連記事	「central」「gray」

「midbrain central gray」

Periaqueductal grey
	Section through superior colliculus showing path of oculomotor nerve. Periaqueductal gray is the gray area just peripheral to the cerebral aqueduct.
	Coronal section through mid-brain.; 1. Corpora quadrigemina.; 2. Cerebral aqueduct.; 3. Central gray stratum.; 4. Interpeduncular space.; 5. Sulcus lateralis.; 6. Substantia nigra.; 7. Red nucleus of tegmentum.; 8. Oculomotor nerve, with 8’, its nucleus of origin. a. Lemniscus (in blue) with a’ the medial lemniscus and a" the lateral lemniscus. b. Medial longitudinal fasciculus. c. Raphé. d. Temporopontine fibers. e. Portion of medial lemniscus, which runs to the lentiform nucleus and insula. f. Cerebrospinal fibers. g. Frontopontine fibers.
Details
Latin	Subtstantia grisea centralis
Identifiers
Gray's	p.806
MeSH	A08.186.211.132.659.822.595
NeuroNames	hier-501
NeuroLex ID	Periaqueductal gray
Dorlands; /Elsevier	s_27/12766787
TA	A14.1.06.321
FMA	83134
	Anatomical terms of neuroanatomy

　　[★]

中脳中心灰白質

関: periaqueductal gray

「spinal central gray」

　　[★]

同: 脊髄灰白質中心部

「central」

　　[★]

adj.

中心の、中心的な、中心性の、中枢的な、中枢性の、中枢の、中枢神経性の

関: center、centrally、centrally acting、centre、centro、centrum、hub、medial、pivotal、pivotally

「gray」

　　[★]

n.

グレー、灰色、灰白、(放射線の吸収線量単位)グレイ

関: grey、griseus、Gy

[1] Basbaum AI, Fields HL (November 1978). "Endogenous pain control mechanisms: review and hypothesis". Ann. Neurol. 4 (5): 451–62. doi:10.1002/ana.410040511. PMID 216303.

[2] Jenkins, Dacher Keltner, Keith Oatley, Jennifer M. Understanding emotions (3rd ed.). Hoboken, N.J.: Wiley. ISBN 9781118147436.

[3] Andreas Bartels and Semir Zeki (March 2004). "The neural correlates of maternal and romantic love" (PDF). NeuroImage 21 (3): 1155–1166. doi:10.1016/j.neuroimage.2003.11.003. PMID 15006682.

[TSN_Consciousness-4] Patricia Churchland (Video) (2009), Consciousness panel of The Science Network (min. 26)

[kdkdk-5] Watt D.FT (2000), "The centrecephalon and thalamocortical integration: Neglected contributions of periaqueductal gray".

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案内

central gray