WordNet

an abundant nonmetallic tetravalent element occurring in three allotropic forms: amorphous carbon and graphite and diamond; occurs in all organic compounds (同)C, atomic number 6
a copy made with carbon paper (同)carbon_copy
the 9th letter of the Roman alphabet (同)i

PrepTutorEJDIC

『炭素』(化学記号は『C』) / 〈C〉炭素棒 / 〈C〉《時に〈U〉》=carbon paper
『私は』私が
iodineの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/10/29 22:22:40」(JST)

wiki en

Carbonic anhydrase 3 is an enzyme that in humans is encoded by the CA3 gene.^[1]

Carbonic anhydrase III (CAIII) is a member of a multigene family (at least six separate genes are known) that encode carbonic anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible hydration of carbon dioxide and are differentially expressed in a number of cell types. The expression of the CA3 gene is strictly tissue-specific and present at high levels in skeletal muscle and much lower levels in cardiac and smooth muscle. A proportion of carriers of Duchenne muscle dystrophy have a higher CA3 level than normal. The gene spans 10.3 kb and contains seven exons and six introns.^[2]

References

^ Shima K, Tashiro K, Hibi N, Tsukada Y, Hirai H (Jun 1983). "Carbonic anhydrase-III immunohistochemical localization in human skeletal muscle". Acta Neuropathol 59 (3): 237–9. doi:10.1007/BF00703210. PMID 6221502.
^ "Entrez Gene: CA3 carbonic anhydrase III, muscle specific". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=761.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 利尿剤の作用機序 mechanism of action of diuretics
2. 尿細管性アシドーシスにおける腎結石症 nephrolithiasis in renal tubular acidosis
3. 幼児および小児における尿細管性アシドーシスの病因および臨床症状 etiology and clinical manifestations of renal tubular acidosis in infants and children
4. 代謝性アルカローシスの治療 treatment of metabolic alkalosis
5. 腎尿細管性アシドーシスの概要と病態生理、およびカリウムバランスへの影響 overview and pathophysiology of renal tubular acidosis and the effect on potassium balance

English Journal

Novel application of acetazolamide to reduce cerebrospinal fluid production in patients undergoing thoracoabdominal aortic surgery.

Jafarzadeh F, Field ML, Harrington DK, Kuduvalli M, Oo A, Kendall J, Desmond M, Mills K.Author information Institute of Cardiovascular Medicine and Science, Thoracic Aortic Aneurysm Service, Liverpool Heart and Chest Hospital, Liverpool, UK.AbstractOBJECTIVES: Paraplegia is a rare but devastating complication, which may follow thoracoabdominal aortic surgery. Many adjuncts have been developed to reduce this risk including cerebrospinal fluid (CSF) drainage. Acetazolamide (carbonic anhydrase inhibitor) is a drug used to counteract mountain sickness and one of its effects is to reduce CSF production. Here, we report its first postoperative application in thoracoabdominal surgery with the aim of reducing cerebrospinal cord perfusion pressure and reducing risk of paraplegia.
Interactive cardiovascular and thoracic surgery.Interact Cardiovasc Thorac Surg.2014 Jan;18(1):21-6. doi: 10.1093/icvts/ivt384. Epub 2013 Oct 14.
OBJECTIVES: Paraplegia is a rare but devastating complication, which may follow thoracoabdominal aortic surgery. Many adjuncts have been developed to reduce this risk including cerebrospinal fluid (CSF) drainage. Acetazolamide (carbonic anhydrase inhibitor) is a drug used to counteract mountain sick
PMID 24130087

Proteomic identification of gravitropic response genes in peanut gynophores.

Li HF, Zhu FH, Li HY, Zhu W, Chen XP, Hong YB, Liu HY, Wu H, Liang XQ.Author information Crops Research Institute, Guangdong Academy of Agricultural Sciences, Wushan 510640, Guangzhou, China. Electronic address: 565340390@163.com.AbstractPeanut (Arachis hypogaea L.) is one of the most important oil-bearing crops in the world. The gravitropic response of peanut gynophores plays an essential role in peanut reproductive development. In this study, we developed an in vitro culture system and applied it to the study of peanut gynophore gravitropism. By comparing the proteomes of gynophores grown in vitro with the tip pointing upward (gravity stimulation sample) and downward (natural growth control) at 6h and 12h, we observed 42 and 39 with significantly altered expression pattern at 6 and 12h, respectively. Out of these proteins, 13 proteins showed same expression profiling at both 6h and 12h. They were identified by MALDI-TOF/TOF and further characterized with quantitative real time RT-PCR. Among the 13 identified proteins, two were identified as class III acidic endochitinases, two were identified as Kunitz trypsin protease inhibitors, and the remaining proteins were identified as pathogenesis-related class 10 protein, Ara h 8 allergen isoform 3, voltage-dependent anion channel, gamma carbonic anhydrase 1, germin-like protein subfamily 3 member 3 precursor, chloride channel, glycine-rich RNA-binding protein and gibberellin receptor GID1. Real time RT-PCR analysis revealed that transcriptional regulation is consistent with expression at the protein level for class III acidic endochitinase, Kunitz trypsin protease inhibitor, chloride channel and pathogenesis-related class 10 protein, while the expression of the other 7 proteins might be regulated at post-transcriptional levels. This study identified several potential gravitropic response proteins in peanut gynophores and helps to understand early gravitropic responses in peanut gynophores.
Journal of proteomics.J Proteomics.2013 Nov 20;93:303-13. doi: 10.1016/j.jprot.2013.08.006. Epub 2013 Aug 28.
Peanut (Arachis hypogaea L.) is one of the most important oil-bearing crops in the world. The gravitropic response of peanut gynophores plays an essential role in peanut reproductive development. In this study, we developed an in vitro culture system and applied it to the study of peanut gynophore g
PMID 23994445

Inhibition of human carbonic anhydrase isoforms I-XIV with sulfonamides incorporating fluorine and 1,3,5-triazine moieties.

Ceruso M, Vullo D, Scozzafava A, Supuran CT.Author information Università degli Studi di Firenze, Polo Scientifico, Laboratorio di Chimica Bioinorganica, Rm. 188, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy.AbstractReaction of cyanuryl fluoride with sulfanilamide or 4-aminoethylbenzenesulfonamide afforded triazinyl-substituted benzenesulfonamides incorporating fluorine, which were further derivatized by reaction with amines, amino alcohols, amino acids or amino acid esters. Inhibition studies of all the human (h) carbonic anhydrase (CA, EC 4.2.1.1) isoforms, hCA I-XIV with these compounds revealed that they show moderate-weak inhibition of hCA III, IV, VA and XIII, rather moderate inhibition against hCA I, VI, and IX, and excellent inhibition of the physiologically relevant hCA II, VII and XII. The inhibition profile of these fluorine containing triazinyl sulfonamides is thus very different from the corresponding analogs incorporating chlorine, which were previously investigated as inhibitors of some of these enzymes.
Bioorganic & medicinal chemistry.Bioorg Med Chem.2013 Nov 15;21(22):6929-36. doi: 10.1016/j.bmc.2013.09.031. Epub 2013 Sep 19.
Reaction of cyanuryl fluoride with sulfanilamide or 4-aminoethylbenzenesulfonamide afforded triazinyl-substituted benzenesulfonamides incorporating fluorine, which were further derivatized by reaction with amines, amino alcohols, amino acids or amino acid esters. Inhibition studies of all the human
PMID 24103430

Japanese Journal

亜鉛酵素の錯体化学的研究

YAKUGAKU ZASSHI 134(11), 1109-1124, 2014
NAID 130004712971

Early changes in proteome levels upon acute deltamethrin exposure in mammalian skin system associated with its neoplastic transformation potential

Journal of toxicological sciences 38(4), 629-642, 2013-08-01
NAID 10031178705

Bacillus thuringiensis Cry Toxins Bound Specifically to Various Proteins via Domain III, Which Had a Galactose-Binding Domain-Like Fold

Bioscience, biotechnology, and biochemistry 75(2), 305-312, 2011-02-23
NAID 10027897803

「炭酸脱水酵素III」

Carbonic anhydrase III, muscle specific
	; PDB rendering based on 1flj.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1Z93, 1Z97, 2HFW, 3UYN, 3UYQ
Identifiers
Symbols	CA3; CAIII; Car3
External IDs	OMIM: 114750 MGI: 88270 HomoloGene: 31298 ChEMBL: 2885 GeneCards: CA3 Gene
EC number	4.2.1.1
Gene Ontology
Molecular function	• carbonate dehydratase activity; • zinc ion binding; • nickel cation binding;
Cellular component	• cytosol;
Biological process	• one-carbon metabolic process; • response to oxidative stress; • bicarbonate transport; • small molecule metabolic process;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	This box: view; talk; edit;