glutamine-hydrolyzing carbamoyl-phosphate synthase

グルタミン加水分解性カルバモイルリン酸合成酵素、グルタミン加水分解性カルバモイルリン酸シンターゼ

WordNet

1. a salt of phosphoric acid (同)orthophosphate, inorganic_phosphate
2. carbonated drink with fruit syrup and a little phosphoric acid
3. a crystalline amino acid occurring in proteins; important in protein metabolism

PrepTutorEJDIC

1. 〈U〉リン酸塩 / 《複数形で》リン酸肥料

UpToDate Contents

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• 1. 尿素サイクル障害：管理 urea cycle disorders management
• 2. Chapter 3B：近位尿細管におけるナトリウム輸送能の優越性 chapter 3b primacy of sodium transport in proximal function
• 3. 化学療法に関連した経口毒性 oral toxicity associated with chemotherapy
• 4. 癌患者における経口栄養補給および経口／経腸栄養補給の役割 the role of parenteral and enteral oral nutritional support in patients with cancer
• 5. 重症患者における栄養補給：非経口的栄養 nutrition support in critically ill patients parenteral nutrition

English Journal

• Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis.

• Rabinovich S1, Adler L1, Yizhak K2, Sarver A1, Silberman A1, Agron S1, Stettner N1, Sun Q3, Brandis A4, Helbling D5, Korman S6, Itzkovitz S7, Dimmock D5, Ulitsky I1, Nagamani SC3,8, Ruppin E2,9,10, Erez A1.
• Nature.Nature.2015 Nov 19;527(7578):379-83. doi: 10.1038/nature15529. Epub 2015 Nov 11.
• Cancer cells hijack and remodel existing metabolic pathways for their benefit. Argininosuccinate synthase (ASS1) is a urea cycle enzyme that is essential in the conversion of nitrogen from ammonia and aspartate to urea. A decrease in nitrogen flux through ASS1 in the liver causes the urea cycle diso
• PMID 26560030

• Biallelic mutations in CAD, impair de novo pyrimidine biosynthesis and decrease glycosylation precursors.

• Ng BG1, Wolfe LA2, Ichikawa M1, Markello T2, He M3, Tifft CJ4, Gahl WA4, Freeze HH5.
• Human molecular genetics.Hum Mol Genet.2015 Jun 1;24(11):3050-7. doi: 10.1093/hmg/ddv057. Epub 2015 Feb 12.
• In mitochondria, carbamoyl-phosphate synthetase 1 activity produces carbamoyl phosphate for urea synthesis, and deficiency results in hyperammonemia. Cytoplasmic carbamoyl-phosphate synthetase 2, however, is part of a tri-functional enzyme encoded by CAD; no human disease has been attributed to this
• PMID 25678555

• Rheb protein binds CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, and dihydroorotase) protein in a GTP- and effector domain-dependent manner and influences its cellular localization and carbamoyl-phosphate synthetase (CPSase) activity.

• Sato T1, Akasu H2, Shimono W2, Matsu C2, Fujiwara Y2, Shibagaki Y2, Heard JJ3, Tamanoi F3, Hattori S2.
• The Journal of biological chemistry.J Biol Chem.2015 Jan 9;290(2):1096-105. doi: 10.1074/jbc.M114.592402. Epub 2014 Nov 24.
• Rheb small GTPases, which consist of Rheb1 and Rheb2 (also known as RhebL1) in mammalian cells, are unique members of the Ras superfamily and play central roles in regulating protein synthesis and cell growth by activating mTOR. To gain further insight into the function of Rheb, we carried out a sea
• PMID 25422319

Japanese Journal

• Start site selection at the TATA-less carbamoyl-phosphate synthase (glutamine-hydrolyzing)/aspartate carbamoyltransferase/dihydroorotase promoter

• KOLLMAR R
• J Biol Chem 269, 2252-2257, 1994
• NAID 80007455750

Related Links

• ENZYME entry 6.3.5.5

Carbamoyl-phosphate synthase (glutamine-hydrolyzing).

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★リンクテーブル★

リンク元	「グルタミン加水分解性カルバモイルリン酸合成酵素」「グルタミン加水分解性カルバモイルリン酸シンターゼ」
関連記事	「phosphate」「synthase」「glutamine」

「グルタミン加水分解性カルバモイルリン酸合成酵素」

　　[★]

英

glutamine-hydrolyzing carbamoyl-phosphate synthase

関

グルタミン加水分解性カルバモイルリン酸シンターゼ

「グルタミン加水分解性カルバモイルリン酸シンターゼ」

　　[★]

英

glutamine-hydrolyzing carbamoyl-phosphate synthase

関

グルタミン加水分解性カルバモイルリン酸合成酵素

「phosphate」

　　[★]

• n.

• (化合物)リン酸塩、リン酸エステル、ホスフェート、フォスフェート、リン酸

関

inorganic phosphate、orthophosphate、orthophosphoric acid、phospho、phosphoester、phosphoric、phosphoric acid、phosphoric acid ester、phosphorus

　 　 　

「synthase」

　　[★]

• n.

• (脱離酵素リアーゼの逆反応である合成方向の反応を指す) シンターゼ, 合成酵素, 付加酵素

関

lyase、synthetase、transferase

「glutamine」

　　[★] グルタミン Gln Q, L-glutamine