WordNet
- a salt of phosphoric acid (同)orthophosphate, inorganic_phosphate
- carbonated drink with fruit syrup and a little phosphoric acid
PrepTutorEJDIC
- 〈U〉リン酸塩 / 《複数形で》リン酸肥料
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/11/23 11:59:09」(JST)
[Wiki en表示]
Carbamoyl phosphate |
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IUPAC name
(Carbamoyloxy)phosphonic acid
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Identifiers |
CAS number |
590-55-6 Y |
PubChem |
278 |
ChemSpider |
272 N |
KEGG |
C00169 N |
MeSH |
Carbamoyl+phosphate |
ChEBI |
CHEBI:17672 N |
ChEMBL |
CHEMBL369105 N |
Jmol-3D images |
Image 1 |
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InChI=1S/CH4NO5P/c2-1(3)7-8(4,5)6/h(H2,2,3)(H2,4,5,6)
Key: FFQKYPRQEYGKAF-UHFFFAOYSA-N
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Properties |
Molecular formula |
CH2NO5P2− |
Molar mass |
141.020 g/mol |
N (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
Infobox references |
Carbamoyl phosphate is an anion of biochemical significance. In land-dwelling animals it is an intermediary metabolite participating in the nitrogen disposal through in the urea cycle and the synthesis of pyrimidines.
Production[edit]
It is produced from bicarbonate, ammonia (derived from glutamine), and phosphate (from ATP). The synthesis is catalysed by the enzyme carbamoyl phosphate synthetase, as follows:
- HCO3− + ATP → ADP + HO–C(O)–OPO32− (carboxyl phosphate)
- HO–C(O)–OPO32− + NH3 + OH− → HPO42− + −O–C(O)NH2 + H2O
- −O–C(O)NH2 + ATP → ADP + H2NC(O)OPO32−
See also[edit]
- Ornithine transcarbamylase
References[edit]
- Nelson, David L. and Michael M. Cox. Lehninger Principles of Biochemistry fourth edition. W. H. Freeman and company New York.
Nucleotide metabolic intermediates
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Purine metabolism |
Anabolism
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R5P→IMP: R5P · PRPP · PRA · GAR · FGAR · FGAM · AIR · CAIR · SAICAR · AICAR · FAICAR
IMP→AMP: Adenylosuccinate
IMP→GMP: Xanthosine monophosphate
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Catabolism
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Hypoxanthine · Xanthine · Uric acid · 5-Hydroxyisourate
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Pyrimidine metabolism |
Anabolism
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Carbamoyl phosphate · Carbamoyl aspartic acid · 4,5-Dihydroorotic acid · Orotic acid · Orotidine 5'-monophosphate · Uridine monophosphate
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Catabolism
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uracil: Dihydrouracil · 3-Ureidopropionic acid · β-Alanine
thymine: Dihydrothymine · β-Ureidoisobutyric acid · 3-Aminoisobutyric acid
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mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m
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k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon
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m (A16/C10), i (k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)
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- Biochemical families: carbohydrates
- alcohols
- glycoproteins
- glycosides
- lipids
- eicosanoids
- fatty acids / intermediates
- phospholipids
- sphingolipids
- steroids
- nucleic acids
- constituents / intermediates
- proteins
- Amino acids / intermediates
- tetrapyrroles / intermediates
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Urea cycle Metabolic Pathway |
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L-citrulline |
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Carbamoyl
phosphate |
L-ornithine |
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Pi |
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L-aspartate |
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Urea |
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+ |
ATP |
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PPi |
+ |
AMP |
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H2O |
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L-argininosuccinate |
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Fumarate |
L-arginine |
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mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m
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k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon
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m (A16/C10), i (k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)
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UpToDate Contents
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English Journal
- Glutaminase 1 inhibition reduces thymidine synthesis in NSCLC.
- Lee JS1, Kang JH1, Lee SH1, Lee CH1, Son J2, Kim SY3.
- Biochemical and biophysical research communications.Biochem Biophys Res Commun.2016 Aug 26;477(3):374-82. doi: 10.1016/j.bbrc.2016.06.095. Epub 2016 Jun 23.
- We found that non-small cell lung cancer (NSCLC) is remarkably sensitive to the regulation of glutamine supply by testing the metabolic dependency of 11 cancer cell lines against regulation of glycolysis, autophagy, fatty acid synthesis, and glutamine supply. Glutamine is known as a key supplement o
- PMID 27338638
- DIFFERENTIAL PROTEOME ANALYSIS OF THE MALE AND FEMALE ANTENNAE FROM Holotrichia parallela.
- Zhang JH1, Wang S1, Yang S1, Yi J1, Liu Y1, Xi JH1.
- Archives of insect biochemistry and physiology.Arch Insect Biochem Physiol.2016 Aug;92(4):274-87. doi: 10.1002/arch.21338. Epub 2016 Jul 11.
- To understand the olfactory mechanisms of Holotrichia parallela antennae in detecting volatile compounds in the environment, protein profiles of H. parallela antennae were analyzed using two-dimensional electrophoresis followed by mass spectrometry and bioinformatics analyses. Approximately 1,100 pr
- PMID 27396371
- Inhibitors of alanine racemase enzyme: a review.
- Azam MA1, Jayaram U1.
- Journal of enzyme inhibition and medicinal chemistry.J Enzyme Inhib Med Chem.2016 Aug;31(4):517-26. doi: 10.3109/14756366.2015.1050010. Epub 2015 May 29.
- Alanine racemase is a fold type III PLP-dependent amino acid racemase enzyme catalysing the conversion of l-alanine to d-alanine utilised by bacterial cell wall for peptidoglycan synthesis. As there are no known homologs in humans, it is considered as an excellent antibacterial drug target. The stan
- PMID 26024289
Japanese Journal
- Elimination and active extrusion of liver mitochondrial proteins during lipopolysaccharide administration in rat
- UNUMA Kana,AKI Toshihiko,MATSUDA Seiji,FUNAKOSHI Takeshi,YOSHIDA Ken-ichi,UEMURA Koichi
- Hepatology research : the official journal of the Japan Society of Hepatology 43(5), 526-534, 2013-05-01
- NAID 10031183486
- Little gene flow between domestic silkmoth Bombyx mori and its wild relative Bombyx mandarina in Japan, and possible artificial selection on the CAD gene of B. mori
- Yukuhiro Kenji,Sezutsu Hideki,Tamura Toshiki [他],Kosegawa Eiichi,Iwata Kazuya,Ajimura Masahiro,Gu Shi-Hong,Wang Min,Xia Qingyou,Mita Kazuei,Kiuchi Makoto
- Genes & Genetic Systems 87(5), 331-340, 2012
- … We analyzed PCR-amplified carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD) gene fragments from 146 Bombyx mori native strains and found extremely low levels of DNA polymorphism. …
- NAID 130003360984
Related Links
- Wikipedia(ウィキペディア)記事検索 > [ Carbamoyl phosphate synthetase ] の検索結果
- car·ba·mo·yl phos·phate (kar'bă-mō-il fos'fāt), A reactive intermediate capable of transferring its carbamoyl group to an acceptor molecule, forming citrulline from ornithine in the urea cycle and ureidosuccinate from aspartate in ...
★リンクテーブル★
[★]
- 英
- carbamoyl phosphate
H2N-CO-(OPO3)2-
- オルニチン回路に入る物質である。窒素、重炭酸イオン、およびATPから生成される。この反応はミトコンドリアで起こる。
[★]
カルバミルリン酸
- 関
- carbamoyl phosphate
[★]
カルバモイルリン酸合成酵素、カルバモイルリン酸シンターゼ
- 関
- carbamoyl-phosphate synthetase、carbamoyl-phosphate synthetase I
[★]
グルタミン加水分解性カルバモイルリン酸合成酵素、グルタミン加水分解性カルバモイルリン酸シンターゼ
[★]
カルバモイルリン酸合成酵素I、カルバモイルリン酸シンターゼI
- 関
- carbamoyl-phosphate synthetase I
[★]
- 英
- カルバモイルリン酸合成酵素
[★]
カルバモイルリン酸合成酵素
[★]
- 関
- inorganic phosphate、orthophosphate、orthophosphoric acid、phospho、phosphoester、phosphoric、phosphoric acid、phosphoric acid ester、phosphorus