カルバミルリン酸
- 関
- carbamoyl phosphate
WordNet
- a salt of phosphoric acid (同)orthophosphate, inorganic_phosphate
- carbonated drink with fruit syrup and a little phosphoric acid
PrepTutorEJDIC
- 〈U〉リン酸塩 / 《複数形で》リン酸肥料
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/08 21:26:35」(JST)
[Wiki en表示]
Carbamoyl phosphate
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| Names |
| IUPAC name
(Carbamoyloxy)phosphonic acid
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| Identifiers |
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CAS Registry Number
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590-55-6 Y |
| ChEBI |
CHEBI:17672 N |
| ChEMBL |
ChEMBL369105 N |
| ChemSpider |
272 N |
InChI
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InChI=1S/CH4NO5P/c2-1(3)7-8(4,5)6/h(H2,2,3)(H2,4,5,6)
Key: FFQKYPRQEYGKAF-UHFFFAOYSA-N
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| Jmol-3D images |
Image |
| KEGG |
C00169 N |
| MeSH |
Carbamoyl+phosphate |
| PubChem |
278 |
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| Properties |
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Chemical formula
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CH2NO5P2− |
| Molar mass |
141.020 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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| N verify (what is: Y/N?) |
| Infobox references |
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Carbamoyl phosphate is an anion of biochemical significance. In land-dwelling animals, it is an intermediary metabolite in nitrogen disposal through the urea cycle and the synthesis of pyrimidines.
Production
It is produced from bicarbonate, ammonia (derived from glutamine), and phosphate (from ATP). The synthesis is catalysed by the enzyme carbamoyl phosphate synthetase, as follows:
- HCO3− + ATP → ADP + HO–C(O)–OPO32− (carboxyl phosphate)
- HO–C(O)–OPO32− + NH3 + OH− → HPO42− + −O–C(O)NH2 + H2O
- −O–C(O)NH2 + ATP → ADP + H2NC(O)OPO32−
See also
- Ornithine transcarbamylase
References
- Nelson, David L. and Michael M. Cox. Lehninger Principles of Biochemistry fourth edition. W. H. Freeman and company New York.
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Nucleotide metabolic intermediates
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| Purine metabolism |
| Anabolism |
| R5P→IMP: |
- R5P
- PRPP
- PRA
- GAR
- FGAR
- FGAM
- AIR
- CAIR
- SAICAR
- AICAR
- FAICAR
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| IMP→AMP: |
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| IMP→GMP: |
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| Catabolism |
- Hypoxanthine
- Xanthine
- Uric acid
- 5-Hydroxyisourate
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| Pyrimidine metabolism |
| Anabolism |
- Carbamoyl phosphate
- Carbamoyl aspartic acid
- 4,5-Dihydroorotic acid
- Orotic acid
- Orotidine 5'-monophosphate
- Uridine monophosphate
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| Catabolism |
| uracil: |
- Dihydrouracil
- 3-Ureidopropionic acid
- β-Alanine
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| thymine: |
- Dihydrothymine
- β-Ureidoisobutyric acid
- 3-Aminoisobutyric acid
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Index of inborn errors of metabolism
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| Description |
- Metabolism
- Enzymes and pathways: citric acid cycle
- pentose phosphate
- glycoproteins
- glycosaminoglycans
- phospholipid
- cholesterol and steroid
- sphingolipids
- eicosanoids
- amino acid
- urea cycle
- nucleotide
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| Disorders |
- Citric acid cycle and electron transport chain
- Glycoprotein
- Proteoglycan
- Fatty-acid
- Phospholipid
- Cholesterol and steroid
- Eicosanoid
- Amino acid
- Purine-pyrimidine
- Heme metabolism
- Symptoms and signs
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| Treatment |
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Index of biochemical families
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| Carbohydrates |
- Alcohols
- Glycoproteins
- Glycosides
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| Lipids |
- Eicosanoids
- Fatty acids
- Glycerides
- Phospholipids
- Sphingolipids
- Steroids
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| Nucleic acids |
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| Proteins |
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| Other |
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Urea cycle Metabolic Pathway |
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L-citrulline |
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Carbamoyl
phosphate |
L-ornithine |
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Pi |
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| L-aspartate |
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Urea |
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+ |
ATP |
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| PPi |
+ |
AMP |
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H2O |
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L-argininosuccinate |
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Fumarate |
L-arginine |
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Index of inborn errors of metabolism
|
|
| Description |
- Metabolism
- Enzymes and pathways: citric acid cycle
- pentose phosphate
- glycoproteins
- glycosaminoglycans
- phospholipid
- cholesterol and steroid
- sphingolipids
- eicosanoids
- amino acid
- urea cycle
- nucleotide
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| Disorders |
- Citric acid cycle and electron transport chain
- Glycoprotein
- Proteoglycan
- Fatty-acid
- Phospholipid
- Cholesterol and steroid
- Eicosanoid
- Amino acid
- Purine-pyrimidine
- Heme metabolism
- Symptoms and signs
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| Treatment |
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UpToDate Contents
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English Journal
- Augmenting ureagenesis in patients with partial carbamyl phosphate synthetase 1 deficiency with N-carbamyl-L-glutamate.
- Ah Mew N1, McCarter R2, Daikhin Y3, Lichter-Konecki U1, Nissim I3, Yudkoff M3, Tuchman M4.
- The Journal of pediatrics.J Pediatr.2014 Aug;165(2):401-403.e3. doi: 10.1016/j.jpeds.2014.04.012. Epub 2014 May 29.
- Identical studies using stable isotopes were performed before and after a 3-day trial of oral N-carbamyl-l-glutamate (NCG) in 5 subjects with late-onset carbamyl phosphate synthetase deficiency. NCG augmented ureagenesis and decreased plasma ammonia in 4 of 5 subjects. There was marked improvement i
- PMID 24880889
- Cold storage of liver microorgans in ViaSpan and BG35 solutions: study of ammonia metabolism during normothermic reoxygenation.
- Pizarro MD1, Mediavilla MG1, Berardi F1, Tiribelli C2, Rodríguez JV1, Mamprin ME3.
- Annals of hepatology.Ann Hepatol.2014 Mar-Apr;13(2):256-64.
- INTRODUCTION: This work focuses on ammonia metabolism of Liver Microorgans (LMOs) after cold preservation in a normothermic reoxygenation system (NRS). We have previously reported the development of a novel preservation solution, Bes-Gluconate-PEG 35 kDa (BG35) that showed the same efficacy as ViaSp
- PMID 24552868
- Coordinating role of His216 in MgATP binding and cleavage in pyruvate carboxylase.
- Adina-Zada A1, Jitrapakdee S, Wallace JC, Attwood PV.
- Biochemistry.Biochemistry.2014 Feb 18;53(6):1051-8. doi: 10.1021/bi4016814. Epub 2014 Feb 5.
- His216 is a well-conserved residue in pyruvate carboxylases and, on the basis of structures of the enzyme, appears to have a role in the binding of MgATP, forming an interaction with the 3'-hydroxyl group of the ribose ring. Mutation of this residue to asparagine results in a 9-fold increase in the
- PMID 24460480
Japanese Journal
- Characterization of genomic structure and polymorphisms in the human carbamyl phosphate synthetase I gene
- Immunohistochemical Localization of Pyruvate Carboxylase and Carbamyl-Phosphate Synthetase I in Normal and Neoplastic Human Pancreatic Tissues
- SATO Tetsuro,KASHIMA Kenji,GAMACHI Ayako,DAA Tsutomu,NAKAYAMA Iwao,YOKOYAMA Shigeo
- Pancreas 25(2), 130-135, 2002-08-01
- NAID 10013987285
- OME2000-82 バイエンザイムリアクターを用いたオルニチン計測
- 大熊 廣一,佐藤 稔英
- 電子情報通信学会技術研究報告. OME, 有機エレクトロニクス 100(252), 137-141, 2000-08-14
- エビ類の鮮度判定に有用な、オルニチン量を簡便・迅速に計測するバイエンザイムリアクター型センサシステムの開発を行った。本センサシステムは、オルニチンカルバミルトランスフェラーゼ(OCT)とピルビン酸オキシダーゼ(POPG)をガラスビーズに固定化して酸素電極と組合せて構成した。これにカルバミルリン酸とピルビン酸を共存させた緩衝液を通液し、オルニチンをOCTでシトルリンとリン酸イオンに分解し、このリン酸 …
- NAID 110003301218
Related Links
- ・Carbamyl-Phosphate Synthase (Ammonia) ・carbamyl-phosphate synthetase I ・CP Synthase I ・カルバモイルリン酸シンターゼ ・カルバモイルリン酸シンターゼI ・カルバモイルリン酸シンテターゼ ・カルバモイルリン酸シンテターゼI ...
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★リンクテーブル★
[★]
- 英
- carbamyl phosphate
- 関
- カルバモイルリン酸
[★]
カルバモイルリン酸合成酵素欠損症
[★]
カルバモイルリン酸合成酵素
[★]
- 関
- inorganic phosphate、orthophosphate、orthophosphoric acid、phospho、phosphoester、phosphoric、phosphoric acid、phosphoric acid ester、phosphorus