WordNet

street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
having the characteristics of an acid; "an acid reaction"
resulting from or employing derivation; "a derivative process"; "a highly derivative prose style"
a compound obtained from, or regarded as derived from, another compound
(linguistics) a word that is derived from another word; "`electricity is a derivative of `electric"
an abundant nonmetallic tetravalent element occurring in three allotropic forms: amorphous carbon and graphite and diamond; occurs in all organic compounds (同)C, atomic number 6
a copy made with carbon paper (同)carbon_copy

PrepTutorEJDIC

酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD
派生した,由来した;独創性のない,借り物めいた / 派生語 / 派生した物
『炭素』(化学記号は『C』) / 〈C〉炭素棒 / 〈C〉《時に〈U〉》=carbon paper

UpToDate Contents

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1. 胎児の酸塩基の生理学 fetal acid base physiology
2. Chapter 11A：腎臓での水排泄 chapter 11a renal hydrogen excretion
3. 関節内および軟部組織注射：注射剤の種類および投与頻度 intraarticular and soft tissue injections what agents to inject and how frequently
4. 神経管欠損予防のための葉酸 folic acid for prevention of neural tube defects
5. 代謝性アルカローシスの治療 treatment of metabolic alkalosis

English Journal

Design, synthesis, and evaluation of hydroxamic acid derivatives as promising agents for the management of Chagas disease.

Rodrigues GC1, Feijó DF, Bozza MT, Pan P, Vullo D, Parkkila S, Supuran CT, Capasso C, Aguiar AP, Vermelho AB.Author information 1Laboratório de Síntese Orgânica, Departamento de Química, Instituto Militar de Engenharia, IME , Rio de Janeiro, Brasil.AbstractToday, there are approximately 8 million cases of Chagas disease in the southern cone of South America alone, and about 100 million people are living with the risk of becoming infected. The present pharmacotherapy is sometimes ineffective and has serious side effects. Here, we report a series of 4,5-dihydroisoxazoles incorporating hydroxamate moieties, which act as effective inhibitors of the carbonic anhydrase (CA) from Trypanosoma cruzi (TcCA). One compound (5g) was evaluated in detail and shows promising features as an antitrypanosomal agent. Excellent values for the inhibition of growth for all three developmental forms of the parasite were observed at low concentrations of 5g (IC50 values from 7.0 to <1 μM). The compound has a selectivity index (SI) of 6.7 and no cytotoxicity to macrophage cells. Preliminary in vivo data showed that 5g reduces bloodstream parasites and that all treated mice survived; it was also more effective than the standard drug benznidazole.
Journal of medicinal chemistry.J Med Chem.2014 Jan 23;57(2):298-308. doi: 10.1021/jm400902y. Epub 2013 Dec 13.
Today, there are approximately 8 million cases of Chagas disease in the southern cone of South America alone, and about 100 million people are living with the risk of becoming infected. The present pharmacotherapy is sometimes ineffective and has serious side effects. Here, we report a series of 4,5
PMID 24299463

Elevated carbon dioxide upregulates NBCn1 Na+/HCO3(-) cotransporter in human embryonic kidney cells.

Orlowski A1, Vargas LA, Aiello EA, Álvarez BV.Author information 1Centro de Investigaciones Cardiovasculares, Facultad de Ciencias Médicas, UNLP, Calle 60 y 120, 1900, La Plata, Argentina. balvarez@med.unlp.edu.ar.AbstractThe NBCn1 Na(+)/HCO3(-) cotransporter catalyzes the electroneutral movement of 1 Na(+):1 HCO3(-) into kidney cells. We characterized the intracellular pH (pHi) regulation in human embryonic kidney cells (HEK) subjected to NH4Cl prepulse acid loading, and we examined the NBCn1 expression and function in HEK cells subjected to 24-h elevated Pco2 (10-15%). After acid loading, in the presence of HCO3(-), ∼50% of the pHi recovery phase was blocked by the Na(+)/H(+) exchanger inhibitors EIPA (10-50 μM) and amiloride (1 mM) and was fully cancelled by 30 μM EIPA under nominally HCO3(-)-free conditions. In addition, in the presence of HCO3(-), pHi recovery after acid loading was completely blocked when Na(+) was omitted in the buffer. pHi recovery after acidification in HEK cells was repeated in the presence of the NBC inhibitor S0859, and the pHi recovery was inhibited by S0859 in a dose-dependent manner (Ki = 30 μM, full inhibition at 60 μM), which confirmed NBC Na(+)/HCO3(-) cotransporter activation. NBCn1 expression increased threefold after 24-h exposure of cultured HEK cells to 10% CO2 and sevenfold after exposure to 15% CO2, examined by immunoblots. Finally, exposure of HEK cells to high CO2 significantly increased the HCO3(-)-dependent recovery of pHi after acid loading. We conclude that HEK cells expressed the NBCn1 Na(+)/HCO3(-) cotransporter as the only HCO3(-)-dependent mechanism responsible for cellular alkaline loading. NBCn1, which expresses in different kidney cell types, was upregulated by 24-h high-Pco2 exposure of HEK cells, and this upregulation was accompanied by increased NBCn1-mediated HCO3(-) transport.
American journal of physiology. Renal physiology.Am J Physiol Renal Physiol.2013 Dec 15;305(12):F1765-74. doi: 10.1152/ajprenal.00096.2013. Epub 2013 Sep 4.
The NBCn1 Na(+)/HCO3(-) cotransporter catalyzes the electroneutral movement of 1 Na(+):1 HCO3(-) into kidney cells. We characterized the intracellular pH (pHi) regulation in human embryonic kidney cells (HEK) subjected to NH4Cl prepulse acid loading, and we examined the NBCn1 expression and function
PMID 24005470

Japanese Journal

含フッ化物アンモニウム塩混合アルカリ性浴によるアルミニウムの陽極酸化における炭酸誘導体・酸アミドの添加効果

野口駿雄,吉村長蔵
表面技術 43(2), 144-149, 1992
… fluoride.In this paper the effect of carbonic acid derivatives and acid amides on aluminum anodizing were investigated in ammonium carbonate (carbonate-fluoride) baths and ammonium borate (borate-fluoride) baths containing ammonium fluoride.During the anodizing of aluminum in baths containing carbonic acid derivatives or acid amides, bath voltage decreased and …
NAID 130001072959

二三のポリビニルアルコール誘導体のHg^2+,Cd^2+吸着能

松本昌一,マツモトマサカズ,Matsumoto Masakazu
山形大学紀要. 工学 17(2), 155-170, 1983-01-20
… From (1) and (2) polyvinyl alcohol derivatives containing SH group are obtained. … (3) Aminoacetals of polyvinyl alcohol synthesized by the reaction between polyvinyl alcohol and aminoacetals are treated with monochloroacetic acid. … (4) polyvinyl alcohol is acetalized by aminoacetal containing carbonic acid group. …
NAID 110004875657