carbonic anhydrase I

炭酸脱水酵素I

• (赤血球の細胞質に多いサブタイプ)炭酸脱水酵素I

WordNet

1. an abundant nonmetallic tetravalent element occurring in three allotropic forms: amorphous carbon and graphite and diamond; occurs in all organic compounds (同)C, atomic number 6
2. a copy made with carbon paper (同)carbon_copy
3. the 9th letter of the Roman alphabet (同)i

PrepTutorEJDIC

1. 『炭素』(化学記号は『C』) / 〈C〉炭素棒 / 〈C〉《時に〈U〉》=carbon paper
2. 『私は』私が
3. iodineの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/12/03 20:17:38」(JST)

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Carbonic anhydrase I
PDB rendering based on 1azm.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1AZM, 1BZM, 1CRM, 1CZM, 1HCB, 1HUG, 1HUH, 1J9W, 1JV0, 2CAB, 2FOY, 2FW4, 2IT4, 2NMX, 2NN1, 2NN7, 3LXE
Identifiers
Symbols	CA1; CA-I; CAB; Car1
External IDs	OMIM: 114800 MGI: 88268 HomoloGene: 20414 ChEMBL: 261 GeneCards: CA1 Gene
EC number	4.2.1.1
Gene Ontology Molecular function • carbonate dehydratase activity • zinc ion binding Cellular component • cytoplasm • Golgi apparatus • cytosol Biological process • one-carbon metabolic process • bicarbonate transport • small molecule metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	759	12346
Ensembl	ENSG00000133742	ENSMUSG00000027556
UniProt	P00915	P13634
RefSeq (mRNA)	NM_001128829.2	NM_001083957.1
RefSeq (protein)	NP_001122301.1	NP_001077426.1
Location (UCSC)	Chr 8: 86.24 – 86.29 Mb	Chr 3: 14.77 – 14.78 Mb
PubMed search	[1]	[2]

Carbonic anhydrase 1 is an enzyme that in humans is encoded by the CA1 gene.

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including cellular respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid.

They show extensive diversity in tissue distribution and in their subcellular localization. CA1 is closely linked to CA2 and CA3 genes on chromosome 8, and it encodes a cytosolic protein which is found at the highest level in erythrocytes. Transcript variants of CA1 utilizing alternative polyA_sites have been described in literature.

References

Further reading

• Tashian RE, Carter ND (1977). "Biochemical genetics of carbonic anhydrase.". Adv. Hum. Genet. 7: 1–56. PMID 827930.
• Sly WS, Hu PY (1995). "Human carbonic anhydrases and carbonic anhydrase deficiencies.". Annu. Rev. Biochem. 64 (1): 375–401. doi:10.1146/annurev.bi.64.070195.002111. PMID 7574487.
• Kendall AG, Tashian RE (1977). "Erythrocyte carbonic anhydrase I: inherited deficiency in humans.". Science 197 (4302): 471–2. doi:10.1126/science.406674. PMID 406674.
• Kannan KK, Notstrand B, Fridborg K, et al. (1975). "Crystal structure of human erythrocyte carbonic anhydrase B. Three-dimensional structure at a nominal 2.2-A resolution.". Proc. Natl. Acad. Sci. U.S.A. 72 (1): 51–5. doi:10.1073/pnas.72.1.51. PMC 432238. PMID 804171. //www.ncbi.nlm.nih.gov/pmc/articles/PMC432238/.
• Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin.". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
• Lowe N, Brady HJ, Barlow JH, et al. (1990). "Structure and methylation patterns of the gene encoding human carbonic anhydrase I.". Gene 93 (2): 277–83. doi:10.1016/0378-1119(90)90236-K. PMID 2121614.
• Noda Y, Sumitomo S, Hikosaka N, Mori M (1986). "Immunohistochemical observations on carbonic anhydrase I and II in human salivary glands and submandibular obstructive adenitis.". J. Oral Pathol. 15 (4): 187–90. doi:10.1111/j.1600-0714.1986.tb00604.x. PMID 3088232.
• Barlow JH, Lowe N, Edwards YH, Butterworth PH (1987). "Human carbonic anhydrase I cDNA.". Nucleic Acids Res. 15 (5): 2386. doi:10.1093/nar/15.5.2386. PMC 340641. PMID 3104879. //www.ncbi.nlm.nih.gov/pmc/articles/PMC340641/.
• Edwards YH, Barlow JH, Konialis CP, et al. (1988). "Assignment of the gene determining human carbonic anhydrase, CAI, to chromosome 8.". Ann. Hum. Genet. 50 (Pt 2): 123–9. doi:10.1111/j.1469-1809.1986.tb01030.x. PMID 3124707.
• Lin KT, Deutsch HF (1974). "Human carbonic anhydrases. XII. The complete primary structure of the C isozyme.". J. Biol. Chem. 249 (8): 2329–37. PMID 4207120.
• Giraud N, Marriq C, Laurent-Tabusse G (1975). "[Primary structure of human B erythrocyte carbonic anhydrase. 3. Sequence of CNBr fragment I and III (residues 149-260)]". Biochimie 56 (8): 1031–43. doi:10.1016/S0300-9084(74)80093-3. PMID 4217196.
• Andersson B, Nyman PO, Strid L (1972). "Amino acid sequence of human erythrocyte carbonic anhydrase B.". Biochem. Biophys. Res. Commun. 48 (3): 670–7. doi:10.1016/0006-291X(72)90400-7. PMID 4625868.
• Lin KT, Deutsch HF (1973). "Human carbonic anhydrases. XI. The complete primary structure of carbonic anhydrase B.". J. Biol. Chem. 248 (6): 1885–93. PMID 4632246.
• Omoto K, Ueda S, Goriki K, et al. (1981). "Population genetic studies of the Philippine Negritos. III. Identification of the carbonic anhydrase-1 variant with CA1 Guam.". Am. J. Hum. Genet. 33 (1): 105–11. PMC 1684865. PMID 6781336. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1684865/.
• Chegwidden WR, Wagner LE, Venta PJ, et al. (1995). "Marked zinc activation of ester hydrolysis by a mutation, 67-His (CAT) to Arg (CGT), in the active site of human carbonic anhydrase I.". Hum. Mutat. 4 (4): 294–6. doi:10.1002/humu.1380040411. PMID 7866410.
• Bekku S, Mochizuki H, Takayama E, et al. (1999). "Carbonic anhydrase I and II as a differentiation marker of human and rat colonic enterocytes.". Research in experimental medicine. Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie 198 (4): 175–85. PMID 9879596.
• Puscas I, Coltau M, Baican M, et al. (2001). "Vasoconstrictive drugs increase carbonic anhydrase I in vascular smooth muscle while vasodilating drugs reduce the activity of this isozyme by a direct mechanism of action.". Drugs under experimental and clinical research 27 (2): 53–60. PMID 11392054.

UpToDate Contents

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English Journal

• A proteomic study of protein variation between osteopenic and age-matched control bone tissue.

• Chaput CD, Dangott LJ, Rahm MD, Hitt KD, Stewart DS, Wayne Sampson H.SourceDepartment of Orthopedic Surgery, Scott & White Clinic.
• Experimental biology and medicine (Maywood, N.J.).Exp Biol Med (Maywood).2012 May 1;237(5):491-8. Epub 2012 May 22.
• The focus of this study was to identify changes in protein expression within the bone tissue environment between osteopenic and control bone tissue of human femoral neck patients with osteoarthritis. Femoral necks were compared from osteopenic patients and age-matched controls. A new method of bone
• PMID 22619369

• In vitro effects of some anabolic compounds on erythrocyte carbonic anhydrase I and II.

• Gençer N, Ergün A, Demir D.SourceChemistry Department/Biochemistry Div., Balikesir University, Cagis Kampus, Balikesir 10145, Turkey. ngencer@balikesir.edu.tr
• Journal of enzyme inhibition and medicinal chemistry.J Enzyme Inhib Med Chem.2012 Apr;27(2):208-10. Epub 2011 Jun 3.
• The in vitro effects of the anabolic compounds, zeranol, 17 β-estradiol, diethylstilbestrol (DES), and trenbolone, on the activity of purified human carbonic anhydrase I and II were evaluated. In vitro CA enzyme activity was determined colorimetrically using the CO₂ hydration method of Maren. IC�
• PMID 21635213

Japanese Journal

• 炭酸脱水酵素阻害薬 (特集 利尿薬およびそれに関連する話題)

• 小武海 公明
• 循環器内科 75(3), 274-276, 2014-03
• NAID 40020021022

• プロスタグランジン関連点眼液併用下でのβ遮断点眼液あるいは炭酸脱水酵素阻害点眼液から1%ドルソラミド塩酸塩・0.5%チモロールマレイン酸塩配合点眼液への変更時の眼圧下降効果と安全性

• 井上 賢治,富田 剛司
• あたらしい眼科 31(1), 115-118, 2014-01
• NAID 40019958111

• CLINICAL INVESTIGATION : Persistence with topical glaucoma therapy among newly diagnosed Japanese patients

• Kashiwagi Kenji,Furuya Toshie
• Japanese journal of ophthalmology : the official international journal of the Japanese Ophthalmological Society 58(1), 68-74, 2014-01
• NAID 40019946937

Related Links

• CA1 - Carbonic anhydrase 1 - Homo sapiens (Human) - CA1 ...

"Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII, and XIV with L- and D-phenylalanine and crystallographic analysis of their adducts with isozyme II: stereospecific recognition within the active site of an enzyme ...

• Carbonic Anhydrase - RCSB Protein Data Bank - RCSB PDB

Carbonic Anhydrase in Health and Disease Since this enzyme produces and uses protons and bicarbonate ions, carbonic anhydrase plays a key role in the regulation of pH and fluid balance in different parts of our body. In our ...

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★リンクテーブル★

関連記事	「I」「carbonic」「Id」「anhydrase」「carbon」

「I」

　　[★]

• イソロイシン isoleucine
• イノシン inosine
• 阻害剤 inhibitor
• iodine
• ヨード iodide
• I因子 factor I

　 　 　

「carbonic」

　　[★]

• 炭素の、炭酸の、カルボニック

関

C、carbon、carbonate、carbonic acid

「Id」

　　[★]

• イディオタイプ idiotype idiotypic
• inhibitor of DNA binding

「anhydrase」

　　[★]

アンヒドラーゼ、脱水酵素

関

dehydrase、dehydratase

「carbon」

　　[★]

炭素、カーボン

関

C、carbonic