WordNet
- small room in which a monk or nun lives (同)cubicle
- a device that delivers an electric current as the result of a chemical reaction (同)electric cell
- a room where a prisoner is kept (同)jail cell, prison cell
- (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
- any small compartment; "the cells of a honeycomb"
- a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
- the descendants of one individual; "his entire lineage has been warriors" (同)line, line of descent, descent, bloodline, blood_line, blood, pedigree, ancestry, origin, parentage, stemma, stock
PrepTutorEJDIC
- (刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
- 血統,家系 / 《集合的に》子孫,一族
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/05/26 02:57:45」(JST)
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General stages of cell linage (cell lineage of liver development in red)
Cell lineage denotes the developmental history of a tissue or organ from the fertilized embryo.[1] Cell lineage can be studied by marking a cell (with fluorescent molecules or other traceable markers) and following its progeny after cell division. Some organisms such as C. elegans have a predetermined pattern of cell progeny and the adult male will always consist of 1031 cells, this is because cell division in C. elegans is genetically determined and known as eutely.[2][3] This causes the cell lineage and cell fate to be highly correlated. Other organisms, such as humans, have variable lineages and somatic cell numbers.
Contents
- 1 C. elegans: Model Organism
- 2 History of Cell Lineage
- 3 Techniques of Fate Mapping
- 4 References
C. elegans: Model Organism
As one of the first pioneers of cell lineage, in the 1960s Dr. Sydney Brenner first began observing cell differentiation and succession in the nematode Caenorhabditis elegans. Dr. Brenner chose this organism due to its transparent body, quick reproduction, ease of access, and small size which made it ideal for following cell lineage under a microscope.
By 1976, Dr. Brenner and his associate, Dr. John Sulston, had identified part of the cell lineage in the developing nervous system of C. elegans. Recurring results showed that the nematode was eutelic (each individual experiences the same differentiation pathways). This research led to the initial observations of programmed cell death, or apoptosis.
After mapping various sections of the C. elegans' cell lineage, Dr. Brenner and his associates were able to piece together the first complete and reproducible fate map of cell lineage. They later received the 2002 Nobel prize for their work in genetic regulation of organ development and programmed cell death. [4]
History of Cell Lineage
One of the first studies of cell lineages took place in the 1870s by Whitman who studied cleavage patterns in leeches and small invertebrates.[5] He found that some groups, such as nematode worms and ascidians form a pattern of cell division which is identical between individuals and invariable. This high correlation between cell lineage and cell fate was thought to be determined by segregating factors within the dividing cells. Other organisms had stereotyped patterns of cell division and produced sublineages which were the progeny of particular precursor cells. These more variable cell fates are thought to be due to the cells' interaction with the environment.[5]
Techniques of Fate Mapping
Cell lineage can be determined by two methods, either through direct observation or through clonal analysis. During the early 19th century direct observation was used however it was highly limiting as only small transparent samples could be studied. With the invention of the confocal microscope this allowed larger more complicated organisms to be studied.[5]
References
- ^ Collins English Dictionary - Complete & Unabridged 10th Edition. HarperCollins Publishers. Retrieved 2 June 2014.
- ^ Sulston, JE; Horvitz, HR (1977). "Post-embryonic cell lineages of the nematode, Caenorhabditis elegans". Developmental Biology 56 (1): 110–56. doi:10.1016/0012-1606(77)90158-0. PMID 838129.
- ^ Kimble, J; Hirsh, D (1979). "The postembryonic cell lineages of the hermaphrodite and male gonads in Caenorhabditis elegans". Developmental Biology 70 (2): 396–417. doi:10.1016/0012-1606(79)90035-6. PMID 478167.
- ^ "The Nobel Prize in Physiology or Medicine for 2002 - Press Release". www.nobelprize.org. Retrieved 2015-11-23.
- ^ a b c Chisholm, A D (2001). "Cell Lineage" (PDF). Academic Press: 10. doi:10.1006/rwgn.2001.0172.
UpToDate Contents
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English Journal
- Complement C3 of the innate immune system secreted by muscle adipogenic cells promotes myogenic differentiation.
- Rouaud T1, Siami N1, Dupas T1, Gervier P1, Gardahaut MF1, Auda-Boucher G2, Thiriet C3.
- Scientific reports.Sci Rep.2017 Dec;7(1):171. doi: 10.1038/s41598-017-00099-7. Epub 2017 Mar 13.
- PMID 28279023
- Impact of Cryopreservation on Caprine Fetal Adnexa Derived Stem Cells and Its Evaluation for Growth Kinetics, Phenotypic Characterization, and Wound Healing Potential in Xenogenic Rat Model.
- Somal A1, Bhat IA1, B I1, Singh AP2, Panda BSK1, Desingu PA3, Pandey S1, Bharti MK1, Pal A2, Saikumar G3, Chandra V1, Sharma GT1.
- Journal of cellular physiology.J Cell Physiol.2017 Aug;232(8):2186-2200. doi: 10.1002/jcp.25731. Epub 2017 Mar 1.
- PMID 27966782
- Osteogenic differentiation of human gingival mesenchymal stem cells by Aristolochia bracteolata supplementation through enhanced Runx2 expression.
- Murugan Girija D1, Y Ranga Rao S2, Kalachaveedu M3, Subbarayan R4.
- Journal of cellular physiology.J Cell Physiol.2017 Jul;232(7):1591-1595. doi: 10.1002/jcp.25835. Epub 2017 Feb 21.
- PMID 28150858
Japanese Journal
- PDGF-induced proliferation and differentiation of synovial mesenchymal stem cells is mediated by the PI3K-PKB / Akt pathway
- Generation of TCR-Expressing Innate Lymphoid-like Helper Cells that Induce Cytotoxic T Cell-Mediated Anti-leukemic Cell Response
- レコンビナーゼCreERT2導入BACクローンによって作製したトランスジェニックラットの組織化学・細胞生物学的研究
Related Links
- cell lineageとは。意味や和訳。セル・リネージ,細胞系譜:受精卵の割球や,血球細胞などが発生分化していく一連の過程で,細胞がどの細胞から分化するのかを系統立てたもの. - 40万項目以上収録、例文・コロケーションが豊富な無料 ...
- cell lineage 細胞系統[系譜] - アルクがお届けする進化するオンライン英和・和英辞書データベース。一般的な単語や連語から、イディオム、専門用語、スラングまで幅広く収録。
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★リンクテーブル★
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- cell lineage
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- 細胞系譜
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- cell lineage
- 関
- 細胞系列
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- blood line、descent、line、paradigmatic、pedigree、sequential、serial、series、stock、strain
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細胞