WordNet
- a white metallic element that burns with a brilliant light; the fifth most abundant element in the earths crust; an important component of most plants and animals (同)Ca, atomic number 20
- a salt or ester of pyrophosphoric acid
PrepTutorEJDIC
- 『カルシウム』(金属元素;化学記号は『Ca』)
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- 1. ピロリン酸カルシウム結晶沈着症の臨床症状および診断 clinical manifestations and diagnosis of calcium pyrophosphate crystal deposition disease
- 2. ピロリン酸カルシウム結晶沈着症の治療 treatment of calcium pyrophosphate crystal deposition disease
- 3. Regulation of calcium and phosphate balance
- 4. ピロリン酸カルシウム結晶沈着症の発症および病因 pathogenesis and etiology of calcium pyrophosphate crystal deposition disease
- 5. 変形性関節症の診断および分類 diagnosis and classification of osteoarthritis
English Journal
- Imaging characteristics of calcium pyrophosphate dihydrate crystal deposition disease.
- Lin YY1, Wang TG, Li KJ, Lew HL.
- American journal of physical medicine & rehabilitation / Association of Academic Physiatrists.Am J Phys Med Rehabil.2014 Mar;93(3):272-3. doi: 10.1097/PHM.0b013e31825566aa.
- PMID 22561381
- miRNA-221 and miRNA-222 synergistically function to promote vascular calcification.
- Mackenzie NC1, Staines KA, Zhu D, Genever P, Macrae VE.Author information 1Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK.AbstractVascular calcification shares many similarities with skeletal mineralisation and involves the phenotypic trans-differentiation of vascular smooth muscle cells (VSMCs) to osteoblastic cells within a calcified environment. Various microRNAs (miRs) are known to regulate cell differentiation; however, their role in mediating VSMC calcification is not fully understood. miR-microarray analysis revealed the significant down-regulation of a range of miRs following nine days in culture, including miR-199b, miR-29a, miR-221, miR-222 and miR-31 (p < 0.05). Subsequent studies investigated the specific role of the miR-221/222 family in VSMC calcification. Real-time quantitative polymerase chain reaction data confirmed the down-regulation of miR-221 (32.4%; p < 0.01) and miR-222 (15.7%; p < 0.05). VSMCs were transfected with mimics of miR-221 and miR-222, individually and in combination. Increased calcium deposition was observed in the combined treatment (two-fold; p < 0.05) but not in individual treatments. Runx2 and Msx2 expression was increased during calcification, but no difference in expression was observed following transfection with miR mimics. Interestingly, miR-221 and miR-222 mimics induced significant changes in ectonucleotide phosphodiesterase 1 (Enpp1) and Pit-1 expression, suggesting that these miRs may modulate VSMC calcification through cellular inorganic phosphate and pyrophosphate levels. © 2013 The Authors. Cell Biochemistry and Function published by John Wiley & Sons, Ltd.
- Cell biochemistry and function.Cell Biochem Funct.2014 Mar;32(2):209-16. doi: 10.1002/cbf.3005. Epub 2013 Oct 8.
- Vascular calcification shares many similarities with skeletal mineralisation and involves the phenotypic trans-differentiation of vascular smooth muscle cells (VSMCs) to osteoblastic cells within a calcified environment. Various microRNAs (miRs) are known to regulate cell differentiation; however, t
- PMID 24604335
Japanese Journal
- 急性炎症により頚椎症性脊髄症の急性増悪を来した黄色靭帯 CPPD (Calcium pyrophosphate dihydrate) 沈着症の2例
- 薗 隆,村田 壮平,岡畠 章憲,中村 智,松下 睦
- 中部日本整形外科災害外科学会雑誌. 中部日本整形外科災害外科学会抄録 54(6), 1145-1146, 2011-11-01
- NAID 10030185197
- 偽痛風〔ピロリン酸カルシウム(CPPD)結晶沈着症〕
- 益田 郁子
- 内分泌・糖尿病・代謝内科 33(5), 485-492, 2011-11
- NAID 40019154849
Related Links
- Calcium Pyrophosphate Deposition Disease. Calcium pyrophosphate deposition disease (CPDD) is a metabolic arthropathy caused by the deposition of calcium pyrophosphate dihydrate in and around joints, especially in ...
- Calcium pyrophosphate dihydrate disease (CPPD disease) is common, especially in the elderly, and is characterised by the deposition of calcium pyrophosphate in soft tissues and cartilage.CPPD is one of many causes of soft ...
Related Pictures
★リンクテーブル★
「偽痛風」
概念
- ピロリン酸カルシウム2水和物(calcium pyrophosphate dihydrate, CPPD, Ca2P2O7・2H2O)の関節内への沈着による急性関節炎
- X線所見から軟骨石灰化症と呼ばれる
疫学
- 高齢者に多い。
- 80歳以上の半数に認められる
- 65歳以上の高齢の女性女性に多い(REU.301)
- 加齢により軟骨石灰化の頻度は上昇し、65-75歳では10-15%、85歳以上では30-60%にみられる。症状を呈するのはその一部である。(REU.301)
病因
- ポケメ
- (大部分)特発性
- 代謝性：ヘモクロマトーシス、甲状腺機能低下症、甲状腺機能亢進症、糖尿病、低マグネシウム血症、ALP欠乏、家族性脂質異常症、痛風、ギテルマン症候群、X連鎖性低リン酸血性くる病
- 関節外傷：
- 家族性軟骨石灰化症
好発部位
- 膝関節が最多。手関節の線維性軟骨、恥骨結合、関節唇、椎間板線維輪
症候
- 頻度：膝関節(約半数) > 足関節
- 関節
- 急性関節炎
- 関節液：白濁(白血球の増多による)
- 変形性関節症：多くの症例で合併が認められる。
- (ときに)全身症状：発熱、白血球増多、CRP上昇、赤沈亢進
経過
- 関節炎：数時間～1日でピーク。数日～2週間持続して軽快
検査
- 血液検査：白血球増多、CRP上昇、赤沈亢進が認められることがある。
- 単純X線写真：点状、線状の軟骨石灰化
- 半月板の石灰化
- 関節穿刺： ← 確定診断
- ピロリン酸カルシウム2水和物の結晶。偏光顕微鏡下で弱い正の複屈折性が認められる
- 小さい結晶は白血球に貪食されている。
国試
「ピロリン酸カルシウム」
# 索引 -CPPD REU 301
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- Ca2P2O7
「CPPD」
[★] ピロリン酸カルシウム。ピロリン酸カルシウム二水和物 calcium pyrophosphate dihydrate
「ピロリン酸カルシウム二水和物」
「calcium pyrophosphate」
「calcium pyrophosphate dihydrate deposition」
「calcium pyrophosphate dihydrate deposition disease」
「pyrophosphate」
「calcium pyrophosphate」
「calcium」